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Abstract:

Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to its rat adrenal receptors stimulates i) aldosterone production, in vivo and in vitro ii) calcium influx, which is mediated through voltage dependent- and receptor operated- calcium channels, iii) cholesterol uptake, iv) stimulation of Na+/K+-ATPase and iv) diacylglycerol production. While the last effect is mediated through ET-A receptors the others involve binding of ET-1 to ET-B receptors. Finally, ouabain potentiates the ET-1-mediated stimulation of aldosterone production, suggesting that the effect of the peptidic hormone on Na+/K+-ATPase could act as a negative feedback mechanism.

Registro:

Documento: Artículo
Título:Mechanisms of action of endothelin-i in rat adrenal
Autor:Pecci, A.; Romero, D.G.; Lantos, C.P.; Cozza, E.N.
Filiación:Depto. de Quimica Biológica, Fac. de Cie. Exactas y Naturales, Univ. de Buenos Aires and P., 1428 Buenos Aires, Argentina
Depto. de Quimica Biológica, Fac. de Cie. Exactas y Naturales, Cdad. Universitaria, Pab. II, Piso 4, 1428 Buenos Aires, Argentina
Palabras clave:Adrenal cells; Aldosterone; Endothelin-1; 1 (5 isoquinolinesulfonyl) 2 methylpiperazine; aldosterone; calcium 45; calcium channel; corticotropin; cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl); endothelin 1; endothelin A receptor; endothelin B receptor; iodine 125; ouabain; sarafotoxin S6b; adrenal cortex; adrenal gland; animal tissue; article; controlled study; negative feedback; nonhuman; rat; renin angiotensin aldosterone system; zona glomerulosa
Año:1998
Volumen:63
Número:15
Página de inicio:1315
Página de fin:1328
DOI: http://dx.doi.org/10.1016/S0024-3205(98)00395-6
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:1 (5 isoquinolinesulfonyl) 2 methylpiperazine, 84477-87-2; aldosterone, 52-39-1, 6251-69-0; calcium 45, 13966-05-7; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl), 136553-81-6; iodine 125, 14158-31-7, 22822-81-7; ouabain, 11018-89-6, 630-60-4; sarafotoxin S6b, 116303-65-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v63_n15_p1315_Pecci

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Citas:

---------- APA ----------
Pecci, A., Romero, D.G., Lantos, C.P. & Cozza, E.N. (1998) . Mechanisms of action of endothelin-i in rat adrenal. Life Sciences, 63(15), 1315-1328.
http://dx.doi.org/10.1016/S0024-3205(98)00395-6
---------- CHICAGO ----------
Pecci, A., Romero, D.G., Lantos, C.P., Cozza, E.N. "Mechanisms of action of endothelin-i in rat adrenal" . Life Sciences 63, no. 15 (1998) : 1315-1328.
http://dx.doi.org/10.1016/S0024-3205(98)00395-6
---------- MLA ----------
Pecci, A., Romero, D.G., Lantos, C.P., Cozza, E.N. "Mechanisms of action of endothelin-i in rat adrenal" . Life Sciences, vol. 63, no. 15, 1998, pp. 1315-1328.
http://dx.doi.org/10.1016/S0024-3205(98)00395-6
---------- VANCOUVER ----------
Pecci, A., Romero, D.G., Lantos, C.P., Cozza, E.N. Mechanisms of action of endothelin-i in rat adrenal. Life Sci. 1998;63(15):1315-1328.
http://dx.doi.org/10.1016/S0024-3205(98)00395-6