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Hirata, K.; Nakagawa, M.; Urbano, F.J.; Rosato-Siri, M.D.; Moreira, J.E.; Uchitel, O.D.; Sugimori, M.; Llinás, R. "Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound" (1999) Proceedings of the National Academy of Sciences of the United States of America. 96(25):14588-14593
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Abstract:

Bath application of compound T-588, a neuroprotective agent, reduced paired-pulse and repetitive-pulse facilitation at mammalian and crustacean neuromuscular junctions. In addition, it reduced voltage-gated sodium and potassium currents in a use-dependent fashion, but had only a small effect on the presynaptic Ca 2+ conductance. By contrast, it blocked FM 1-43 vesicular uptake but not its release, in both species. Postsynaptically, T-588 reduced acetylcholine currents at the mammalian junction in a voltage-independent manner, but had no effect on the crayfish glutamate junction. All of these effects were rapidly reversible and were observed at concentrations close to the compound's acute protective level. We propose that this set of mechanisms, which reduces high-frequency synaptic transmission, is an important contributory factor in the neuroprotective action of T-588.

Registro:

Documento: Artículo
Título:Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound
Autor:Hirata, K.; Nakagawa, M.; Urbano, F.J.; Rosato-Siri, M.D.; Moreira, J.E.; Uchitel, O.D.; Sugimori, M.; Llinás, R.
Filiación:Dept. of Physiology and Neuroscience, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, United States
Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930-8508, Japan
Lab. de Fisiol. y Biologia Molecular, Departamento de Ciencias Biologicas, Pabellon II-2do, 1428-Buenos Aires, Argentina
Universidade de São Paulo, Faculdade de Med. de Ribeirao Preto, Departamento de Morfologia, 14049-900 Ribeirão Preto, SP, Brazil
Palabras clave:FM 1-43; Two-photon microscopy; Ultrastructure; Voltage clamp; 1 (benzo[b]thien 5 yl) 2 (2 diethylaminoethoxy)ethanol; acetylcholine release; animal cell; article; calcium conductance; cell death; cell ultrastructure; drug effect; facilitation; mouse; nerve cell; neuromuscular synapse; neuroprotection; nonhuman; potassium current; priority journal; sodium current; synaptic transmission; Action Potentials; Animals; Astacoidea; Calcium; Diethylamines; Endocytosis; Glutamic Acid; Male; Mice; Neuromuscular Junction; Neuroprotective Agents; Potassium Channels; Sodium Channels; Synaptic Transmission; Synaptic Vesicles; Thiophenes; Animalia; Astacoidea; Crustacea; Mammalia
Año:1999
Volumen:96
Número:25
Página de inicio:14588
Página de fin:14593
DOI: http://dx.doi.org/10.1073/pnas.96.25.14588
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
CAS:Calcium, 7440-70-2; Diethylamines; Glutamic Acid, 56-86-0; Neuroprotective Agents; Potassium Channels; Sodium Channels; T 588, 142935-03-3; Thiophenes
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00278424_v96_n25_p14588_Hirata.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v96_n25_p14588_Hirata

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Citas:

---------- APA ----------
Hirata, K., Nakagawa, M., Urbano, F.J., Rosato-Siri, M.D., Moreira, J.E., Uchitel, O.D., Sugimori, M.,..., Llinás, R. (1999) . Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound. Proceedings of the National Academy of Sciences of the United States of America, 96(25), 14588-14593.
http://dx.doi.org/10.1073/pnas.96.25.14588
---------- CHICAGO ----------
Hirata, K., Nakagawa, M., Urbano, F.J., Rosato-Siri, M.D., Moreira, J.E., Uchitel, O.D., et al. "Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound" . Proceedings of the National Academy of Sciences of the United States of America 96, no. 25 (1999) : 14588-14593.
http://dx.doi.org/10.1073/pnas.96.25.14588
---------- MLA ----------
Hirata, K., Nakagawa, M., Urbano, F.J., Rosato-Siri, M.D., Moreira, J.E., Uchitel, O.D., et al. "Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound" . Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 25, 1999, pp. 14588-14593.
http://dx.doi.org/10.1073/pnas.96.25.14588
---------- VANCOUVER ----------
Hirata, K., Nakagawa, M., Urbano, F.J., Rosato-Siri, M.D., Moreira, J.E., Uchitel, O.D., et al. Reduced facilitation and vesicular uptake in crustacean and mammalian neuromuscular junction by T-588, a neuroprotective compound. Proc. Natl. Acad. Sci. U. S. A. 1999;96(25):14588-14593.
http://dx.doi.org/10.1073/pnas.96.25.14588