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Abstract:

Cultured human peripheral blood mononuclear leukocytes [PBML] from patients with anorexia nervosa [AN] did not respond to light stimulation as PBML of normal controls [NC] did. During winter, visible light increased [3H]thymidine incorporation into DNA of NC-PBML stimulated with phytohemagglutinin [PHA]. This effect was enhanced by 10-7 M melatonin. PHA-stimulated DNA synthesis of PBML from AN patients failed to respond to photic stimulation during winter and their proliferative response to melatonin was significantly blunted. In vitro photic stimulation of NC-PBML reduced melatonin while increasing both serotonin and 5-hydroxyindole 3-acetic acid [HIAA] production in both basal and PHA-stimulated conditions. In contrast AN-PBML, that in darkness enhanced the oxidative deamination of serotonin into HIAA more than NC-PBML, did not switch their indole metabolism in response to light. Light did not inhibit the binding of both melatonin and serotonin to AN-PBML as occurred in NC-PBML. The present data suggest that AN-PBML do not respond to light in vitro, because of a failure in the regulation of serotonin and melatonin metabolism. © 1995.

Registro:

Documento: Artículo
Título:Cultured peripheral blood mononuclear leukocytes from anorexia nervosa patients are refractory to visible light
Autor:Finocchiaro, L.M.E.; Polack, E.; Nahmod, V.E.; Glikin, G.C.
Filiación:Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones Médicas, Universidad de Buenos Aires, Donato Alvarez 3150, 1427 Buenos Aires, Argentina
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Cientificas y Técnicas, y Facultad de Ciencias Exactas y Naturales, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:anorexia nervosa; melatonin; peripheral blood mononuclear leukocytes; serotonin; visible light; 5 hydroxyindoleacetic acid; iodine 125; melatonin; phytohemagglutinin; serotonin; adolescent; adult; anorexia nervosa; article; blood; cell culture; circadian rhythm; clinical article; controlled study; dna synthesis; drug binding; female; human; human cell; leukocyte; monoamine metabolism; mononuclear cell; photostimulation; serotonin metabolism; Adolescent; Adult; Anorexia Nervosa; Cells, Cultured; DNA; Female; Human; Hydroxyindoleacetic Acid; Leukocytes, Mononuclear; Light; Melatonin; Opsin; RNA, Messenger; Seasons; Serotonin; Support, Non-U.S. Gov't
Año:1995
Volumen:57
Número:6
Página de inicio:559
Página de fin:569
DOI: http://dx.doi.org/10.1016/0024-3205(95)00306-Q
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:DNA, 9007-49-2; Hydroxyindoleacetic Acid, 54-16-0; Melatonin, 73-31-4; Opsin; RNA, Messenger; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n6_p559_Finocchiaro

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Citas:

---------- APA ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E. & Glikin, G.C. (1995) . Cultured peripheral blood mononuclear leukocytes from anorexia nervosa patients are refractory to visible light. Life Sciences, 57(6), 559-569.
http://dx.doi.org/10.1016/0024-3205(95)00306-Q
---------- CHICAGO ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C. "Cultured peripheral blood mononuclear leukocytes from anorexia nervosa patients are refractory to visible light" . Life Sciences 57, no. 6 (1995) : 559-569.
http://dx.doi.org/10.1016/0024-3205(95)00306-Q
---------- MLA ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C. "Cultured peripheral blood mononuclear leukocytes from anorexia nervosa patients are refractory to visible light" . Life Sciences, vol. 57, no. 6, 1995, pp. 559-569.
http://dx.doi.org/10.1016/0024-3205(95)00306-Q
---------- VANCOUVER ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C. Cultured peripheral blood mononuclear leukocytes from anorexia nervosa patients are refractory to visible light. Life Sci. 1995;57(6):559-569.
http://dx.doi.org/10.1016/0024-3205(95)00306-Q