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Khan, Z.U.; Koulen, P.; Rubinstein, M.; Grandy, D.K.; Goldman-Rakic, P.S. "An astroglia-linked dopamine D2-receptor action in prefrontal cortex" (2001) Proceedings of the National Academy of Sciences of the United States of America. 98(4):1964-1969
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Abstract:

Typical neuroleptic drugs elicit their antipsychotic effects mainly by acting as antagonists at dopamine D2 receptors. Much of this activity is thought to occur in the cerebral cortex, where D2 receptors are found largely in inhibitory GABAergic neurons. Here we confirm this localization at the electron microscopic level, but additionally show that a subset of cortical interneurons with low or undetectable expression of D2 receptor isoforms are surrounded by astrocytic processes that strongly express D2 receptors. Ligand binding of isolated astrocyte preparations indicate that cortical astroglia account for approximately one-third of the total D2 receptor binding sites in the cortex, a proportion that we found conserved among rodent, monkey, and human tissues. Further, we show that the D2 receptor-specific agonist, quinpirole, can induce Ca2+ elevation in isolated cortical astrocytes in a pharmacologically reversible manner, thus implicating this receptor in the signaling mechanisms by which astrocytes communicate with each other as well as with neurons. The discovery of D2 receptors in astrocytes with a selective anatomical relationship to interneurons represents a neuron/gila substrate for cortical dopamine action in the adult cerebral cortex and a previously unrecognized site of action for antipsychotic drugs with affinities at the D2 receptor.

Registro:

Documento: Artículo
Título:An astroglia-linked dopamine D2-receptor action in prefrontal cortex
Autor:Khan, Z.U.; Koulen, P.; Rubinstein, M.; Grandy, D.K.; Goldman-Rakic, P.S.
Filiación:Section of Neurobiology, Yale School of Medicine, New Haven, CT 06520-8001, United States
Department of Pharmacology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520-8001, United States
Departamento de Fisiologia y Biofisica, Facultad de Medicina, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201, United States
Palabras clave:calcium ion; dopamine 2 receptor; isoprotein; neuroleptic agent; quinpirole; animal tissue; article; astrocyte; binding site; controlled study; drug receptor binding; hormone action; human; human tissue; interneuron; macroglia; monkey; mouse; nonhuman; prefrontal cortex; priority journal; protein expression; signal transduction; species difference; Animals; Astrocytes; Binding Sites; Brain; Calcium; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Haplorhini; Humans; Ligands; Mice; Neurons; Prefrontal Cortex; Quinpirole; Raclopride; Rats; Receptors, Dopamine D2; Animalia; Gila; Rodentia
Año:2001
Volumen:98
Número:4
Página de inicio:1964
Página de fin:1969
DOI: http://dx.doi.org/10.1073/pnas.98.4.1964
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
CAS:Calcium, 7440-70-2; Dopamine Agonists; Dopamine Antagonists; Ligands; Quinpirole, 85760-74-3; Raclopride, 84225-95-6; Receptors, Dopamine D2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v98_n4_p1964_Khan

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Citas:

---------- APA ----------
Khan, Z.U., Koulen, P., Rubinstein, M., Grandy, D.K. & Goldman-Rakic, P.S. (2001) . An astroglia-linked dopamine D2-receptor action in prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America, 98(4), 1964-1969.
http://dx.doi.org/10.1073/pnas.98.4.1964
---------- CHICAGO ----------
Khan, Z.U., Koulen, P., Rubinstein, M., Grandy, D.K., Goldman-Rakic, P.S. "An astroglia-linked dopamine D2-receptor action in prefrontal cortex" . Proceedings of the National Academy of Sciences of the United States of America 98, no. 4 (2001) : 1964-1969.
http://dx.doi.org/10.1073/pnas.98.4.1964
---------- MLA ----------
Khan, Z.U., Koulen, P., Rubinstein, M., Grandy, D.K., Goldman-Rakic, P.S. "An astroglia-linked dopamine D2-receptor action in prefrontal cortex" . Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 4, 2001, pp. 1964-1969.
http://dx.doi.org/10.1073/pnas.98.4.1964
---------- VANCOUVER ----------
Khan, Z.U., Koulen, P., Rubinstein, M., Grandy, D.K., Goldman-Rakic, P.S. An astroglia-linked dopamine D2-receptor action in prefrontal cortex. Proc. Natl. Acad. Sci. U. S. A. 2001;98(4):1964-1969.
http://dx.doi.org/10.1073/pnas.98.4.1964