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Houbaert, A.; Zhang, C.; Tiwari, M.; Wang, K.; de Marcos Serrano, A.; Savatin, D.V.; Urs, M.J.; Zhiponova, M.K.; Gudesblat, G.E.; Vanhoutte, I.; Eeckhout, D.; Boeren, S.; Karimi, M.; Betti, C.; Jacobs, T.; Fenoll, C.; Mena, M.; de Vries, S. (...) Russinova, E. "POLAR-guided signalling complex assembly and localization drive asymmetric cell division" (2018) Nature. 563(7732):574-578
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Abstract:

Stomatal cell lineage is an archetypal example of asymmetric cell division (ACD), which is necessary for plant survival 1–4 . In Arabidopsis thaliana, the GLYCOGEN SYNTHASE KINASE3 (GSK3)/SHAGGY-like kinase BRASSINOSTEROID INSENSITIVE 2 (BIN2) phosphorylates both the mitogen-activated protein kinase (MAPK) signalling module 5,6 and its downstream target, the transcription factor SPEECHLESS (SPCH) 7 , to promote and restrict ACDs, respectively, in the same stomatal lineage cell. However, the mechanisms that balance these mutually exclusive activities remain unclear. Here we identify the plant-specific protein POLAR as a stomatal lineage scaffold for a subset of GSK3-like kinases that confines them to the cytosol and subsequently transiently polarizes them within the cell, together with BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE (BASL), before ACD. As a result, MAPK signalling is attenuated, enabling SPCH to drive ACD in the nucleus. Moreover, POLAR turnover requires phosphorylation on specific residues, mediated by GSK3. Our study reveals a mechanism by which the scaffolding protein POLAR ensures GSK3 substrate specificity, and could serve as a paradigm for understanding regulation of GSK3 in plants. © 2018, Springer Nature Limited.

Registro:

Documento: Artículo
Título:POLAR-guided signalling complex assembly and localization drive asymmetric cell division
Autor:Houbaert, A.; Zhang, C.; Tiwari, M.; Wang, K.; de Marcos Serrano, A.; Savatin, D.V.; Urs, M.J.; Zhiponova, M.K.; Gudesblat, G.E.; Vanhoutte, I.; Eeckhout, D.; Boeren, S.; Karimi, M.; Betti, C.; Jacobs, T.; Fenoll, C.; Mena, M.; de Vries, S.; De Jaeger, G.; Russinova, E.
Filiación:Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium
Center for Plant Systems Biology, VIB, Ghent, Belgium
College of Life Sciences, Wuhan University, Wuhan, China
Facultad de Ciencias Ambientales y Bioquíımica, Universidad de Castilla-la Mancha, Toledo, Spain
Laboratory of Biochemistry, Wageningen University, Wageningen, Netherlands
Department of Plant Physiology, Biological Faculty, University of Sofia, Sofia, Bulgaria
Instituto de Biodiversidad y Biología Experimental y Aplicada, Departamento de Fisiología, Biología Molecular y Celular, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Medicine, University of Perugia, Perugia, Italy
Palabras clave:BIN2 protein; glycogen synthase kinase 3; mitogen activated protein kinase; plant protein; POLAR protein; protein kinase; SPEECHLESS protein; transcription factor; unclassified drug; Arabidopsis thaliana; asymmetric cell division; cell fate; cell lineage; cell nucleus; cellular distribution; complex formation; controlled study; cytosol; enzyme specificity; Letter; MAPK signaling; nonhuman; plant stoma; polarization; priority journal; protein expression; protein phosphorylation; signal transduction
Año:2018
Volumen:563
Número:7732
Página de inicio:574
Página de fin:578
DOI: http://dx.doi.org/10.1038/s41586-018-0714-x
Título revista:Nature
Título revista abreviado:Nature
ISSN:00280836
CODEN:NATUA
CAS:mitogen activated protein kinase, 142243-02-5; protein kinase, 9026-43-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00280836_v563_n7732_p574_Houbaert

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Citas:

---------- APA ----------
Houbaert, A., Zhang, C., Tiwari, M., Wang, K., de Marcos Serrano, A., Savatin, D.V., Urs, M.J.,..., Russinova, E. (2018) . POLAR-guided signalling complex assembly and localization drive asymmetric cell division. Nature, 563(7732), 574-578.
http://dx.doi.org/10.1038/s41586-018-0714-x
---------- CHICAGO ----------
Houbaert, A., Zhang, C., Tiwari, M., Wang, K., de Marcos Serrano, A., Savatin, D.V., et al. "POLAR-guided signalling complex assembly and localization drive asymmetric cell division" . Nature 563, no. 7732 (2018) : 574-578.
http://dx.doi.org/10.1038/s41586-018-0714-x
---------- MLA ----------
Houbaert, A., Zhang, C., Tiwari, M., Wang, K., de Marcos Serrano, A., Savatin, D.V., et al. "POLAR-guided signalling complex assembly and localization drive asymmetric cell division" . Nature, vol. 563, no. 7732, 2018, pp. 574-578.
http://dx.doi.org/10.1038/s41586-018-0714-x
---------- VANCOUVER ----------
Houbaert, A., Zhang, C., Tiwari, M., Wang, K., de Marcos Serrano, A., Savatin, D.V., et al. POLAR-guided signalling complex assembly and localization drive asymmetric cell division. Nature. 2018;563(7732):574-578.
http://dx.doi.org/10.1038/s41586-018-0714-x