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Abstract:

An ovary autotransplanted into the spleen of a bilaterally ovariectomized rat develops into a luteoma, which grows under constant gonadotropin hyperstimulation. The effect of a long-acting GnRH agonist (GnRH-a), on tumor growth and hormone secretion was investigated. Two experimental models were used: Model 1: GnRH-a (0.33 mg/rat sc) or estradiol valenanate (50 μg/rat sc injected once a week for four weeks) was administered simultaneously with ovary implantation; Model 2: the drugs were administered after 1 month of tumor development. The treatment with estradiol was used as a control of tumor regression. Saline injected ovarian grafted rats and Sham operated animals were used as controls. In Model 1: The GnRH-a significantly inhibited tumor development (Positive tumors: Saline: 100% vs GnRH-a: 43%, p < 0.01). In Model 2: the GnRH-a and estradiol significantly reduced the volume of one month old tumors (52% and 39% of initial volumes respectively, p < 0.01). Gonadotropin secretion was significantly inhibited or its increase blunted by the GnRH-a and by estradiol treatments in both models. Estradiol and progesterone in portal blood, which collects the steroids secreted by the luteoma, were significantly reduced by GnRH-a treatment in both models. On the other hand, in tumor cells cultured "in vitro", the GnRH-a was able to inhibit the LH induced progesterone secretion in a concentration dependent way. These results clearly show that the GnRH-a is effective in inhibiting tumor growth or reducing its volume, when already developed; furthermore, it suppresses tumor steroid hormone production. These actions were exerted at both the hypophyseal and tumor levels. © 1995.

Registro:

Documento: Artículo
Título:Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions
Autor:Lux-Lantos, V.A.R.; Thyssen, S.M.; Chamson, A.; Libertun, C.
Filiación:Laboratorio de Neuroendocrinología, Instituto de Biología y Medicina Experimental (CONICET), V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:gonadotropin releasing hormone analog; luteoma; tumor growth; buserelin; estradiol; estradiol valerate; follitropin; gonadorelin agonist; gonadotropin; luteinizing hormone; progesterone; animal cell; animal experiment; animal model; article; autotransplantation; cancer cell culture; cancer graft; cancer inhibition; controlled study; female; hormone blood level; hormone release; nonhuman; ovariectomy; ovary tumor; rat; spleen; subcutaneous drug administration; tumor growth; Animal; Estradiol; Female; Follicle Stimulating Hormone; Gonadorelin; Luteinizing Hormone; Luteoma; Ovarian Neoplasms; Progesterone; Rats; Rats, Sprague-Dawley; Support, Non-U.S. Gov't; Tumor Cells, Cultured; Animalia
Año:1995
Volumen:57
Número:3
Página de inicio:291
Página de fin:300
DOI: http://dx.doi.org/10.1016/0024-3205(95)00272-8
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:Estradiol, 50-28-2; Follicle Stimulating Hormone, 9002-68-0; Gonadorelin, 33515-09-2; Luteinizing Hormone, 9002-67-9; Progesterone, 57-83-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n3_p291_LuxLantos

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Citas:

---------- APA ----------
Lux-Lantos, V.A.R., Thyssen, S.M., Chamson, A. & Libertun, C. (1995) . Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions. Life Sciences, 57(3), 291-300.
http://dx.doi.org/10.1016/0024-3205(95)00272-8
---------- CHICAGO ----------
Lux-Lantos, V.A.R., Thyssen, S.M., Chamson, A., Libertun, C. "Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions" . Life Sciences 57, no. 3 (1995) : 291-300.
http://dx.doi.org/10.1016/0024-3205(95)00272-8
---------- MLA ----------
Lux-Lantos, V.A.R., Thyssen, S.M., Chamson, A., Libertun, C. "Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions" . Life Sciences, vol. 57, no. 3, 1995, pp. 291-300.
http://dx.doi.org/10.1016/0024-3205(95)00272-8
---------- VANCOUVER ----------
Lux-Lantos, V.A.R., Thyssen, S.M., Chamson, A., Libertun, C. Effect of a gonadotropin releasing hormone analog on an experimental ovarian tumor: Direct and indirect actions. Life Sci. 1995;57(3):291-300.
http://dx.doi.org/10.1016/0024-3205(95)00272-8