We have studied the effect of superior spermatic nerve (SSN) section on testicular gonadotropin receptors and in vitro androgen production by immature rat testis. Bilateral testicular denervation had no effect on testicular weight, serum androgens, LH, FSH and PRL levels. Denervation resulted in a significant inhibition of hCG stimulated in vitro androgen production. A reduction in the number of testicular LH receptors was observed after SSN section, while FSH binding sites remained unchanged. These results indicate that the number of LH receptors and testicular steroidogenic response to hCG are influenced by nerves reaching the testis.
Documento: | Artículo |
Título: | Effect of bilateral denervation of the immature rat testis on testicular gonadotropin receptors and in vitro |
Autor: | Campos, M.B.; Chiocchio, S.R.; Calandra, R.S.; Ritta, M.N. |
Filiación: | Inst Biologia Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina |
Palabras clave: | Androgen production; Gonadotropin receptors; Testicular denervation; Testis; chorionic gonadotropin; follitropin receptor; gonadotropin receptor; iodine 125; luteinizing hormone receptor; membrane receptor; androgen blood level; androgen synthesis; animal cell; animal tissue; article; controlled study; denervation; follitropin blood level; hormone inhibition; immaturity; isotope labeling; luteinizing hormone blood level; male; nerve transection; nonhuman; priority journal; prolactin blood level; radioimmunoassay; rat; spermatozoon; steroidogenesis; testis; testis development; testis weight; testosterone blood level |
Año: | 1993 |
Volumen: | 57 |
Número: | 2 |
Página de inicio: | 189 |
Página de fin: | 194 |
DOI: | http://dx.doi.org/10.1159/000126359 |
Título revista: | Neuroendocrinology |
Título revista abreviado: | NEUROENDOCRINOLOGY |
ISSN: | 00283835 |
CODEN: | NUNDA |
CAS: | chorionic gonadotropin, 9002-61-3; iodine 125, 14158-31-7, 22822-81-7 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v57_n2_p189_Campos |