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Gao, H.; Ayub, M.J.; Levin, M.J.; Frank, J. "The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components" (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(29):10206-10211
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Abstract:

We present analysis, by cryo-electron microscopy and single-particle reconstruction, of the structure of the 80S ribosome from Trypanosoma cruzi, the kinetoplastid protozoan pathogen that causes Chagas disease. The density map of the T. cruzi 80S ribosome shows the phylogenetically conserved eukaryotic rRNA core structure, together with distinctive structural features in both the small and large subunits. Remarkably, a previously undescribed helical structure appears in the small subunit in the vicinity of the mRNA exit channel. We propose that this rRNA structure likely participates in the recruitment of ribosome onto the 5′ end of mRNA, in facilitating and modulating the initiation of translation that is unique to the trypanosomes. © 2005 by The National Academy of Sciences of the USA.

Registro:

Documento: Artículo
Título:The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components
Autor:Gao, H.; Ayub, M.J.; Levin, M.J.; Frank, J.
Filiación:Howard Hughes Medical Institute, Health Research, Inc., Wadsworth Center, Empire State Plaza, Albany, NY 12201-0509, United States
Department of Biomedical Sciences, State University of New York, Empire State Plaza, Albany, NY 12201-0509, United States
Laboratory of Molecular Biology of Chagas Disease (LaBMECh), Instituto de Ingenieria Genetica y Biologia Molecular, National Research Council (CONICET), 1428 Buenos Aires, Argentina
Palabras clave:Eukaryote; Initiation; Translation; messenger RNA; ribosome RNA; 80s ribosome subunit; article; Chagas disease; cryoelectron microscopy; eukaryote; genetic conservation; nonhuman; priority journal; ribosome subunit; RNA structure; RNA translation; structure analysis; translation initiation; Trypanosoma cruzi; Animals; Base Pairing; Cryoelectron Microscopy; Image Processing, Computer-Assisted; Models, Molecular; Ribosomes; RNA, Ribosomal; Trypanosoma cruzi; Eukaryota; Kinetoplastida; Protozoa; Trypanosoma cruzi
Año:2005
Volumen:102
Número:29
Página de inicio:10206
Página de fin:10211
DOI: http://dx.doi.org/10.1073/pnas.0500926102
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
CAS:RNA, Ribosomal
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v102_n29_p10206_Gao

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Citas:

---------- APA ----------
Gao, H., Ayub, M.J., Levin, M.J. & Frank, J. (2005) . The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components. Proceedings of the National Academy of Sciences of the United States of America, 102(29), 10206-10211.
http://dx.doi.org/10.1073/pnas.0500926102
---------- CHICAGO ----------
Gao, H., Ayub, M.J., Levin, M.J., Frank, J. "The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components" . Proceedings of the National Academy of Sciences of the United States of America 102, no. 29 (2005) : 10206-10211.
http://dx.doi.org/10.1073/pnas.0500926102
---------- MLA ----------
Gao, H., Ayub, M.J., Levin, M.J., Frank, J. "The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components" . Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 29, 2005, pp. 10206-10211.
http://dx.doi.org/10.1073/pnas.0500926102
---------- VANCOUVER ----------
Gao, H., Ayub, M.J., Levin, M.J., Frank, J. The structure of the 80S ribosome from Trypanosoma cruzi reveals unique rRNA components. Proc. Natl. Acad. Sci. U. S. A. 2005;102(29):10206-10211.
http://dx.doi.org/10.1073/pnas.0500926102