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Abstract:

Salt appetite, a conditioning factor for hypertension and cardiovascular diseases, is produced when high doses of mineralocorticoids are given to experimental animals. A commonly used procedure to identify neuronal activation is to determine the number of Fos-immunoreactive cells. In rats with established salt appetite after 8 days of deoxycorticosterone acetate (DOCA) treatment, Fos-positive cells were studied in seven brain areas. Significant increases in Fos activity were recorded in the paraventricular (PVN) and supraoptic (SON) nuclei, median preoptic nucleus (MnPO), organum vasculosum of the lamina terminalis (OVLT), preoptic area (POA), bed nucleus of the stria terminalis (BNST) and amygdala (AMYG). In most of these areas, increased Fos expression was also observed early (2 h) after a single DOCA injection, well before salt appetite develops. Using a mineralocorticoid receptor (MR) antibody, we studied whether Fos-active regions also expressed MR. MR-positive cells were found in the OVLT, MnPO, AMYG and BNST, but not in the POA, PVN and SON. In the PVN and SON, nevertheless, prolonged or single DOCA treatment increased expression of mRNA for arginine vasopressin (AVP). The present demonstration of Fos activation, in conjunction with differential expression of MR and stimulation of AVP mRNA, suggests that a neuroanatomical pathway comprising the AMYG, osmosensitive brain regions and magnocellular nuclei becomes activated during DOCA effects on salt appetite. It is recognized, however, that DOCA effects may also depend on mechanisms and brain structures other than those considered in the present investigation. Since some Fos-positive regions were devoid of MR, a comprehensive view of DOCA-induced salt appetite should consider nonge-nomic pathways of steroid action, including the role of reduced DOC metabolites binding to GABAergic membrane receptors. Copyright © 2001 S. Karger AG, Basel.

Registro:

Documento: Artículo
Título:Changes in fos expression in various brain regions during deoxycorticosterone acetate treatment: Relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor
Autor:Pietranera, L.; Saravia, F.E.; Mcewen, B.S.; Lucas, L.L.; Johnson, A.K.; De Nicola, A.F.
Filiación:Instituto de Biologia y Medicina Experimental, Department of Human Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
Instituto Universitario de Ciencias de la Salud, Fundación Barceló, Buenos Aires, Argentina
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, United States
Department of Psychology and Pharmacology, Cardiovascular Center, University of Iowa, Iowa City, IA, United States
Laboratory of Neuroendocrine Biochemistry, Institute of Biology and Experimental Medicine, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Adrenal steroid receptors; Adrenal steroids; Amygdala; Fos; Organum vasculosum laminae terminalis; Paraventricular nucleus; Salt appetite; Supraoptic nucleus; Vasopressin; 4 aminobutyric acid receptor; argipressin; deoxycorticosterone acetate; membrane receptor; mineralocorticoid receptor; protein fos; sodium chloride; vasopressin; amygdaloid nucleus; animal cell; animal experiment; animal tissue; article; brain region; cardiovascular disease; cell activation; controlled study; drug binding; drug mechanism; hypertension; male; nonhuman; preoptic area; preoptic nucleus; priority journal; protein expression; rat; sodium appetite; stria terminalis; supraoptic nucleus; thalamus midline nucleus; Non-programmatic; Animals; Appetite; Arginine Vasopressin; Brain; Desoxycorticosterone; Immunohistochemistry; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; RNA, Messenger; Sodium Chloride; Tissue Distribution
Año:2001
Volumen:74
Número:6
Página de inicio:396
Página de fin:406
DOI: http://dx.doi.org/10.1159/000054706
Título revista:Neuroendocrinology
Título revista abreviado:Neuroendocrinology
ISSN:00283835
CODEN:NUNDA
CAS:Arginine Vasopressin, 113-79-1; Desoxycorticosterone, 64-85-7; Proto-Oncogene Proteins c-fos; Receptors, Mineralocorticoid; RNA, Messenger; Sodium Chloride, 7647-14-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v74_n6_p396_Pietranera

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Citas:

---------- APA ----------
Pietranera, L., Saravia, F.E., Mcewen, B.S., Lucas, L.L., Johnson, A.K. & De Nicola, A.F. (2001) . Changes in fos expression in various brain regions during deoxycorticosterone acetate treatment: Relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor. Neuroendocrinology, 74(6), 396-406.
http://dx.doi.org/10.1159/000054706
---------- CHICAGO ----------
Pietranera, L., Saravia, F.E., Mcewen, B.S., Lucas, L.L., Johnson, A.K., De Nicola, A.F. "Changes in fos expression in various brain regions during deoxycorticosterone acetate treatment: Relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor" . Neuroendocrinology 74, no. 6 (2001) : 396-406.
http://dx.doi.org/10.1159/000054706
---------- MLA ----------
Pietranera, L., Saravia, F.E., Mcewen, B.S., Lucas, L.L., Johnson, A.K., De Nicola, A.F. "Changes in fos expression in various brain regions during deoxycorticosterone acetate treatment: Relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor" . Neuroendocrinology, vol. 74, no. 6, 2001, pp. 396-406.
http://dx.doi.org/10.1159/000054706
---------- VANCOUVER ----------
Pietranera, L., Saravia, F.E., Mcewen, B.S., Lucas, L.L., Johnson, A.K., De Nicola, A.F. Changes in fos expression in various brain regions during deoxycorticosterone acetate treatment: Relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor. Neuroendocrinology. 2001;74(6):396-406.
http://dx.doi.org/10.1159/000054706