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Abstract:

In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag.

Registro:

Documento: Artículo
Título:Behavioral tagging is a general mechanism of long-term memory formation
Autor:Ballarini, F.; Moncada, D.; Martinez, M.C.; Alen, N.; Viola, H.
Filiación:Instituto de Biología Celular Y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires-CONICET, Paraguay 2155, CP 1121, Buenos Aires, Argentina
Departamento de Fisiología, Biología Molecular Y Celular, Facultad de Ciencias Exactas Y Naturales, Ciudad Universitaria, Intendente Güiraldes 2160, CP 1428, Buenos Aires, Argentina
Palabras clave:Hippocampus; Insular cortex; Memory consolidation; Novelty; Protein synthesis; animal experiment; article; behavior; conditioned reflex; conditioning; controlled study; hippocampus; learning; long term memory; male; nonhuman; open field behavior; priority journal; protein synthesis; rat; recognition; short term memory; task performance; taste aversion; training; Animals; Behavior, Animal; Conditioning (Psychology); Discrimination Learning; Fear; Hippocampus; Learning; Long-Term Potentiation; Male; Memory; Memory, Short-Term; Neocortex; Neuronal Plasticity; Psychomotor Performance; Rats; Rats, Wistar; Saccharin; Sodium Chloride; Spatial Behavior; Taste; Time Factors; Rattus
Año:2009
Volumen:106
Número:34
Página de inicio:14599
Página de fin:14604
DOI: http://dx.doi.org/10.1073/pnas.0907078106
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
CAS:Saccharin, 81-07-2; Sodium Chloride, 7647-14-5
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00278424_v106_n34_p14599_Ballarini.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v106_n34_p14599_Ballarini

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Citas:

---------- APA ----------
Ballarini, F., Moncada, D., Martinez, M.C., Alen, N. & Viola, H. (2009) . Behavioral tagging is a general mechanism of long-term memory formation. Proceedings of the National Academy of Sciences of the United States of America, 106(34), 14599-14604.
http://dx.doi.org/10.1073/pnas.0907078106
---------- CHICAGO ----------
Ballarini, F., Moncada, D., Martinez, M.C., Alen, N., Viola, H. "Behavioral tagging is a general mechanism of long-term memory formation" . Proceedings of the National Academy of Sciences of the United States of America 106, no. 34 (2009) : 14599-14604.
http://dx.doi.org/10.1073/pnas.0907078106
---------- MLA ----------
Ballarini, F., Moncada, D., Martinez, M.C., Alen, N., Viola, H. "Behavioral tagging is a general mechanism of long-term memory formation" . Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 34, 2009, pp. 14599-14604.
http://dx.doi.org/10.1073/pnas.0907078106
---------- VANCOUVER ----------
Ballarini, F., Moncada, D., Martinez, M.C., Alen, N., Viola, H. Behavioral tagging is a general mechanism of long-term memory formation. Proc. Natl. Acad. Sci. U. S. A. 2009;106(34):14599-14604.
http://dx.doi.org/10.1073/pnas.0907078106