Artículo
Iribarren, A.M. "Synthetic oligonucleotides and their application in gene therapy " (1995) Medicina. 55(3):263-266
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Abstract:
Synthetic oligonucleotides are useful for research in molecular biology, for clinical diagnosis and for the development of new therapeutic agents. In fact, their application to gene therapy has given rise to a new field termed antisense, enabling the synthesis of a new generation of drugs. The procedure is based on coupling an oligonucleotide with mRNA to yield the protein whose production by the host is to be prevented, and thus through diverse pathways inhibiting gene expression. In medicine, a start has been made by applying antisense techniques in human drug trials, particularly as antiviral and antileukemic agents.
Registro:
| Documento: | Artículo |
| Título: | Synthetic oligonucleotides and their application in gene therapy |
| Autor: | Iribarren, A.M. |
| Filiación: | INGEBI, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina |
| Palabras clave: | antineoplastic agent; antisense oligonucleotide; antivirus agent; oligonucleotide; antisense oligonucleotide; gene expression; gene therapy; human; short survey; animal; article; chemistry; methodology; mouse; Animals; Gene Therapy; Humans; Mice; Oligonucleotides, Antisense |
| Año: | 1995 |
| Volumen: | 55 |
| Número: | 3 |
| Página de inicio: | 263 |
| Página de fin: | 266 |
| Título revista: | Medicina |
| Título revista abreviado: | MEDICINA |
| ISSN: | 00257680 |
| CODEN: | MEDCA |
| CAS: | Oligonucleotides, Antisense |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v55_n3_p263_Iribarren |
Citas:
---------- APA ----------
(1995) . Synthetic oligonucleotides and their application in gene therapy . Medicina, 55(3), 263-266.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v55_n3_p263_Iribarren [ ]
---------- CHICAGO ----------
Iribarren, A.M. "Synthetic oligonucleotides and their application in gene therapy " . Medicina 55, no. 3 (1995) : 263-266.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v55_n3_p263_Iribarren [ ]
---------- MLA ----------
Iribarren, A.M. "Synthetic oligonucleotides and their application in gene therapy " . Medicina, vol. 55, no. 3, 1995, pp. 263-266.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v55_n3_p263_Iribarren [ ]
---------- VANCOUVER ----------
Iribarren, A.M. Synthetic oligonucleotides and their application in gene therapy . MEDICINA. 1995;55(3):263-266.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v55_n3_p263_Iribarren [ ]
