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Abstract:

In the isolated rat hypothalamus preincubated with 3H-noradrenaline, an extract from the venom glands of Latrodectus mactans elicited an overflow of tritium which consisted of 70-71% 3H-noradrenaline and 18% 3H-3,4-dihydroxyphenylglycol. Exposure to cocaine or pargyline diminished the formation of 3H-3,4-dihydroxyphenylglycol, suggesting that the glycol is formed presynaptically after neuronal reuptake of the transmitter released by the venom. Our data suggest that the venom depolarizes the noradrenergic neurones of rat hypothalamus, and that the depolarization leads to calcium-dependent release of 3H-noradrenaline. © 1980 Springer-Verlag.

Registro:

Documento: Artículo
Título:Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands
Autor:Fernández Pardal, J.; Granata, A.R.; Barrio, A.; Gimeno, A.L.
Filiación:Centro Nacional de Investigaciones Iológicas (CENAI), Consejo Nacional de Investigaciones Científicas y Técnicas, de la República Argentina (CONICET), Serrano 665, Buenos Aires, 1414, Argentina
Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET, V. de Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:Black widow spider venom; Noradrenaline metabolism; Rat hypothalamus; calcium; cocaine; nicotine; noradrenalin; pargyline; radioisotope; spider venom; tetrodotoxin; tyramine; arthropod venom; noradrenalin; spider venom; tetrodotoxin; animal experiment; arthropod; central nervous system; controlled study; drug response; hypothalamus; in vitro study; metabolism; noradrenalin h 3; noradrenergic system; rat; animal; article; hypothalamus; metabolism; spider; Animal; Arthropod Venoms; Black Widow Spider; Hypothalamus; In Vitro; Norepinephrine; Rats; Spider Venoms; Support, Non-U.S. Gov't; Tetrodotoxin
Año:1980
Volumen:313
Número:1
Página de inicio:27
Página de fin:31
DOI: http://dx.doi.org/10.1007/BF00505801
Título revista:Naunyn-Schmiedeberg's Archives of Pharmacology
Título revista abreviado:Naunyn-Schmiedeberg's Arch. Pharmacol.
ISSN:00281298
CODEN:NSAPC
CAS:calcium, 7440-70-2; cocaine, 50-36-2, 53-21-4, 5937-29-1; nicotine, 54-11-5; noradrenalin, 1407-84-7, 51-41-2; pargyline, 306-07-0, 555-57-7; tetrodotoxin, 4368-28-9, 4664-41-9; tyramine, 51-67-2, 60-19-5; Arthropod Venoms; Norepinephrine, 51-41-2; Spider Venoms; Tetrodotoxin, 4368-28-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00281298_v313_n1_p27_FernandezPardal

Referencias:

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Citas:

---------- APA ----------
Fernández Pardal, J., Granata, A.R., Barrio, A. & Gimeno, A.L. (1980) . Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands. Naunyn-Schmiedeberg's Archives of Pharmacology, 313(1), 27-31.
http://dx.doi.org/10.1007/BF00505801
---------- CHICAGO ----------
Fernández Pardal, J., Granata, A.R., Barrio, A., Gimeno, A.L. "Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands" . Naunyn-Schmiedeberg's Archives of Pharmacology 313, no. 1 (1980) : 27-31.
http://dx.doi.org/10.1007/BF00505801
---------- MLA ----------
Fernández Pardal, J., Granata, A.R., Barrio, A., Gimeno, A.L. "Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands" . Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 313, no. 1, 1980, pp. 27-31.
http://dx.doi.org/10.1007/BF00505801
---------- VANCOUVER ----------
Fernández Pardal, J., Granata, A.R., Barrio, A., Gimeno, A.L. Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands. Naunyn-Schmiedeberg's Arch. Pharmacol. 1980;313(1):27-31.
http://dx.doi.org/10.1007/BF00505801