Artículo
Wider, E.A.; Ferranti, D.; Mozzarelli, M.N.; Giancarlo, H.; Della Valle, M.G.; Cimmino, V.; Movia, R. "Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients " (1997) Medicina. 57(3):275-280
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Abstract:
Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy.
Registro:
| Documento: | Artículo |
| Título: | Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients |
| Autor: | Wider, E.A.; Ferranti, D.; Mozzarelli, M.N.; Giancarlo, H.; Della Valle, M.G.; Cimmino, V.; Movia, R. |
| Filiación: | Depto. de Quimica Biológica, Facuitad de Cie. Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina Departamento de Medicina, Hosp. Gen. Agudos Dr. Cosme Argerich, Buenos Aires, Argentina Departamento de Quimica Biologica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, 1424 Buenos Aires, Argentina |
| Palabras clave: | porphobilinogen synthase; adult; aged; alcoholism; article; female; human; male; metabolism; middle aged; Adult; Aged; Alcoholism; Female; Humans; Male; Middle Aged; Porphobilinogen Synthase |
| Año: | 1997 |
| Volumen: | 57 |
| Número: | 3 |
| Página de inicio: | 275 |
| Página de fin: | 280 |
| Título revista: | Medicina |
| Título revista abreviado: | Medicina (Argentina) |
| ISSN: | 00257680 |
| CODEN: | MEDCA |
| CAS: | Porphobilinogen Synthase, EC 4.2.1.24 |
| PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_00257680_v57_n3_p275_Wider.pdf |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider |
Referencias:
- Ohnishi, K., Lieber, C.S., Reconstitution of the microsomal ethanol-oxidizing system (1977) J Biol Chem, 252, pp. 7124-7128
- Pritchard, P.H., Bowley, M., Burditt, S.L., Cooling, J., Glenny, H., Lawson, N., The effects of acute ethanol feeding and chronic benfluorex administration in the activities of some enzymes of glycerol synthesis in rat liver and adipose tissue (1977) Biochem J, 66, pp. 639-642
- Mauzerall, D., Granick, S., The occurrence and determination of aminolevulinic acid and porphobilinogen in urine (1956) J Biol Chem, 219, pp. 435-445
- Rimington, C., Quantitative determination of porphobilinogen and porphirins in urine and feces (1961) Ass Clin Broat Sheet, 36, pp. 1-7
- With, T.K., Clinical use of porphyrin ester chromatography of urine and feces (1975) Danish Med Bull, 22, pp. 80-86
- Shoua, A.E.M., Batlle, A.M.D.C., Indice de porfirinas plasmáticas (1987) Rev Arg Dermatol, 68, pp. 79-85
- Bustos, N., Stella, A.M., Wider, E.A., Batlle, A.M., Studies on erythrocyte aminolaevulinate dehydratase. I. Its purification and possible therapeutic applications (1980) Int J Biochem, 12, pp. 745-749
- Batlle, A.M.D.C., Wider, E.A., Stella, A.M., A simple method for measuring erythrocyte porphobilinogenase and its use in the diagnosis of acute intermittent porphyria (1978) Int J Biochem, 9, pp. 871-876
- Ostrowski, J., Kosecki, P., Milewski, B., Urinary porphyrins in liver disease (1984) Scand J Gastroenterol, 19, pp. 862-866
- Lindblad, R., Lindstedt, S., Steen, G., On the enzymic defects in hereditary tyrosinemia (1977) Proc Natl Acad Si, 74, pp. 4641-4645
- Dagg, J., Goldberg, A., Lockhead, A., Smith, J.A.Q., The relationship of lead poisoning to acute intermittent porphyria (1964) J Med, 34, pp. 163-168
- Doss, M., Von Tiepermann, R., Schneider, Shmidtt, J., New type of hepatic porphyria with porphobilinogen synthase defect and intermittent acute clinical manifestation (1979) Klin Wschr, 5, pp. 1123-1127
- Mc Coll, K., Moore, M., Thompson, G., Goldberg, A., Abnormal haem biosynthesis in chronic alcoholics (1981) Europ J Clin Invest, 11, pp. 461-467
- Sieg, I., Doss, M., Kandels, H., Schneider, J., Effect of alcohol on delta-aminolevulinic acid dehydratase and porphyrin metabolism in man (1991) Clin Chim Acta, 202, pp. 211-218
- Cavana, J.B., Mellick, R.S., On the nature of peripheral nerve lesions associated with acute intermittent porphyria (1965) J Neurol Neurosurg Psychiatry, 28, pp. 320-326
- Willer, J.C., Dehen, H.J., Respective importance of different electrophysiological parameters in alcoholic neuropathy (1977) Neurol Sci, 33, pp. 387-396
- D'Amour, M.L., Shahani, B.T., Young, R.R., The importance of studying sural nerve conduction and late responses in the evaluations of alcoholic subjects (1979) Neurology, 29, pp. 1600-1604
- Flugel, K.A., Druschky, K.F.J., Electromyogram and nerve conduction in patients with acute intermittent porphyria (1977) Neurology, 27, p. 267
- Albers, J.W., Robertson, J.W., Daube, J.R., Electrodiagnostic finding in acute porphyric neuropathy (1978) Muscle and Nerve, 1, p. 292
- Mustajoki, P., Steppalainen, S., Neurophathy in latent hereditary hepatic porphyria (1975) Br Med J, 2, pp. 310-315
- Batlle, A.M.D.C., Parera, V.E., Stella, A.M., Wider, E., Navarret, E., Cotone, V., Senatores, V., Pagano, T., Porfiria aguda intermitente. Estudios electroneurofisiológicos y bioquimicos en una forma neurologica convulsiva (1984) Prensa Med Argent, 71, pp. 299-306
Citas:
---------- APA ----------
Wider, E.A., Ferranti, D., Mozzarelli, M.N., Giancarlo, H., Della Valle, M.G., Cimmino, V. & Movia, R. (1997) . Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients . Medicina, 57(3), 275-280.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider [ ]
---------- CHICAGO ----------
Wider, E.A., Ferranti, D., Mozzarelli, M.N., Giancarlo, H., Della Valle, M.G., Cimmino, V., et al. "Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients " . Medicina 57, no. 3 (1997) : 275-280.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider [ ]
---------- MLA ----------
Wider, E.A., Ferranti, D., Mozzarelli, M.N., Giancarlo, H., Della Valle, M.G., Cimmino, V., et al. "Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients " . Medicina, vol. 57, no. 3, 1997, pp. 275-280.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider [ ]
---------- VANCOUVER ----------
Wider, E.A., Ferranti, D., Mozzarelli, M.N., Giancarlo, H., Della Valle, M.G., Cimmino, V., et al. Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients . Medicina (Argentina). 1997;57(3):275-280.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider [ ]
