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Refojo, D.; Echenique, C.; Müller, M.B.; Reul, J.M.H.M.; Deussing, J.M.; Wurst, W.; Sillaber, I.; Paez-Pereda, M.; Holsboer, F.; Arzt, E. "Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas" (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(17):6183-6188
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Abstract:

Corticotropin-releasing hormone (CRH) coordinates hormonal and behavioral responses to stress. The mitogen-activated protein kinase extracellular signal-related kinase 1/2 (ERK1/2) mediates several functions in different forebrain structures and recently has been implicated in CRH signaling in cultured cells. To study in vivo CRH-mediated activation of central ERK1/2, we investigated the expression pattern of the phosphorylated ERK1/2 (p-ERK1/2) in the mouse brain after intracerebroventricular CRH injections. As shown by immunohistochemistry and confocal microscopy analysis, CRH administration increased p-ERK1/2 levels specifically in the CA3 and CA1 hippocampal subfields and basolateral complex of the amygdala, both structures related to external environmental information processing and behavioral aspects of stress. Other regions such as hypothalamic nuclei and the central nucleus of the amygdala, also related to central CRH system but involved in the processing of the ascending visceral information and neuroendocrine-autonomic response to stress, did not show CRH-mediated ERK1/2 activation. To dissect the involvement of CRH receptor 1 (CRHR1) and CRHR2, we used conditional knockout mice in which Crhr1 is inactivated in the anterior forebrain and limbic structures. The conditional genetic ablation of Crhr1 inhibited the p-ERK1/2 increase, underlining the involvement of CRHR1 in the CRH-mediated activation. These findings underscore the fact that CRH activates p-ERK1/2 through CRHR1 only in selected brain regions, pointing to a specific role of this pathway in mediating behavioral adaptation to stress. © 2005 by The National Academy of Sciences of the USA.

Registro:

Documento: Artículo
Título:Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas
Autor:Refojo, D.; Echenique, C.; Müller, M.B.; Reul, J.M.H.M.; Deussing, J.M.; Wurst, W.; Sillaber, I.; Paez-Pereda, M.; Holsboer, F.; Arzt, E.
Filiación:Depto. Fisiol. y Biol. Molec. y Cel., Fac. de Ciencias Exactes y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Inst. Fisiol., Biol. Molec./N., Lab. de Fisiol. y Biologia Molecular, Consejo Nac. de Invest. Cie. y Tec., 1428 Buenos Aires, Argentina
Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany
Affectis Pharmaceutical, Kraepelinstrasse 2, 80804 Munich, Germany
Lab. de Fisiol. y Biologia Molecular, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Corticotropin-releasing hormone receptor 1 conditional knockout; Extracellular signal-regulated kinase 1/2; Mitogen-activated protein kinase; corticotropin releasing factor; corticotropin releasing factor receptor 1; corticotropin releasing factor receptor 2; mitogen activated protein kinase 1; mitogen activated protein kinase 3; adaptation; amygdaloid nucleus; animal experiment; animal tissue; article; brain; brain region; confocal microscopy; controlled study; crhr1 gene; enzyme activation; forebrain; gene; gene inactivation; hippocampus; hormone action; hypothalamus; immunohistochemistry; knockout mouse; limbic cortex; male; mouse; nonhuman; priority journal; protein expression; stress; Animals; Brain; Corticotropin-Releasing Hormone; Enzyme Activation; Hypothalamus; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Organ Specificity; Prosencephalon
Año:2005
Volumen:102
Número:17
Página de inicio:6183
Página de fin:6188
DOI: http://dx.doi.org/10.1073/pnas.0502070102
Título revista:Proceedings of the National Academy of Sciences of the United States of America
Título revista abreviado:Proc. Natl. Acad. Sci. U. S. A.
ISSN:00278424
CODEN:PNASA
CAS:corticotropin releasing factor, 9015-71-8; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; Corticotropin-Releasing Hormone, 9015-71-8; Mitogen-Activated Protein Kinase 3, EC 2.7.1.37; Mitogen-Activated Protein Kinase Kinases, EC 2.7.1.-
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v102_n17_p6183_Refojo

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Citas:

---------- APA ----------
Refojo, D., Echenique, C., Müller, M.B., Reul, J.M.H.M., Deussing, J.M., Wurst, W., Sillaber, I.,..., Arzt, E. (2005) . Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proceedings of the National Academy of Sciences of the United States of America, 102(17), 6183-6188.
http://dx.doi.org/10.1073/pnas.0502070102
---------- CHICAGO ----------
Refojo, D., Echenique, C., Müller, M.B., Reul, J.M.H.M., Deussing, J.M., Wurst, W., et al. "Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas" . Proceedings of the National Academy of Sciences of the United States of America 102, no. 17 (2005) : 6183-6188.
http://dx.doi.org/10.1073/pnas.0502070102
---------- MLA ----------
Refojo, D., Echenique, C., Müller, M.B., Reul, J.M.H.M., Deussing, J.M., Wurst, W., et al. "Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas" . Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 17, 2005, pp. 6183-6188.
http://dx.doi.org/10.1073/pnas.0502070102
---------- VANCOUVER ----------
Refojo, D., Echenique, C., Müller, M.B., Reul, J.M.H.M., Deussing, J.M., Wurst, W., et al. Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proc. Natl. Acad. Sci. U. S. A. 2005;102(17):6183-6188.
http://dx.doi.org/10.1073/pnas.0502070102