Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor

Abstract:

Trypanosoma cruzi is the etiological agent of Chagas disease, a disease endemic not only in Argentina but also in all of Latinamerica. T. cruzi presents several metabolic characteristics which are completely absent in its insect vectors and in mammalian hosts. Some of these differences were acquired after millions of years of adaptation to parasitism, during which this protozoan replaced many biosynthetic routes for transport systems. In the present review, we describe the advances in the knowledge of T. cruzi transport processes and the molecules involved. In particular, we focus on aminoacid and polyamine transporters from the AAAP family (Amino Acid/Auxin Permeases), because they seem to be exclusive transporters from trypanosomatids. Taking into account that these permeases are completely absent in mammals, they could be considered as a potential target against Trypanosoma cruzi.

Registro:

Documento: Artículo
Título:Trypanosoma cruzi: Transport of essential metabolites acquired from the host
Autor:Pereira, C.A.; Carrillo, C.; Miranda, M.R.; Bouvier, L.A.; Canepa, G.E.
Filiación:Laboratorio de Biología Molecular de Trypanosoma Cruzi, Instituto de Investigaciones Médicas Alfredo P. Lanari, Universidad de Buenos Aires, Combatientes de Malvinas 3150, 1427 Buenos Aires, Argentina
Fundación Instituto Leloir, Departamento de Quimíca Biológica, Universidad de Buenos Aires, Combatientes de Malvinas 3150, 1427 Buenos Aires, Argentina
Palabras clave:Aminoacids; Chagas disease; Permeases; Polyamines; Transporters; Trypanosoma cruzi; amino acid transporter; polyamine; article; Chagas disease; drug targeting; host parasite interaction; human; metabolite; nonhuman; parasite transmission; protein analysis; protein targeting; Trypanosoma; Trypanosoma cruzi; Amino Acids; Animals; Argentina; Biological Transport; Chagas Disease; Host-Parasite Interactions; Humans; Polyamines; Protozoan Proteins; Trypanosoma cruzi
Año:2008
Volumen:68
Número:5
Página de inicio:398
Página de fin:404
Título revista:Medicina
Título revista abreviado:Medicina (Argentina)
ISSN:00257680
CODEN:MEDCA
CAS:Amino Acids; Polyamines; Protozoan Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira

Referencias:

  • Tropical disease research: progress 1999-2000, http://www.who.int/tdr; Steindel, M., Kramer Pacheco, L., Scholl, D., Characterization of Trypanosoma cruzi isolated from humans, vectors, and animal reservoirs following an outbreak of acute human Chagas disease in Santa Catarina State, Brazil (2008) Diagn Microbiol Infect Dis, 60, pp. 25-32
  • Reddy, M., Gill, S.S., Kalkar, S.R., Wu, W., Anderson, P.J., Rochon, P.A., Oral drug therapy for multiple neglected tropical diseases: A systematic review (2007) JAMA, 298, pp. 1911-1924
  • Barrett, M.P., Burchmore, R.J., Stich, A., The trypanosomiases (2003) Lancet, 362, pp. 1469-1480
  • Jackson, A.P., Origins of amino acid transporter loci in Trypanosomatid parasites (2007) BMC Evol Biol, 7, p. 26
  • Briones, M.R., Souto, R.P., Stolf, B.S., Zingales, B., The evolution of two Trypanosoma cruzi subgroups inferred from rRNA genes can be correlated with the interchange of American mammalian faunas in the Cenozoic and has implications to pathogenicity and host specificity (1999) Mol Biochem Parasitol, 104, pp. 219-232
  • Ghedin, E., Bringaud, F., Peterson, J., Gene synteny and evolution of genome architecture in Trypanosomatids (2004) Mol Biochem Parasitol, 134, pp. 183-191
  • Vazquez, M.P., The genetics and genomics of Trypanosoma cruzi (2007) Int J Biomed Pharm Sci, 1, pp. 1-11
  • Chagas C. Nova tripanozomiase humana: Estudos sobre a morfología e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., agente etiológico de nova entidade morbida do homem. Mem Inst Oswaldo Cruz 1909; 1: 159-218; Romaña, C., (1963) Enfermedad de Chagas, , Lopez Libreros Ed, Buenos Aires
  • Tyler, K.M., Engman, D.M., The life cycle of Trypanosoma cruzi revisited (2001) Int J Parasitol, 31, pp. 472-481
  • Bellofatto, V., Pyrimidine transport activities in trypanosomes (2007) Trends Parasitol, 23, pp. 187-189
  • Landfear, S.M., Molecular genetics of nucleoside transporters in Leishmania and African trypanosomes (2001) Biochem Pharmacol, 62, pp. 149-155
  • Maser, P., Sutterlin, C., Kralli, A., Kaminsky, R., A nucleoside transporter from Trypanosoma brucei involved in drug resistance (1999) Science, 285, pp. 242-244
  • Barrett, M.P., Gilbert, I.H., Targeting of toxic compounds to the trypanosome's interior (2006) Adv Parasitol, 63, pp. 125-183
  • Cazzulo, J.J., Intermediate metabolism in Trypanosoma cruzi (1994) J Bioenerg Biomembr, 2, pp. 157-165
  • Tetaud, E., Barrett, M.P., Bringaud, F., Baltz, T., Kinetoplastid glucose transporters (1997) Biochem J, 325, pp. 569-580
  • Tetaud, E., Bringaud, F., Chabas, S., Barrett, M.P., Baltz, T., Characterization of glucose transport and cloning of a hexose transporter gene in Trypanosoma cruzi (1994) Proc Natl Acad Sci USA, 91, pp. 8278-8282
  • Barrett, M.P., Tetaud, E., Seyfang, A., Bringaud, F., Baltz, T., Trypanosome glucose transporters (1998) Mol Biochem Parasitol, 91, pp. 195-205
  • Bringaud, F., Riviere, L., Coustou, V., Energy metabolism of Trypanosomatids: Adaptation to available carbon sources (2006) Mol Biochem Parasitol, 149, pp. 1-9
  • Zeledon, R., Comparative physiological studies on four species of hemoflagellates in culture. II. Effect of carbohydrates and related substances and some amino compounds on the respiration (1960) J Parasitol, 46, pp. 541-551
  • Berriman, M., Ghedin, E., Hertz-Fowler, C., The genome of the African trypanosome Trypanosoma brucei (2005) Science, 309, pp. 416-422
  • Contreras, V.T., Salles, J.M., Thomas, N., Morel, C.M., Goldenberg, S., In vitro differentiation of Trypanosoma cruzi under chemically defined conditions (1985) Mol Biochem Parasitol, 3, pp. 315-327
  • Canepa, G.E., Bouvier, L.A., Urias, U., Aspartate transport and metabolism in the protozoan parasite Trypanosoma cruzi (2005) FEMS Microbiol Lett, 247, pp. 65-71
  • Tonelli, R.R., Silber, A.M., Almeida-de-Faria, M., Hirata, I.Y., Colli, W., Alves, M.J., L-proline is essential for the intracellular differentiation of Trypanosoma cruzi (2004) Cell Microbiol, 8, pp. 733-741
  • Nozaki, T., Ali, V., Tokoro, M., Sulfur-containing amino acid metabolism in parasitic protozoa (2005) Adv Parasitol, 60, pp. 1-99
  • Krauth-Siegel, R.L., Meiering, S.K., Schmidt, H., The parasite-specific trypanothione metabolism of Trypanosoma and Leishmania (2003) Biol Chem, 384, pp. 539-549
  • Pereira, C.A., Alonso, G.D., Torres, H.N., Flawia, M.M., Arginine kinase: A common feature for management of energy reserves in African and American flagellated Trypanosomatids (2002) J Eukaryot Microbiol, 49, pp. 82-85
  • Pereira, C.A., Alonso, G.D., Paveto, M.C., Flawia, M.M., Torres, H.N., L-arginine uptake and L-phosphoarginine synthesis in Trypanosoma cruzi (1999) J Eukaryot Microbiol, 46, pp. 566-570
  • Pereira, C.A., Alonso, G.D., Paveto, M.C., Trypanosoma cruzi arginine kinase characterization and cloning. A novel energetic pathway in protozoan parasites (2000) J Biol Chem, 275, pp. 1495-1501
  • Canepa, G.E., Silber, A.M., Bouvier, L.A., Pereira, C.A., Biochemical characterization of a low-affinity arginine permease from the parasite Trypanosoma cruzi (2004) FEMS Microbiol Lett, 236, pp. 79-84
  • Gonzalez, N.S., Ceriani, C., Algranati, I.D., Differential regulation of putrescine uptake in Trypanosoma cruzi and other Trypanosomatids (1992) Biochem Biophys Res Commun, 188, pp. 120-128
  • Le Quesne, S.A., Fairlamb, A.H., Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes (1996) Biochem J, 316, pp. 481-486
  • Carrillo, C., Cejas, S., Gonzalez, N.S., Algranati, I.D., Trypanosoma cruzi epimastigotes lack ornithine decarboxylase but can express a foreign gene encoding this enzyme (1999) FEBS Lett, 454, pp. 192-196
  • Carrillo, C., Cejas, S., Huber, A., Gonzalez, N.S., Algranati, I.D., Lack of arginine decarboxylase in Trypanosoma cruzi epimastigotes (2003) J Eukaryot Microbiol, 50, pp. 312-316
  • Hasne, M.P., Ullman, B., Identification and characterzation of a polyamine permease from the protozoan parasite Leishmania major (2005) J Biol Chem, 280, pp. 15188-15194
  • Carrillo, C., Canepa, G.E., Algranati, I.D., Pereira, C.A., Molecular and functional characterization of a spermidine transporter (TcPAT12) from Trypanosoma cruzi (2006) Biochem Biophys Res Commun, 344, pp. 936-940
  • Silber, A.M., Rojas, R.L., Urias, U., Colli, W., Alves, M.J., Biochemical characterization of the glutamate transport in Trypanosoma cruzi (2006) Int J Parasitol, 36, pp. 157-163
  • Young, G.B., Jack, D.L., Smith, D.W., Saier Jr., M.H., The amino acid/auxin:proton symport permease family (1999) Biochim Biophys Acta, 1415, pp. 306-322
  • Bouvier, L.A., Silber, A.M., Galvao Lopes, C., Post genomic analysis of permeases from the amino acid/auxin family in protozoan parasites (2004) Biochem Biophys Res Commun, 321, pp. 547-556
  • Geraldo, M.V., Silber, A.M., Pereira, C.A., Uliana, S.R., Characterization of a developmentally regulated amino acid transporter gene from Leishmania amazonensis (2005) FEMS Microbiol Lett, 242, pp. 275-280
  • El-Sayed, N.M., Myler, P.J., Blandin, G., The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease (2005) Science, 309, pp. 409-415
  • Ivens, A.C., Peacock, C.S., Worthey, E.A., The genome of the kinetoplastid parasite, Leishmania major (2005) Science, 309, pp. 436-442
  • Pinney, J.W., Papp, B., Hyland, C., Wambua, L., Westhead, D.R., McConkey, G.A., Metabolic reconstruction and analysis for parasite genomes (2007) Trends Parasitol, 23, pp. 548-554

Citas:

---------- APA ----------
Pereira, C.A., Carrillo, C., Miranda, M.R., Bouvier, L.A. & Canepa, G.E. (2008) . Trypanosoma cruzi: Transport of essential metabolites acquired from the host . Medicina, 68(5), 398-404.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira [ ]
---------- CHICAGO ----------
Pereira, C.A., Carrillo, C., Miranda, M.R., Bouvier, L.A., Canepa, G.E. "Trypanosoma cruzi: Transport of essential metabolites acquired from the host " . Medicina 68, no. 5 (2008) : 398-404.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira [ ]
---------- MLA ----------
Pereira, C.A., Carrillo, C., Miranda, M.R., Bouvier, L.A., Canepa, G.E. "Trypanosoma cruzi: Transport of essential metabolites acquired from the host " . Medicina, vol. 68, no. 5, 2008, pp. 398-404.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira [ ]
---------- VANCOUVER ----------
Pereira, C.A., Carrillo, C., Miranda, M.R., Bouvier, L.A., Canepa, G.E. Trypanosoma cruzi: Transport of essential metabolites acquired from the host . Medicina (Argentina). 2008;68(5):398-404.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira [ ]