Artículo

Barttfelda, P.; Uhriga, L.; Sitta, J.D.; Sigmane, M.; Jarrayaa, B.; Dehaene, S. "Signature of consciousness in the dynamics of resting-state brain activity" (2015) Proceedings of the National Academy of Sciences of the United States of America. 112(3):887-892
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Abstract:

At rest, the brain is traversed by spontaneous functional connectivity patterns. Two hypotheses have been proposed for their origins: they may reflect a continuous stream of ongoing cognitive processes as well as random fluctuations shaped by a fixed anatomical connectivity matrix. Here we show that both sources contribute to the shaping of resting-state networks, yet with distinct contributions during consciousness and anesthesia. We measured dynamical functional connectivity with functional MRI during the resting state in awake and anesthetized monkeys. Under anesthesia, the more frequent functional connectivity patterns inherit the structure of anatomical connectivity, exhibit fewer small-world properties, and lack negative correlations. Conversely, wakefulness is characterized by the sequential exploration of a richer repertoire of functional configurations, often dissimilar to anatomical structure, and comprising positive and negative correlations among brain regions. These results reconcile theories of consciousness with observations of long-range correlation in the anesthetized brain and show that a rich functional dynamics might constitute a signature of consciousness, with potential clinical implications for the detection of awareness in anesthesia and brain-lesioned patients.

Registro:

Documento: Artículo
Título:Signature of consciousness in the dynamics of resting-state brain activity
Autor:Barttfelda, P.; Uhriga, L.; Sitta, J.D.; Sigmane, M.; Jarrayaa, B.; Dehaene, S.
Filiación:NeuroSpin Center, Institute of BioImaging Commissariat À l'Energie Atomique, Gif/Yvette, 91191, France
Cognitive Neuroimaging Unit, INSERM, U992, Gif/Yvette, 91191, France
Avenir-Bettencourt-Schueller Team, INSERM, Gif-sur-Yvette, 91191, France
INSERM, U1127, Institut du Cerveau et de la Moelle Épinière, Paris, F-75013, France
Laboratorio de Neurociencia Integrativa, Instituto de Física de Buenos Aires, Universidad de Buenos Aires, Buenos Aires, C1428EGA, Argentina
Universidad Torcuato di Tella, Buenos Aires, C1428BIJ, Argentina
Université Versailles Saint-Quentin-en-Yvelines, Versailles, 78000, France
Neuromodulation Unit, Department of Neurosurgery, Foch Hospital, Suresnes, 92150, France
Université Paris 11, Orsay, 92150, France
Collège de France, Paris, 92150, France
Palabras clave:Anesthesia; Consciousness; Dynamics; Functional connectivity; Structural connectivity; anatomical concepts; anesthesia; animal experiment; Article; brain region; consciousness; electroencephalogram; female; functional magnetic resonance imaging; image analysis; male; nonhuman; priority journal; resting state network; theory; wakefulness; animal; brain; brain mapping; nuclear magnetic resonance imaging; physiology; rhesus monkey; Animals; Brain; Brain Mapping; Consciousness; Macaca mulatta; Magnetic Resonance Imaging
Año:2015
Volumen:112
Número:3
Página de inicio:887
Página de fin:892
DOI: http://dx.doi.org/10.1073/pnas.1418031112
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v112_n3_p887_Barttfelda

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Citas:

---------- APA ----------
Barttfelda, P., Uhriga, L., Sitta, J.D., Sigmane, M., Jarrayaa, B. & Dehaene, S. (2015) . Signature of consciousness in the dynamics of resting-state brain activity. Proceedings of the National Academy of Sciences of the United States of America, 112(3), 887-892.
http://dx.doi.org/10.1073/pnas.1418031112
---------- CHICAGO ----------
Barttfelda, P., Uhriga, L., Sitta, J.D., Sigmane, M., Jarrayaa, B., Dehaene, S. "Signature of consciousness in the dynamics of resting-state brain activity" . Proceedings of the National Academy of Sciences of the United States of America 112, no. 3 (2015) : 887-892.
http://dx.doi.org/10.1073/pnas.1418031112
---------- MLA ----------
Barttfelda, P., Uhriga, L., Sitta, J.D., Sigmane, M., Jarrayaa, B., Dehaene, S. "Signature of consciousness in the dynamics of resting-state brain activity" . Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 3, 2015, pp. 887-892.
http://dx.doi.org/10.1073/pnas.1418031112
---------- VANCOUVER ----------
Barttfelda, P., Uhriga, L., Sitta, J.D., Sigmane, M., Jarrayaa, B., Dehaene, S. Signature of consciousness in the dynamics of resting-state brain activity. Proc. Natl. Acad. Sci. U. S. A. 2015;112(3):887-892.
http://dx.doi.org/10.1073/pnas.1418031112