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Abstract:

A dispersive liquid-liquid micro extraction (DLLME) liquid chromatographic method that allows extraction and separation of gliclazide, glibenclamide and glimepiride from serum was developed and optimized with the use of experimental design. The analyzed factors in optimization were type of extracting solvent, extracting solvent volume, dispersing solvent volume, pH and protein precipitation. The selected conditions for DLLME were dichloromethane 100 μL (extracting solvent), acetonitrile 1000 μL (dispersing solvent) and no protein precipitation. This procedure is simple, requires no sophisticated procedures and produces excellent analyte recoveries. Quantitation of glibenclamide, gliclazide and glimepiride in serum samples was carried out by HPLC. This analytical method has been developed and validated, allowing quantitation of the target analytes in presence of atenolol, enalapril and amlodipine besides other serum sample interferents. The chromatographic method is linear, accurate, precise and specific and has the ability to separate the antihyperglycemic drugs from antihypertensive drugs, which are usually found in serum of diabetic patients (LOQs ca. 0.12 μg L-1 for the three analytes). © 2016 Elsevier B.V..

Registro:

Documento: Artículo
Título:Chemometric optimization and validation of a novel dispersive liquid-liquid microextraction-HPLC method for gliclazide, glibenclamide and glimepiride quantitation in serum samples
Autor:Monzón, C.M.; Teglia, C.M.; Delfino, M.R.; Goicoechea, H.C.
Filiación:Laboratorio de Química Analítica Instrumental, Facultad de Ciencias Exactas Naturales y Agrimensura (FaCENA), Universidad Nacional del Nordeste (UNNE), Corrientes, Argentina
Laboratorio de Desarrollo Analítico y Quimiometría (LADAQ), Cátedra de Química Analítica I, Facultad de Bioquimica y Ciencias Biológicas (FBCB) Universidad Nacional del Litoral (UNL), C.C. 242, Santa Fe, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Palabras clave:Chemometrics; DLLME; Glibenclamide; Gliclazide; Glimepiride; HPLC
Año:2016
Volumen:127
Página de inicio:113
Página de fin:119
DOI: http://dx.doi.org/10.1016/j.microc.2016.02.011
Título revista:Microchemical Journal
Título revista abreviado:Microchem. J.
ISSN:0026265X
CODEN:MICJA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0026265X_v127_n_p113_Monzon

Referencias:

  • (2006) International Diabetes Federation (WHO/IDF) "Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia": report of a WHO/IDF consultation, , World Health Organization, Geneva
  • Segunda Encuesta Nacional de Factores de Riesgo para Enfermedades No Transmisibles (2011) B. Aires
  • (2011) Clinical Guideline 87: "Type 2 Diabetes. The Management of Type 2 Diabetes". London
  • Gress, T.W., Nieto, F.J., Shahar, E., Wofford, M.R., Brancati, F.L., Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study (2000) J. Med., 342, pp. 905-912
  • DeRuiter, J., (2003) Endocrine Pharmacotherapy Module Overview of the antidiabetic agents
  • AbuRuz, S., Millership, J., McElnay, J., The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma (2005) J. Chromatogr. B, 817, pp. 277-286
  • Khatri, J., Qassim, S., Abed, O., Abraham, B., A novel extractionlesshplc fluorescence method for the determination of glyburide in the human plasma: application to a bioequivalence study (2001) J. Pharm. Pharm. Sci., 4, pp. 201-206
  • Yusuf, A., Hammami, M., Validation of a new high performance liquid chromatography assay for glibenclamide in human plasma (2009) J. Pharm. Sci., 34, pp. 119-125
  • Tanabe, S., Kobayashi, T., Kawanab, K., Determination of oral hypoglycemic biguanides by high performance liquid chromatography with fluorescence detection (1987) Anal. Sci., 3, pp. 69-73
  • Lai, E.P.C., Feng, S.Y., Solid phase extraction-non-aqueous capillary electrophoresis for determination of metformin, phenformin and glyburide in human plasma (2006) J. Chromatogr. B, 843, pp. 94-99
  • Georgita, C., Albu, F., David, V., Medvedovici, A., Simultaneous assay of metformin and glibenclamide in human plasma based on extraction-less sample preparation procedure and LC/(APCI)MS (2007) J. Chromatogr. B, 854, pp. 211-218
  • Feng, S.Y., Lai, E.P.C., Dabek-Zlotorzynska, E., Sadeghi, S., Molecularly imprinted solid-phase extraction for the screening of antihyperglycemicbiguanides (2004) J. Chromatogr. A, 1027, pp. 155-160
  • Hoa, E., Yiua, K., Wana, T., Stewartb, B., Watkinsb, K., Detection of anti-diabetics in equine plasma and urine by liquid chromatography-tandem mass spectrometry (2004) J. Chromatogr. B, 811, pp. 65-73
  • Magni, F., Marazzini, L., Pereira, S., Monti, L., GalliKienle, M., Identification of sulfonylureas in serum by electrospray mass spectrometry (2000) Anal. Biochem., 282, pp. 136-141
  • Maurer, H.H., Kratzsch, C., Kraemer, T., Peters, F.T., Weber, A.A., Screening, library-assisted identification and validated quantification of oral antidiabetics of the sulfonylurea-type in plasma by atmospheric pressure chemical ionization liquid chromatography-mass spectrometry (2002) J. Chromatogr. B, 773, pp. 63-73
  • Niopas, I., Daftsios, A.C., A validated high-performance liquid chromatographic method for the determination of glibenclamide in human plasma and its application to pharmacokinetic studies (2002) J. Pharm. Biomed., 28, pp. 653-657
  • VenkataRayanm, I., LakshmanRao, A., Ramana, M.V., Validated RP-HPLC method for the estimation of glibenclamide in formulation and serum (2011) J. Pharm. Biomed. Sci., 2, pp. 856-862
  • Rezaee, M., Assadi, Y., MilaniHosseini, M.R., Aghaee, E., Ahmadi, F., Berijani, S., Determination of organic compounds in water using dispersive liquid-liquid microextraction (2006) J. Chromatogr. A, 1116, pp. 1-9
  • Myers, R.H., Montgomery, D., Anderson-Cook, C.M., (2009) Response Surface Methodology: Process and Product Optimization Using Designed Experiments, , Wiley, New Jersey
  • Wang, S.C., Liao, H.J., Lee, W.C., Huang, C.M., Tsai, T.H., Using orthogonal array to obtain gradient liquid chromatography conditions of enhanced peak intensity to determine geniposide and genipin with electrospray tandem mass spectrometry (2008) J. Chromatogr. A, 1212, pp. 68-75
  • Zhou, Y., Song, J.Z., Choi, F.F.K., Wu, H.F., Qiao, C.F., Ding, L.S., Gesang, S.L., Xu, H.X., An experimental design approach using response surface techniques to obtain optimal liquid chromatography and mass spectrometry conditions to determine the alkaloids in Meconopsi species (2009) J. Chromatogr. A, 1216, pp. 7013-7023
  • Andrade-Eiroa, A., Diévart, P., Dagaut, P., Improved optimization of polycyclic aromatic hydrocarbons (PAHs) mixtures resolution in reversed-phase high-performance liquid chromatography by using factorial design and response surface methodology (2010) Talanta, 81, pp. 265-274
  • Iuliani, P., Carlucci, G., Marrone, A., Investigation of the HPLC response of NSAIDs by fractional experimental design and multivariate regression analysis. Response optimization and new retention parameters (2010) J. Pharm. Biomed., 51, pp. 46-55
  • Fourdinier, M., Bostyn, S., Delépée, R., Fauduet, H., Interest of a chemometric approach in understanding the retention behaviour of three columns in hydrophilic interaction liquid chromatography: application to the separation of glycerol carbonate, glycerol and urea (2010) Talanta, 81, pp. 1281-1287
  • Gil García, M.D., CañadaCañada, F., Culzoni, M.J., Vera-Candioti, L., Siano, G.G., Goicoechea, H.C., MartínezGalera, M., Chemometric tools improving the determination of anti-inflammatory and antiepileptic drugs in river and wastewater by solid-phase microextraction and liquid chromatography diode array detection (2009) J. Chromatogr. A, 1216, pp. 5489-5496
  • Moreira, N., Meireles, S., Brandão, T., Guedes de Pinho, P., Optimization of the HS-SPME-GC IT/MS method using a central composite design for volatile carbonyl compounds determination in beers (2013) Talanta, 117, pp. 523-531
  • Almeida Bezerra, M., ErthalSantelli, R., Padua Oliveira, E., SilveiraVillar, L., Escaleira, L.A., Response surface methodology (RSM) as a tool for optimization in analytical chemistry (2008) Talanta, 76, p. 965
  • Vera-Candioti, L., Cámara, M., De Zan, M.M., Goicoechea, H., Multiple response optimization applied to the development of a capillary electrophoretic method for pharmaceutical analysis (2014) Talanta, 124, pp. 123-138
  • Tarazona, I., Chisvert, A., Salvador, A., Determination of benzophenone-3 and its main metabolites in human serum by dispersive liquid-liquid microextraction followed by liquid chromatography tandem mass spectrometry (2013) Talanta, 116, pp. 388-395
  • (2012) Committee for Medicinal Products for Human Use (CHMP)
  • Gałuszka, A., Migaszewski, Z., Namiesnik, J., The 12 principles of green analytical chemistry and the SIGNIFICANCE mnemonic of green analytical practices (2013) Trends Anal. Chem., 50, pp. 78-84
  • Olivieri, A.C., Practical guidelines for reporting results in single- and multi-component analytical calibration: a tutorial (2015) Anal. Chim. Acta, 868, pp. 10-22
  • Yao, J., Shi, Y.Q., Li, Z.R., Jin, S.H., Development of a RP-HPLC method for screening potentially counterfeit anti-diabetic drugs (2007) J. Chromatogr. B, 853, pp. 254-259
  • Arayne, M.S., Sultana, N., Tabassuma, A., RP-LC simultaneous quantitation of co-administered drugs for (non-insulin dependent) diabetic mellitus induced dyslipidemia in active pharmaceutical ingredient, pharmaceutical formulations and human serum with UV-detector (2013) Clin. Chim. Acta, 425, pp. 54-61
  • Polagani, S.R., Pilli, N.R., Gajulab, R., Ganduc, V., Simultaneous determination of atorvastatin, metformin and glimepiride in human plasma by LC-MS/MS and its application to a human pharmacokinetic study (2013) J. Pharm. Anal., 3, pp. 9-19
  • de Oliveira Viana, I.M., Lima, P.R., Duarte ViannaSoares, C., Fernandes, C., Simultaneous determination of oral antidiabetic drugs in human plasma using microextraction by packed sorbent and high-performance liquid chromatography (2014) J. Pharm. Biomed., 96, pp. 241-248

Citas:

---------- APA ----------
Monzón, C.M., Teglia, C.M., Delfino, M.R. & Goicoechea, H.C. (2016) . Chemometric optimization and validation of a novel dispersive liquid-liquid microextraction-HPLC method for gliclazide, glibenclamide and glimepiride quantitation in serum samples. Microchemical Journal, 127, 113-119.
http://dx.doi.org/10.1016/j.microc.2016.02.011
---------- CHICAGO ----------
Monzón, C.M., Teglia, C.M., Delfino, M.R., Goicoechea, H.C. "Chemometric optimization and validation of a novel dispersive liquid-liquid microextraction-HPLC method for gliclazide, glibenclamide and glimepiride quantitation in serum samples" . Microchemical Journal 127 (2016) : 113-119.
http://dx.doi.org/10.1016/j.microc.2016.02.011
---------- MLA ----------
Monzón, C.M., Teglia, C.M., Delfino, M.R., Goicoechea, H.C. "Chemometric optimization and validation of a novel dispersive liquid-liquid microextraction-HPLC method for gliclazide, glibenclamide and glimepiride quantitation in serum samples" . Microchemical Journal, vol. 127, 2016, pp. 113-119.
http://dx.doi.org/10.1016/j.microc.2016.02.011
---------- VANCOUVER ----------
Monzón, C.M., Teglia, C.M., Delfino, M.R., Goicoechea, H.C. Chemometric optimization and validation of a novel dispersive liquid-liquid microextraction-HPLC method for gliclazide, glibenclamide and glimepiride quantitation in serum samples. Microchem. J. 2016;127:113-119.
http://dx.doi.org/10.1016/j.microc.2016.02.011