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Abstract:

Responses to adrenoceptor agonistic drugs were examined in two regions of vasa deferentia (epididymal and prostetic) from adult intact and castrated rats. In the prostatic portion the stimulating alpha adrenergic responses following castration were greater than in the intact rats. On the other hand in the epididymal region the reactivity was smaller in preparations from castrated animals. A beta-adrenoceptor-inhibitory-mediated mechanism was only present in the epididymal segment of the castrated group; in which a clear spontaneous activity was observed. Testosterone treatment reversed the alpha and beta adrenergic effects detected after castration. Results show a relationship between testosterone and the spontaneous motility as well as an influence in the action of alpha and beta adrenergic agonists on their receptors. © 1981 The Italian Pharmacological Society.

Registro:

Documento: Artículo
Título:Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens
Autor:Borda, E.; Agostini, M.d.C.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). V. d, 1428 Buenos Aires, Argentina
Palabras clave:acetylsalicylic acid; alpha adrenergic receptor; atropine; beta adrenergic receptor; butoxamine; clonidine; noradrenalin; oxidopamine; phentolamine; phenylephrine; soterenol; testosterone; testosterone propionate; yohimbine; animal experiment; castration; endocrine system; male genital system; rat; smooth muscle contractility; vas deferens; Animal; Castration; Clonidine; Ethanolamines; In Vitro; Male; Muscle Contraction; Norepinephrine; Phenylephrine; Rats; Rats, Inbred Strains; Sympathomimetics; Testosterone; Vas Deferens
Año:1981
Volumen:13
Número:10
Página de inicio:981
Página de fin:996
DOI: http://dx.doi.org/10.1016/S0031-6989(81)80069-0
Título revista:Pharmacological Research Communications
Título revista abreviado:Pharmacol. Res. Commun.
ISSN:00316989
CODEN:PLRCA
CAS:acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; atropine, 51-55-8, 55-48-1; butoxamine, 1937-89-9; clonidine, 4205-90-7, 4205-91-8, 57066-25-8; noradrenalin, 1407-84-7, 51-41-2; oxidopamine, 1199-18-4, 28094-15-7, 636-00-0; phentolamine, 50-60-2, 73-05-2; phenylephrine, 532-38-7, 59-42-7, 61-76-7; soterenol, 13642-52-9, 14816-67-2; testosterone propionate, 57-85-2; testosterone, 58-22-0; yohimbine, 146-48-5, 65-19-0; Clonidine, 4205-90-7; Ethanolamines; Norepinephrine, 51-41-2; Phenylephrine, 59-42-7; soterenol, 13642-52-9; Sympathomimetics; Testosterone, 57-85-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n10_p981_Borda

Referencias:

  • Anton, Duncan, Mc Grath, (1977) J.Physiol., 273, p. 23
  • Borda, Agostini, Gimeno, Gimeno, (1981) Pharm.Res.Commun., 13, p. 487
  • Ganguly, Bhattacharya, (1970) Arch.int.Pharmacodyn, 185, p. 406
  • Greenberg, Kadowitz, Schedl, Long, (1973) J.Pharmacol.Exp.Ther., 85, p. 505
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  • Mc Donald, Mc Grath, THE EFFECTS OF CASTRATION ON NEUROTRANSMISSION IN THE RAT VAS DEFERENS (1980) British Journal of Pharmacology, 69, p. 49
  • Urquilla, Westfall, Goto, Fleming, (1978) J. Pharmacol.Exp.Ther., 207, p. 347
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Citas:

---------- APA ----------
Borda, E., Agostini, M.d.C., Gimeno, M.F. & Gimeno, A.L. (1981) . Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens. Pharmacological Research Communications, 13(10), 981-996.
http://dx.doi.org/10.1016/S0031-6989(81)80069-0
---------- CHICAGO ----------
Borda, E., Agostini, M.d.C., Gimeno, M.F., Gimeno, A.L. "Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens" . Pharmacological Research Communications 13, no. 10 (1981) : 981-996.
http://dx.doi.org/10.1016/S0031-6989(81)80069-0
---------- MLA ----------
Borda, E., Agostini, M.d.C., Gimeno, M.F., Gimeno, A.L. "Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens" . Pharmacological Research Communications, vol. 13, no. 10, 1981, pp. 981-996.
http://dx.doi.org/10.1016/S0031-6989(81)80069-0
---------- VANCOUVER ----------
Borda, E., Agostini, M.d.C., Gimeno, M.F., Gimeno, A.L. Castration alters the stimulatory and inhibitory adrenergic influences on isolated rat vas deferens. Pharmacol. Res. Commun. 1981;13(10):981-996.
http://dx.doi.org/10.1016/S0031-6989(81)80069-0