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Izquierdo, J.A.; Savini, C.; Borghi, E.; Rabiller, G.; Costas, S.; Justel, E. "Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin" (1978) Pharmacological Research Communications. 10(7):643-656
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Abstract:

Pregnenolone, medroxyprogesterone (MPA) and melengestrol (MLA) caused a significant decrease of brain stem serotonin (5-HT) in the adult female rat, without modifying the content of 5-hydroxy indoleacetic acid (5-HIAA). Only MPA and MLA increased the liver tryptophan pyrrolase (LTP) activity. Chlormadinone, in spite of its similar chemical structure, had no effect. Both total and free plasma tryptophan were not modified, except the latter which decreased when MPA was injected. The steroids herein studied had no effect on brain stem tryptophan and monoamino oxidase (MAO) system activity. The effect of MPA on 5-HT was antagonized in fasting, adrenalectomized and normal rats injected with ACTH. These results suggest that ACTH would participate in the effect of MPA on brain stem 5-HT. © 1978 The Italian Pharmacological Society.

Registro:

Documento: Artículo
Título:Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin
Autor:Izquierdo, J.A.; Savini, C.; Borghi, E.; Rabiller, G.; Costas, S.; Justel, E.
Filiación:Centro de Estudios Farmacológicos y de Frincipios Naturales, Consejo Nacional de Investigaciones Cientificas y Técnicas. Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:16alpha methylpregnenolone; chlormadinone; corticotropin; deoxycorticosterone; enzyme; hydroxyprogesterone; medroxyprogesterone; medroxyprogesterone acetate; melengestrol acetate; pregnenolone; progesterone acetate; serotonin; tetracosactide; tryptophan 2,3 dioxygenase; unclassified drug; animal experiment; article; brain stem; central nervous system; drug antagonism; drug comparison; endocrine system; rat; subcutaneous drug administration; Animals, Laboratory; Biology; Clinical Research; Contraception; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Family Planning; Hormones; Laboratory Procedures; Literature Review; Medroxyprogesterone Acetate--pharmacodynamics; Melengestrol Acetate--pharmacodynamics; Physiology; Research Methodology; Serotonin; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Brain Stem; Fasting; Female; Hydroxyindoleacetic Acid; Medroxyprogesterone; Monoamine Oxidase; Rats; Serotonin; Tryptophan
Año:1978
Volumen:10
Número:7
Página de inicio:643
Página de fin:656
DOI: http://dx.doi.org/10.1016/S0031-6989(78)80008-3
Título revista:Pharmacological Research Communications
Título revista abreviado:Pharmacol. Res. Commun.
ISSN:00316989
CODEN:PLRCA
CAS:chlormadinone, 1961-77-9; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; deoxycorticosterone, 64-85-7; hydroxyprogesterone, 68-96-2; medroxyprogesterone, 520-85-4; medroxyprogesterone acetate, 71-58-9; melengestrol acetate, 2919-66-6; pregnenolone, 145-13-1; serotonin, 50-67-9; tetracosactide, 16960-16-0; tryptophan 2,3 dioxygenase, 9014-51-1; Adrenocorticotropic Hormone, 9002-60-2; Hydroxyindoleacetic Acid, 54-16-0; Medroxyprogesterone, 520-85-4; Monoamine Oxidase, 1.4.3.4; Serotonin, 50-67-9; Tryptophan, 73-22-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v10_n7_p643_Izquierdo

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Citas:

---------- APA ----------
Izquierdo, J.A., Savini, C., Borghi, E., Rabiller, G., Costas, S. & Justel, E. (1978) . Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin. Pharmacological Research Communications, 10(7), 643-656.
http://dx.doi.org/10.1016/S0031-6989(78)80008-3
---------- CHICAGO ----------
Izquierdo, J.A., Savini, C., Borghi, E., Rabiller, G., Costas, S., Justel, E. "Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin" . Pharmacological Research Communications 10, no. 7 (1978) : 643-656.
http://dx.doi.org/10.1016/S0031-6989(78)80008-3
---------- MLA ----------
Izquierdo, J.A., Savini, C., Borghi, E., Rabiller, G., Costas, S., Justel, E. "Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin" . Pharmacological Research Communications, vol. 10, no. 7, 1978, pp. 643-656.
http://dx.doi.org/10.1016/S0031-6989(78)80008-3
---------- VANCOUVER ----------
Izquierdo, J.A., Savini, C., Borghi, E., Rabiller, G., Costas, S., Justel, E. Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin. Pharmacol. Res. Commun. 1978;10(7):643-656.
http://dx.doi.org/10.1016/S0031-6989(78)80008-3