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Abstract:

Gamma-aminobutyric acid (GABA) is involved in the neural control of hypophyseal hormones, including PRL and TSH. In the present work we investigated the ontogeny of the effect of baclofen, a GABA B agonist, on basal PRL and TSH release and in the presence of releasing stimulus which act at two different levels: TRH, at the hypophyseal level, and serotonin, at the central nervous system. Ages studied were 4, 12, 20, 28-29, 37-38 day-old and adult male and female animals. Rats of each age and sex were separated in groups and each group received two intraperitoneally injections, one 45 minutes after the other: saline-saline, saline-TRH, baclofen-saline, baclofen-TRH, saline-serotonin or baclofen-serotonin. Rats were decapitated 15 minutes after the last injection and serum hormones were measured by RIA. Baclofen (7 mg/kg) significantly elevated basal prolactin levels at 4, 12 and 20 days of age and the stimulating effect increased with age. At 28 days of age baclofen significantly inhibited PRL whereas from 38 days of age onwards it had no effect on basal PRL levels. No sex differences were evident. Interaction of TRH (4 μg/kg) and baclofen on PRL secretion resulted in an additive effect on days 4 and 12, this effect was not observed when baclofen was administered with serotonin (10 mg/kg). In 28 day-old and older animals baclofen completely blunted the PRL releasing effect of TRH or serotonin. Again, no sex differences were observed. With regard to TSH, baclofen did not alter either basal or TRH stimulated TSH secretion regardless of sex and age. The present experiments indicate that GABA B receptors are involved in the regulation of basal and stimulated PRL secretion from die first days of life to adulthood. Receptor activation results in stimulation or inhibition of PRL release depending on the age of the animals and the site of action. This GABA B regulation of PRL secretion is sex independent. In contrast, pituitary GABA B receptors do not seem to be involved in the regulation of TSH secretion.

Registro:

Documento: Artículo
Título:In vivo interaction of baclofen, TRH and serotonin on PRL and TSH secretion in the developing and adult male and female rats
Autor:Rey-Roldán, E.B.; Lux-Lantos, V.; Chamsoti-Reig, A.; Libertun, C.
Filiación:Lab. de Neuroendocrinología, Inst. de Biología y Med. Exp., CONICET, V.de Obligado 2490, (1428) Buenos Aires, Argentina
Palabras clave:Baclofen; Prolactin; Serotonin; Thyrotropin; TRH; 4 aminobutyric acid b receptor stimulating agent; baclofen; protirelin; serotonin; animal experiment; article; controlled study; female; intraperitoneal drug administration; male; nonhuman; ontogeny; prolactin release; rat; thyrotropin release; Animals; Baclofen; Female; Male; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Serotonin; Thyrotropin; Thyrotropin-Releasing Hormone; Animalia
Año:1997
Volumen:61
Número:23
Página de inicio:2283
Página de fin:2290
DOI: http://dx.doi.org/10.1016/S0024-3205(97)00932-6
Título revista:Life Sciences
Título revista abreviado:LIFE SCI.
ISSN:00243205
CODEN:LIFSA
CAS:Baclofen, 1134-47-0; Prolactin, 9002-62-4; Receptors, GABA-B; Serotonin, 50-67-9; Thyrotropin, 9002-71-5; Thyrotropin-Releasing Hormone, 24305-27-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v61_n23_p2283_ReyRoldan

Referencias:

  • Makara, G.B., Stark, E., (1974) Neuroendocrinology, 16, pp. 178-182
  • Tanaka, E., Baba, N., Toshida, K., Suzuki, K., (1993) Life Sci., 52, pp. 669-676
  • Libertun, C., Arakelian, M.C., Larrea, G.A., Foglia, V.C., (1979) Proc Soc Exp Biol Med, 161, pp. 28-31
  • Mioduszewsky, R., Grandison, L., Meites, J., (1976) Proc Soc Exp Biol Med, 151, pp. 44-46
  • Vijayan, E., Mccann, S.M., (1978) Brain Res., 155, pp. 35-43
  • Tuomisto, J., Mannisto, P., (1985) Pharmacol. Rev., 37, p. 249
  • Fiszer De Plazas, S., Becu, D., Mitridate De Novara, A., Libertun, C., (1982) Endocrinology, 111, pp. 1974-1978
  • Demeneix, B.A., Feltz, P., Loeffler, J.P., (1986) GABAergic Mechanisms in the Mammalian Periphery, pp. 261-289. , B. Erdo S.L., N.G. (ed), Raven Press, New York
  • Anderson, R., Mitchell, R., (1986) J. Endocrinol., 108, pp. 1-8
  • Bowery, N.G., (1993) Annual Review Pharmacology and Toxicology, 33, pp. 109-147
  • Bonanno, G., Raiteri, M., (1993) Trends in Pharmacological Sciences, 14, pp. 259-261
  • Bormann, J., Feigenspan, A., (1995) Trends Neurosci., 18, pp. 515-519
  • Racagni, G., Apud, J.A., Cocchi, D., Locatelli, V., Muller, E.E., (1982) Life Sci, 31, pp. 823-838
  • Grandison, L., (1981) GABA and Benzodiacepine Receptors, pp. 219-227. , E. Costa (ed), Raven Press, New York
  • Lux, V.A.R., D'Eramo, J.L., Somoza, G.M., Libertun, C., (1986) GABA in Endocrine Function, pp. 145-153. , G. Racagni and A.O. Donoso (eds), Raven Press, New York
  • Lux, V.A.R., Somoza, G.M., Libertun, C., (1986) Proc Soc Exp Biol Med, 183, pp. 358-362
  • Lux-Lantos, V.A.R., Somoza, G., Rey, E., Libertun, C., (1991) Proc. Soc. Exp. Biol. Med., 197, pp. 337-341
  • Lux-Lantos, V.A.R., E, R.E.Y., Libertun, C., (1992) Neuroendocrinology, 56, pp. 687-693
  • Rey-Roldan, E.B., Lux-Lantos, V.A.R., Gonzalez Iglesias, A., Becu-Villalobos, D., Libertun, C., (1996) Life Sci, 58, pp. 1059-1065
  • Mattila, J., Mannisto, P.T., (1980) Acta Pharmacol. Toxicol., 46, p. 241
  • Jordan, D., Poncet, C., Veis Seire, M., Mornex, R., (1983) Brain Res., 268, pp. 105-110
  • Tapia-Arancibia, L., Roussel, J.P., Astier, H., (1987) Endocrinology, 121, p. 980
  • Becu, D., Libertun, C., (1982) Endocrinology, 110, pp. 1879-1884
  • Tashjian, A.R., Borowsky, N.J., Jensen, D.K., (1971) Biochemical Biophysical Research Community, 43, p. 516
  • Vale, W., Blackwell, R., Grant, G., Guillemin, R., (1973) Endocrinology, 93, p. 26
  • Lamberts, S.W.J., Macleod, R.M., (1978) Endocrinology, 105, pp. 287-295
  • Becu-Villalobos, D., Lacau-Mengido, I.M., Diaz-Torga, G., Libertun, C., (1992) Cell. Mol. Neurobiol., 12, pp. 1-19
  • Moguilevsky, J.A., Carbone, S., Szwarcfarb, B., (1992) Endocrinology, 131, pp. 458-462
  • Knott, C., Maguire, J.J., Bowery, N.G., (1993) Mol. Brain Res., 18, pp. 353-357
  • Bowery, N.G., Hill, D.R., Hudson, A., Doble, A.L., Middleniss, D.N., Shaw, D., Turnbull, M., (1980) Nature, 283, p. 92
  • Gray, J., Green, A.R., (1987) Br. L. Pharmacol., 91, pp. 517-522
  • Taniyama, K., Niwa, M., Kataoka, Y., Yamashita, K., (1992) J. Neurochem., 58, pp. 1239-1245
  • Loose, M.D., Ronnekleiv, O., Kelly, M.J., (1991) Neuroendocrinology, 54, pp. 537-544
  • D'Eramo, J.L., Somoza, G.M., Kertez, E., Libertun, C., (1986) Eur J Pharmacol, 120, pp. 81-85
  • Fuchs, E., Mansky, T., Stock, K., Vijayan, E., Wuttke, W., (1984) Neuroendocrinology, 38, pp. 484-489
  • Kimura, F., Jinnai, K., Funabashi, T., (1993) Neuroscience Letters, 155, pp. 183-186

Citas:

---------- APA ----------
Rey-Roldán, E.B., Lux-Lantos, V., Chamsoti-Reig, A. & Libertun, C. (1997) . In vivo interaction of baclofen, TRH and serotonin on PRL and TSH secretion in the developing and adult male and female rats. Life Sciences, 61(23), 2283-2290.
http://dx.doi.org/10.1016/S0024-3205(97)00932-6
---------- CHICAGO ----------
Rey-Roldán, E.B., Lux-Lantos, V., Chamsoti-Reig, A., Libertun, C. "In vivo interaction of baclofen, TRH and serotonin on PRL and TSH secretion in the developing and adult male and female rats" . Life Sciences 61, no. 23 (1997) : 2283-2290.
http://dx.doi.org/10.1016/S0024-3205(97)00932-6
---------- MLA ----------
Rey-Roldán, E.B., Lux-Lantos, V., Chamsoti-Reig, A., Libertun, C. "In vivo interaction of baclofen, TRH and serotonin on PRL and TSH secretion in the developing and adult male and female rats" . Life Sciences, vol. 61, no. 23, 1997, pp. 2283-2290.
http://dx.doi.org/10.1016/S0024-3205(97)00932-6
---------- VANCOUVER ----------
Rey-Roldán, E.B., Lux-Lantos, V., Chamsoti-Reig, A., Libertun, C. In vivo interaction of baclofen, TRH and serotonin on PRL and TSH secretion in the developing and adult male and female rats. LIFE SCI. 1997;61(23):2283-2290.
http://dx.doi.org/10.1016/S0024-3205(97)00932-6