Artículo

Freitag, N.; Tirado-Gonzaĺez, I.; Barrientos, G.; Herse, F.; Thijssen, V.L.J.L.; Weedon-Fekjær, S.M.; Schulz, H.; Wallukat, G.; Klapp, B.F.; Nevers, T.; Sharma, S.; Staff, A.C.; Dechend, R.; Blois, S.M. "Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia" (2013) Proceedings of the National Academy of Sciences of the United States of America. 110(28):11451-11456
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Abstract:

Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1-mediated angiogenesis or lectin, galactoside-binding, soluble, 1 deficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis.

Registro:

Documento: Artículo
Título:Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia
Autor:Freitag, N.; Tirado-Gonzaĺez, I.; Barrientos, G.; Herse, F.; Thijssen, V.L.J.L.; Weedon-Fekjær, S.M.; Schulz, H.; Wallukat, G.; Klapp, B.F.; Nevers, T.; Sharma, S.; Staff, A.C.; Dechend, R.; Blois, S.M.
Filiación:Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitätsmedizin Berlin, 13353 Berlin, Germany
Laboratorio de Fisiología Molecular Placentaria, Instituto de Química Biológica, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Experimental and Clinical Research Center, Max-Delbrück Center for Molecular Medicine, HELIOS Klinikum Berlin-Buch, 13125 Berlin, Germany
Departments of Radiation Oncology and Medical Oncology, Angiogenesis Laboratory, Vrije Universiteit University Medical Center, 1081 HV, Amsterdam, Netherlands
Department of Obstetrics and Gynecology, Oslo University Hospital, Ullevål, University of Oslo, 0450, Oslo, Norway
Max-Delbrück Center for Molecular Medicine, 13092 Berlin, Germany
Department of Pediatrics, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02912, United States
Palabras clave:galectin 1; lectin; messenger RNA; vasculotropin receptor 1; vasculotropin receptor 2; angiogenesis; animal experiment; animal tissue; article; cell adhesion; decidua; dendritic cell; down regulation; female; gene expression; mouse; nonhuman; preeclampsia; pregnancy; priority journal; signal transduction; Animals; Disease Models, Animal; Female; Galectin 1; Humans; Mice; Neovascularization, Physiologic; Placenta; Pre-Eclampsia; Pregnancy; Trophoblasts; Mus
Año:2013
Volumen:110
Número:28
Página de inicio:11451
Página de fin:11456
DOI: http://dx.doi.org/10.1073/pnas.1303707110
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
CAS:galectin 1, 258495-34-0; Galectin 1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v110_n28_p11451_Freitag

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Citas:

---------- APA ----------
Freitag, N., Tirado-Gonzaĺez, I., Barrientos, G., Herse, F., Thijssen, V.L.J.L., Weedon-Fekjær, S.M., Schulz, H.,..., Blois, S.M. (2013) . Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia. Proceedings of the National Academy of Sciences of the United States of America, 110(28), 11451-11456.
http://dx.doi.org/10.1073/pnas.1303707110
---------- CHICAGO ----------
Freitag, N., Tirado-Gonzaĺez, I., Barrientos, G., Herse, F., Thijssen, V.L.J.L., Weedon-Fekjær, S.M., et al. "Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia" . Proceedings of the National Academy of Sciences of the United States of America 110, no. 28 (2013) : 11451-11456.
http://dx.doi.org/10.1073/pnas.1303707110
---------- MLA ----------
Freitag, N., Tirado-Gonzaĺez, I., Barrientos, G., Herse, F., Thijssen, V.L.J.L., Weedon-Fekjær, S.M., et al. "Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia" . Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 28, 2013, pp. 11451-11456.
http://dx.doi.org/10.1073/pnas.1303707110
---------- VANCOUVER ----------
Freitag, N., Tirado-Gonzaĺez, I., Barrientos, G., Herse, F., Thijssen, V.L.J.L., Weedon-Fekjær, S.M., et al. Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia. Proc. Natl. Acad. Sci. U. S. A. 2013;110(28):11451-11456.
http://dx.doi.org/10.1073/pnas.1303707110