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Abstract:

Over the last years, increasing evidence has fuelled the hypothesis that Autism Spectrum Disorder (ASD) is a condition of altered brain functional connectivity. The great majority of these empirical studies relies on functional magnetic resonance imaging (fMRI) which has a relatively poor temporal resolution. Only a handful of studies has examined networks emerging from dynamic coherence at the millisecond resolution and there are no investigations of coherence at the lowest frequencies in the power spectrum-which has recently been shown to reflect long-range cortico-cortical connections. Here we used electroencephalography (EEG) to assess dynamic brain connectivity in ASD focusing in the low-frequency (delta) range. We found that connectivity patterns were distinct in ASD and control populations and reflected a double dissociation: ASD subjects lacked long-range connections, with a most prominent deficit in fronto-occipital connections. Conversely, individuals with ASD showed increased short-range connections in lateral-frontal electrodes. This effect between categories showed a consistent parametric dependency: as ASD severity increased, short-range coherence was more pronounced and long-range coherence decreased. Theoretical arguments have been proposed arguing that distinct patterns of connectivity may result in networks with different efficiency in transmission of information. We show that the networks in ASD subjects have less Clustering coefficient, greater Characteristic Path Length than controls - indicating that the topology of the network departs from small-world behaviour - and greater modularity. Together these results show that delta-band coherence reveal qualitative and quantitative aspects associated with ASD pathology. © 2010 Elsevier Ltd.

Registro:

Documento: Artículo
Título:A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections
Autor:Barttfeld, P.; Wicker, B.; Cukier, S.; Navarta, S.; Lew, S.; Sigman, M.
Filiación:Integrative Neuroscience Laboratory, Physics Department, University of Buenos Aires, Buenos Aires, Argentina
Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia, Buenos Aires, Argentina
Mediterranean Institute of Cognitive Neurosciences, Centre National de la Recherche Scientifique, Université de la Méditerranée, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
Instituto de Ingeniería Biomédica, Facultad de Ingeniería, Universidad of Buenos Aires, Argentina
Palabras clave:Autism Spectrum Disorder; Delta band EEG; Functional connectivity; Resting state; Small world metrics; adolescent; adult; article; autism; brain function; calculation; clinical article; controlled study; disease severity; electroencephalography; female; frontal lobe; functional assessment; functional magnetic resonance imaging; human; male; occipital cortex; Adolescent; Adult; Asperger Syndrome; Autistic Disorder; Brain Mapping; Cerebral Cortex; Delta Rhythm; Electroencephalography; Female; Humans; Male; Nerve Net; Neural Pathways; Young Adult
Año:2011
Volumen:49
Número:2
Página de inicio:254
Página de fin:263
DOI: http://dx.doi.org/10.1016/j.neuropsychologia.2010.11.024
Título revista:Neuropsychologia
Título revista abreviado:Neuropsychologia
ISSN:00283932
CODEN:NUPSA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283932_v49_n2_p254_Barttfeld

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Citas:

---------- APA ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S. & Sigman, M. (2011) . A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections. Neuropsychologia, 49(2), 254-263.
http://dx.doi.org/10.1016/j.neuropsychologia.2010.11.024
---------- CHICAGO ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Sigman, M. "A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections" . Neuropsychologia 49, no. 2 (2011) : 254-263.
http://dx.doi.org/10.1016/j.neuropsychologia.2010.11.024
---------- MLA ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Sigman, M. "A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections" . Neuropsychologia, vol. 49, no. 2, 2011, pp. 254-263.
http://dx.doi.org/10.1016/j.neuropsychologia.2010.11.024
---------- VANCOUVER ----------
Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., Sigman, M. A big-world network in ASD: Dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections. Neuropsychologia. 2011;49(2):254-263.
http://dx.doi.org/10.1016/j.neuropsychologia.2010.11.024