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Abstract:

Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as a neuroregulator to integrate the complex neuroendocrine, autonomic, and behavioral adaptive response to stress. Hyperactive and/or dysregulated CRH circuits are involved in neuroendocrinological disturbances and stress-related mood disorders such as anxiety and depression. This review describes the main physiological features of the CRH network and summarizes recent relevant information concerning the molecular mechanism of CRH action obtained from signal transduction studies using cells and wild-type and transgenic mice lines. Special focus is placed on the MAPK signaling pathways triggered by CRH through the CRH receptor 1 that plays an essential role in CRH action in pituitary corticotrophs and in specific brain structures. Recent findings underpin the concept of specific CRH-signaling pathways restricted to specific anatomical areas. Understanding CRH action at molecular levels will not only provide insight into the precise CRH mechanism of action, but will also be instrumental in identifying novel targets for pharmacological intervention in neuroendocrine tissues and specific brain areas involved in CRH-related disorders. Copyright © 2011 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
Autor:Bonfiglio, J.J.; Inda, C.; Refojo, D.; Holsboer, F.; Arzt, E.; Silberstein, S.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología y Biología Molecular y Celular, FCEN Universidad de Buenos Aires, Buenos Aires 1428, Argentina
Max Planck Institute of Psychiatry, Munich, Germany
Palabras clave:B-Raf; CRH receptor; CRH signaling; HPA axis; MAPK; corticotropin releasing factor; mitogen activated protein kinase; anxiety; article; depression; human; hypothalamus hypophysis adrenal system; mood disorder; nonhuman; priority journal; signal transduction; stress; Animals; Central Nervous System; Corticotropin-Releasing Hormone; Humans; Hypothalamo-Hypophyseal System; Mice; Models, Animal; Pituitary-Adrenal System; Receptors, Corticotropin-Releasing Hormone; Signal Transduction
Año:2011
Volumen:94
Número:1
Página de inicio:12
Página de fin:20
DOI: http://dx.doi.org/10.1159/000328226
Título revista:Neuroendocrinology
Título revista abreviado:Neuroendocrinology
ISSN:00283835
CODEN:NUNDA
CAS:corticotropin releasing factor, 178359-01-8, 79804-71-0, 86297-72-5, 86784-80-7, 9015-71-8; mitogen activated protein kinase, 142243-02-5; Corticotropin-Releasing Hormone, 9015-71-8; Receptors, Corticotropin-Releasing Hormone
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v94_n1_p12_Bonfiglio

Referencias:

  • Vale, W., Spiess, J., Rivier, C., Rivier, J., Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin (1981) Science, 213 (4514), pp. 1394-1397
  • De Kloet, E.R., Joels, M., Holsboer, F., Stress and the brain: From adaptation to disease (2005) Nature Reviews Neuroscience, 6 (6), pp. 463-475. , DOI 10.1038/nrn1683
  • Smith, S.M., Vale, W.W., The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress (2006) Dialogues in Clinical Neuroscience, 8 (4), pp. 383-395
  • Holsboer, F., Ising, M., Stress hormone regulation: Biological role and translation into therapy (2010) Annu Rev Psychol, 61 (81-109), pp. C101-C111
  • Hillhouse, E.W., Grammatopoulos, D.K., The molecular mechanisms underlying the regulation of the biological activity of corticotropin- releasing hormone receptors: Implications for physiology and pathophysiology (2006) Endocr Rev, 27, pp. 260-286
  • Del Rey, A., Besedovsky, H.O., The cytokine- HPA axis circuit contributes to prevent or moderate autoimmune processes (2000) Z Rheumatol, 59 (SUPPL. 2), pp. II31-35
  • Swanson, L.W., Sawchenko, P.E., Rivier, J., Vale, W.W., Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study (1983) Neuroendocrinology, 36 (3), pp. 165-186
  • Bale, T.L., Vale, W.W., CRF and CRF receptors: Role in stress responsivity and other behaviors (2004) Annual Review of Pharmacology and Toxicology, 44, pp. 525-557. , DOI 10.1146/annurev.pharmtox.44.101802.121410
  • Korosi, A., Baram, T.Z., The central corticotropin releasing factor system during development and adulthood (2008) Eur J Pharmacol, 583, pp. 204-214
  • Steckler, T., Holsboer, F., Corticotropin-releasing hormone receptor subtypes and emotion (1999) Biol Psychiatry, 46, pp. 1480-1508
  • Gallagher, J.P., Orozco-Cabal, L.F., Liu, J., Shinnick-Gallagher, P., Synaptic physiology of central CRH system (2008) Eur J Pharmacol, 583, pp. 215-225
  • Reul, J.M., Holsboer, F., Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression (2002) Curr Opin Pharmacol, 2, pp. 23-33
  • Arborelius, L., Owens, M.J., Plotsky, P.M., Nemeroff, C.B., The role of corticotropin-releasing factor in depression and anxiety disorders (1999) Journal of Endocrinology, 160 (1), pp. 1-12. , DOI 10.1677/joe.0.1600001
  • Holsboer, F., The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety (1999) Journal of Psychiatric Research, 33 (3), pp. 181-214. , DOI 10.1016/S0022-3956(98)90056-5, PII S0022395698000569
  • Smith, G.W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L.M., Gold, L.H., Chen, R., Lee, K.-F., Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development (1998) Neuron, 20 (6), pp. 1093-1102. , DOI 10.1016/S0896-6273(00)80491-2
  • Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J.M.H.M., Stalla, G.K., Blanquet, V., Wurst, W., Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1 (1998) Nature Genetics, 19 (2), pp. 162-166. , DOI 10.1038/520
  • Muller, M.B., Zimmermann, S., Sillaber, I., Hagemeyer, T.P., Deussing, J.M., Timpl, P., Kormann, M.S.D., Wurst, W., Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress (2003) Nature Neuroscience, 6 (10), pp. 1100-1107. , DOI 10.1038/nn1123
  • Grigoriadis, D.E., The corticotropin-releasing factor receptor: A novel target for the treatment of depression and anxiety-related disorders (2005) Expert Opinion on Therapeutic Targets, 9 (4), pp. 651-684. , DOI 10.1517/14728222.9.4.651
  • Hauger, R.L., Risbrough, V., Brauns, O., Dautzenberg, F.M., Corticotropin releasing factor (CFR) receptor signaling in the central nervous system: New molecular targets (2006) CNS and Neurological Disorders - Drug Targets, 5 (4), pp. 453-479. , http://www.ingentaconnect.com/content/ben/cnsnddt/2006/00000005/00000004/ art00010
  • Holsboer, F., Ising, M., Central CRH system in depression and anxiety - evidence from clinical studies with CRH1 receptor antagonists (2008) Eur J Pharmacol, 583, pp. 350-357
  • Markovic, D., Grammatopoulos, D.K., Focus on the splicing of secretin GPCRs transmembrane- domain 7 (2009) Trends Biochem Sci, 34, pp. 443-452
  • Zmijewski, M.A., Slominski, A.T., Emerging role of alternative splicing of CRF1 receptor in CRF signaling (2010) Acta Biochim Pol, 57, pp. 1-13
  • Chen, A., Perrin, M., Brar, B., Li, C., Jamieson, P., DiGruccio, M., Lewis, K., Vale, W., Mouse corticotropin-releasing factor receptor type 2α gene: Isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids (2005) Molecular Endocrinology, 19 (2), pp. 441-458. , DOI 10.1210/me.2004-0300
  • Mikhailova, M.V., Mayeux, P.R., Jurkevich, A., Kuenzel, W.J., Madison, F., Periasamy, A., Chen, Y., Cornett, L.E., Heterooligomerization between vasotocin and Corticotropin-Releasing Hormone (CRH) receptors augments CRH-stimulated 3′,5′-cyclic adenosine monophosphate production (2007) Molecular Endocrinology, 21 (9), pp. 2178-2188. , http://mend.endojournals.org/cgi/reprint/21/9/2178, DOI 10.1210/me.2007-0160
  • Young, S.F., Griffante, C., Aguilera, G., Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors (2007) Cellular and Molecular Neurobiology, 27 (4), pp. 439-461. , DOI 10.1007/s10571-006-9135-8
  • Dautzenberg, F.M., Hauger, R.L., The CRF peptide family and their receptors: Yet more partners discovered (2002) Trends in Pharmacological Sciences, 23 (2), pp. 71-77. , DOI 10.1016/S0165-6147(02)01946-6, PII S0165614700019465
  • Brar, B.K., Chen, A., Perrin, M.H., Vale, W., Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2β by the CRF/urocortin family of peptides (2004) Endocrinology, 145 (4), pp. 1718-1729. , DOI 10.1210/en.2003-1023
  • Lefkowitz, R.J., Shenoy, S.K., Transduction of receptor signals by beta-arrestins (2005) Science, 308, pp. 512-517
  • Arzt, E., Holsboer, F., CRF signaling: Molecular specificity for drug targeting in the CNS (2006) Trends in Pharmacological Sciences, 27 (10), pp. 531-538. , DOI 10.1016/j.tips.2006.08.007, PII S0165614706002033
  • Maira, M., Martens, C., Philips, A., Drouin, J., Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation (1999) Molecular and Cellular Biology, 19 (11), pp. 7549-7557
  • Maira, M., Martens, C., Batsche, E., Gauthier, Y., Drouin, J., Dimer-specific potentiation of NGFI-B (Nur77) transcriptional activity by the protein kinase A pathway and AF-1-dependent coactivator recruitment (2003) Molecular and Cellular Biology, 23 (3), pp. 763-776. , DOI 10.1128/MCB.23.3.763-776.2003
  • Kovalovsky, D., Refojo, D., Liberman, A.C., Hochbaum, D., Pereda, M.P., Coso, O.A., Stalla, G.K., Arzt, E., Activation and induction of Nur77/Nurr1 in corticotrophs by CRH/cAMP: Involvement of calcium, protein kinase a, and MAPK pathways (2002) Molecular Endocrinology, 16 (7), pp. 1638-1651. , DOI 10.1210/me.16.7.1638
  • Martens, C., Bilodeau, S., Maira, M., Gauthier, Y., Drouin, J., Protein-protein interactions and transcriptional antagonism between the subfamily of NGFI-B/Nur77 orphan nuclear receptors and glucocorticoid receptor (2005) Molecular Endocrinology, 19 (4), pp. 885-897. , DOI 10.1210/me.2004-0333
  • Bilodeau, S., Vallette-Kasic, S., Gauthier, Y., Figarella-Branger, D., Brue, T., Berthelet, F., Lacroix, A., Drouin, J., Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease (2006) Genes and Development, 20 (20), pp. 2871-2886. , http://www.genesdev.org/cgi/reprint/20/20/2871, DOI 10.1101/gad.1444606
  • Giacomini, D., Paez-Pereda, M., Theodoropoulou, M., Labeur, M., Refojo, D., Gerez, J., Chervin, A., Arzt, E., Bone morphogenetic protein-4 inhibits corticotroph tumor cells: Involvement in the retinoic acid inhibitory action (2006) Endocrinology, 147 (1), pp. 247-256. , http://endo.endojournals.org/cgi/reprint/147/1/247, DOI 10.1210/en.2005-0958
  • Castillo, V., Giacomini, D., Paez-Pereda, M., Stalla, J., Labeur, M., Theodoropoulou, M., Holsboer, F., Arzt, E., Retinoic acid as a novel medical therapy for Cushing's disease in dogs (2006) Endocrinology, 147 (9), pp. 4438-4444. , http://endo.endojournals.org/cgi/reprint/147/9/4438, DOI 10.1210/en.2006-0414
  • Tsukamoto, N., Otsuka, F., Miyoshi, T., Yamanaka, R., Inagaki, K., Yamashita, M., Otani, H., Makino, H., Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope cells: Involvement of up-regulation of BMP receptor signaling by somatostatin analogs (2010) Endocrinology, 151, pp. 1129-1141
  • Cibelli, G., Corsi, P., Diana, G., Vitiello, F., Thiel, G., Corticotropin-releasing factor triggers neurite outgrowth of a catecholaminergic immortalized neuron via cAMP and MAP kinase signalling pathways (2001) European Journal of Neuroscience, 13 (7), pp. 1339-1348. , DOI 10.1046/j.0953-816X.2001.01510.x
  • Teli, T., Markovic, D., Hewitt, M.E., Levine, M.A., Hillhouse, E.W., Grammatopoulos, D.K., Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1β and response to PKC phosphorylation (2008) Cellular Signalling, 20 (1), pp. 40-49. , DOI 10.1016/j.cellsig.2007.08.014, PII S0898656807002586
  • Grammatopoulos, D.K., Randeva, H.S., Levine, M.A., Katsanou, E.S., Hillhouse, E.W., Urocortin, but not corticotropin-releasing hormone (CRH), activates the mitogen-activated protein kinase signal transduction pathway in human pregnant myometrium: An effect mediated via R1alpha and R2beta CRH receptor subtypes and stimulation of Gq-proteins (2000) Mol Endocrinol, 14, pp. 2076-2091
  • Punn, A., Levine, M.A., Grammatopoulos, D.K., Identification of signaling molecules mediating corticotropin-releasing hormone-R1α-mitogen-activated protein kinase (MAPK) interactions: The critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation (2006) Molecular Endocrinology, 20 (12), pp. 3179-3195. , http://mend.endojournals.org/cgi/reprint/20/12/3179, DOI 10.1210/me.2006-0255
  • Teli, T., Markovic, D., Levine, M.A., Hillhouse, E.W., Grammatopoulos, D.K., Regulation of corticotropin-releasing hormone receptor type 1α signaling: Structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization (2005) Molecular Endocrinology, 19 (2), pp. 474-490. , DOI 10.1210/me.2004-0275
  • Holmes, K.D., Babwah, A.V., Dale, L.B., Poulter, M.O., Ferguson, S.S., Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases (2006) J Neurochem, 96, pp. 934-949
  • Magalhaes, A.C., Holmes, K.D., Dale, L.B., Comps-Agrar, L., Lee, D., Yadav, P.N., Drysdale, L., Ferguson, S.S., CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling (2010) Nat Neurosci, 13, pp. 622-629
  • Thomas, G.M., Huganir, R.L., MAPK cascade signalling and synaptic plasticity (2004) Nature Reviews Neuroscience, 5 (3), pp. 173-183
  • Einat, H., Yuan, P., Gould, T.D., Li, J., Du, J., Zhang, L., Manji, H.K., Chen, G., The role of the extracellular signal-regulated kinase signaling pathway in mood modulation (2003) Journal of Neuroscience, 23 (19), pp. 7311-7316
  • Stork, P.J.S., Schmitt, J.M., Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation (2002) Trends in Cell Biology, 12 (6), pp. 258-266. , DOI 10.1016/S0962-8924(02)02294-8, PII S0962892402022948
  • Van Kolen, K., Dautzenberg, F.M., Verstraeten, K., Royaux, I., De Hoogt, R., Gutknecht, E., Peeters, P.J., Corticotropin releasing factorinduced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2 (2010) Neuropharmacology, 58, pp. 135-144
  • Refojo, D., Echenique, C., Muller, M.B., Reul, J.M.H.M., Deussing, J.M., Wurst, W., Sillaber, I., Arzt, E., Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas (2005) Proceedings of the National Academy of Sciences of the United States of America, 102 (17), pp. 6183-6188. , DOI 10.1073/pnas.0502070102
  • Wiese, S., Pei, G., Karch, C., Troppmair, J., Holtmann, B., Rapp, U.R., Sendtner, M., Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons (2001) Nature Neuroscience, 4 (2), pp. 137-142. , DOI 10.1038/83960
  • Bonfiglio, J.J., Maccarrone, G., Rewerts, C., Holsboer, F., Arzt, E., Turck, C.W., Silberstein, S., Characterization of the B-Raf interactome in mouse hippocampal neuronal cells (2010) J Proteomics, 74, pp. 186-198
  • Stenzel-Poore, M.P., Cameron, V.A., Vaughan, J., Sawchenko, P.E., Vale, W., Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice (1992) Endocrinology, 130, pp. 3378-3386
  • Groenink, L., Dirks, A., Verdouw, P.M., Schipholt, M.L., Veening, J.G., Van Der Gugten, J., Olivier, B., HPA axis dysregulation in mice overexpressing corticotropin releasing hormone (2002) Biological Psychiatry, 51 (11), pp. 875-881. , DOI 10.1016/S0006-3223(02)01334-3, PII S0006322302013343
  • Lu, A., Steiner, M.A., Whittle, N., Vogl, A.M., Walser, S.M., Ableitner, M., Refojo, D., Deussing, J.M., Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior (2008) Mol Psychiatry, 13, pp. 1028-1042
  • Kimura, M., Muller-Preuss, P., Lu, A., Wiesner, E., Flachskamm, C., Wurst, W., Holsboer, F., Deussing, J.M., Conditional corticotropinreleasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep (2010) Mol Psychiatry, 15, pp. 154-165
  • Refojo, D., Holsboer, F., CRH signaling Molecular specificity for drug targeting in the CNS (2009) Ann NY Acad Sci, 1179, pp. 106-119
  • Silberstein, S., Vogl, A.M., Refojo, D., Senin, S.A., Wurst, W., Holsboer, F., Deussing, J.M., Arzt, E., Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions (2009) Neuroscience, 159, pp. 610-617
  • Reyes, B.A., Valentino, R.J., Van Bockstaele, E.J., Stress-induced intracellular trafficking of corticotropin-releasing factor receptors in rat locus coeruleus neurons (2008) Endocrinology, 149, pp. 122-130
  • Waselus, M., Nazzaro, C., Valentino, R.J., Van Bockstaele, E.J., Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus (2009) Biol Psychiatry, 66, pp. 76-83

Citas:

---------- APA ----------
Bonfiglio, J.J., Inda, C., Refojo, D., Holsboer, F., Arzt, E. & Silberstein, S. (2011) . The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved. Neuroendocrinology, 94(1), 12-20.
http://dx.doi.org/10.1159/000328226
---------- CHICAGO ----------
Bonfiglio, J.J., Inda, C., Refojo, D., Holsboer, F., Arzt, E., Silberstein, S. "The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved" . Neuroendocrinology 94, no. 1 (2011) : 12-20.
http://dx.doi.org/10.1159/000328226
---------- MLA ----------
Bonfiglio, J.J., Inda, C., Refojo, D., Holsboer, F., Arzt, E., Silberstein, S. "The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved" . Neuroendocrinology, vol. 94, no. 1, 2011, pp. 12-20.
http://dx.doi.org/10.1159/000328226
---------- VANCOUVER ----------
Bonfiglio, J.J., Inda, C., Refojo, D., Holsboer, F., Arzt, E., Silberstein, S. The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved. Neuroendocrinology. 2011;94(1):12-20.
http://dx.doi.org/10.1159/000328226