Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

We have previously reported that estrogen treatment of steroid-free, ovariectomized-adrenalectomized (OVX-ADX) rats, increased binding to glucocorticoid type II receptors (GR) in some brain regions. The present report studied the effects of estradiol in OVX-ADX rats receiving chronic corticosterone (CORT) treatment. Using binding assays, GR was reduced by CORT replacement in cytosol of hippocampus and septum, but not in whole hypothalamus. GR were recovered after 4 days of estradiol therapy. Using Mab7, a monoclonal antibody against the activated nuclear form of GR, we observed that estrogen treatment increased immunoreactivity measured by computerized densitometry in areas targeted by glucocorticoids. Significantly higher staining for GR developed in CA1 and CA2 hippocampal subfields, paraventricular nucleus of the hypothalamus and lateral ventral septal nuclei of estradiol-receiving, CORT-treated OVX-ADX rats. The amplification of the glucocorticoid biological signal by female sex hormones, may thus affect several neuroendocrine parameters and the outcome of stressrelated diseases. © 1995.

Registro:

Documento: Artículo
Título:Estradiol abolishes autologous down regulation of glucocorticoid receptors in brain
Autor:Ferrini, M.; Lima, A.; De Nicola, A.F.
Filiación:Laboratorio de Bioquímica Neuroendócrina, Instituto de Biología y Medicina Experimental UBACONICET, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:down regulation; estradiol; glucocorticoid; glucocorticoid receptors; immunocytochemistry; 11beta,17beta dihydroxy 6 methyl 17alpha (1 propynyl)androsta 1,4,6 trien 3 one; corticosterone; dexamethasone; estradiol; glucocorticoid antagonist; glucocorticoid receptor; monoclonal antibody; monoclonal antibody mab7; radioligand; receptor subtype; unclassified drug; adrenalectomy; animal experiment; animal model; animal tissue; article; brain region; controlled study; cytosol; female; hippocampus; hypothalamus; immunocytochemistry; nonhuman; oral drug administration; ovariectomy; rat; receptor binding; receptor down regulation; septum nucleus; stress; subcutaneous drug administration; thalamus midline nucleus; Adrenalectomy; Animal; Antibodies, Monoclonal; Brain; Corticosterone; Densitometry; Down-Regulation; Estradiol; Female; Glucocorticoids; Immunoenzyme Techniques; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Support, Non-U.S. Gov't; Animalia
Año:1995
Volumen:57
Número:26
Página de inicio:2403
Página de fin:2412
DOI: http://dx.doi.org/10.1016/0024-3205(95)02236-3
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:Antibodies, Monoclonal; Corticosterone, 50-22-6; Estradiol, 50-28-2; Glucocorticoids; Receptors, Glucocorticoid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n26_p2403_Ferrini

Referencias:

  • Reul, De Kloet, (1985) Endocrinology, 117, pp. 2505-2512
  • Ewen, De Kloet, Rostene, (1986) Physiol Rev, 66, pp. 1121-1188
  • Luttge, Davda, Rupp, Kang, (1989) Endocrinology, 125, pp. 1194-1203
  • Moses, Gonzalez, Ewen, De Nicola, (1991) J Steroid Biochem Molec Biol, 39, pp. 5-12
  • Reul, Van Den Bosch, De Kloet, (1987) Neuroendocrinology, 45, pp. 407-412
  • Tornello, Orti, De Nicola, Rainbow, Ewen, (1982) Neuroendocrinology, 35, pp. 411-417
  • Sapolsky, Krey, Ewen, (1986) Endocr Rev, 7, pp. 284-301
  • Dallman, Akana, Cascio, Darlington, Jacobson, Levin, (1987) Rec Progr Horm Res, 43, pp. 113-120
  • Lanfield, Eldridge, Evolving aspects of the glucocorticoid hypothesis of brain aging: Hormonal modulation of neuronal calcium homeostasis (1994) Neurobiology of Aging, 15, pp. 579-588
  • ewen, Angulo, Cameron, Chao, Daniels, Gannon, Gould, Woolley, (1992) Biol Psychiat, 31, pp. 177-199
  • Munck, Guyre, Holbrook, (1984) Endocr Rev, 5, pp. 25-44
  • Kitay, (1961) Endocrinology, 68, pp. 818-824
  • Critchlow, Liebelt, Bar-Seta, Mountcastle, Lipscomb, (1963) Am J Physiol, 205, pp. 807-815
  • Turner, Weaver, (1985) Brain Res, 343, pp. 16-23
  • Turner, (1990) Life Sci, 46, pp. 1399-1406
  • Turner, (1992) Brain Res, 581, pp. 229-236
  • Ferrini, De Nicola, (1991) Life Sci, 48, pp. 2593-2601
  • Ferrini, Gonzalez, Nicola, (1993) Life Sci., 52, pp. 677-685
  • Redei, Ll, Halasz, Givern, Aird, (1994) Neuroendocrinology, 60, pp. 113-123
  • Weisenberg, Fridman, Libertun, De Nicola, (1983) J Steroid Biochem, 19, pp. 1737-1741
  • Magariños, Ferrini, De Nicola, (1989) Neuroendocrinology, 50, pp. 673-678
  • Lowry, Rosebrough, Farr, Randall, (1951) J Biol Chem, 192, pp. 265-275
  • Fuxe, Wikstrom, Okret, Agnati, Harfstrand, Yu, Granholm, Gustafsson, (1985) Endocrinology, 117, pp. 1803-1812
  • Okret, Wikstrom, Wrange, Andersson, Gustafsson, (1984) Proc Natl Acad Sci USA, 81, pp. 1609-1613. , second edition
  • Wikstrom, Bakke, Okret, Bronnegard, Gustafsson, (1987) Endocrinology, 120, pp. 1232-1242
  • Paxinos, Watson, (1982) The rat brain in stereotaxic coordinates, , Academic Press, N.Y
  • Van Eekelen, Kiss, Westphal, De Kloet, Immunocytochemical study on the intracellular localization of the type 2 glucocorticoid receptor in the rat brain (1987) Brain Research, 436, pp. 120-128
  • Brinton, Ewen, (1988) Neurosci Res Comm, 2, pp. 37-45
  • Burnstein, Cidlowsky, (1992) Mol Cell Endocrinol, 83, pp. C1-C8
  • Burguess, Handa, (1992) Endocrinology, 131, pp. 1261-1269
  • Ahima, Garcia, Harlan, (1992) Proc Soc Exp Biol Med, 201, pp. 244-253. , second edition
  • T. ANTAKLY, S. MERCILLE, J. P. COTE, Endocrinology 120 1558–1562, 19; Maggi, Susanna, Bettini, Mantero, Zucchi, (1989) Mol Endocrinol., 3, pp. 1165-1170
  • Axelson, Van Leewen, (1990) J. Neuroendocrinol, 2, pp. 209-216
  • Sheridan, (1988) Cell Tiss Res, 183, pp. 379-384
  • Moguilevsky, Raynaud, Estrogen-sensitive progestin-binding sites in the female rat brain and pituitary (1979) Brain Research, 164, pp. 165-175
  • Pfeiffer, Barden, (1988) Mol Cell Endocrinol, 55, pp. 115-120
  • Sawchenko, Swanson, Vale, (1984) Proc Natl Acad Sci USA, 81, pp. 1883-1887. , second edition
  • Sawchenko, (1987) Brain Res, 403, pp. 213-224
  • Kovacs, Kiss, Makara, (1986) Neuroendocrinology, 44, pp. 229-234
  • Haas, George, (1988) Brain Res Bull, 20, pp. 361-367
  • Swanson, Simmons, (1989) J Comp Neurol, 285, pp. 413-435
  • De Vries, Wang, Bullock, Numan, (1994) J Neurosci, 14, pp. 1789-1794
  • Scheff, Morse, De Kosky, (1988) Exp Neurol, 100, pp. 237-241
  • Uno, Tarara, Else, Suleman, Sapolsky, (1989) J Neurosci, 9, pp. 1705-1711
  • Herman, (1993) Cell Mol Neurobiol, 13, pp. 349-372
  • Gould, Woolley, Frankfurt, Ewen, (1990) J Neurosci, 10, pp. 1286-1291
  • Woolley, Ewen, (1992) J Neurosci, 12, pp. 2549-2554
  • Sapolsky, (1990) Progr Brain Res, 86, pp. 13-23
  • Sloviter, Valiquette, Abrams, (1989) Science, 243, pp. 535-538
  • Magariños, Somoza, De Nicola, Glucocorticoid Negative Feedback and Glucocorticoid Receptors After Hippocampectomy in Rats (1987) Hormone and Metabolic Research, 19, pp. 105-109
  • Valeri, Angelucci, Palmeri, (1978) Neurosci Lett, 9, pp. 249-254
  • Tornello, Fridman, Weisenberg, Coirini, De Nicola, (1981) J., Steroid Biochem, 14, pp. 77-81
  • Ewen, Cameron, Chao, Gould, Magariños, Watanabe, Woolley, (1993) Cell Mol Neurobiol, 13, pp. 454-482
  • Herman, Schafer, Young, Thompson, Douglas, Akil, Watson, (1989) J Neurosci, 9, pp. 3072-3082
  • Jones, (1988) Metab Brain Dis, 3, pp. 1-18

Citas:

---------- APA ----------
Ferrini, M., Lima, A. & De Nicola, A.F. (1995) . Estradiol abolishes autologous down regulation of glucocorticoid receptors in brain. Life Sciences, 57(26), 2403-2412.
http://dx.doi.org/10.1016/0024-3205(95)02236-3
---------- CHICAGO ----------
Ferrini, M., Lima, A., De Nicola, A.F. "Estradiol abolishes autologous down regulation of glucocorticoid receptors in brain" . Life Sciences 57, no. 26 (1995) : 2403-2412.
http://dx.doi.org/10.1016/0024-3205(95)02236-3
---------- MLA ----------
Ferrini, M., Lima, A., De Nicola, A.F. "Estradiol abolishes autologous down regulation of glucocorticoid receptors in brain" . Life Sciences, vol. 57, no. 26, 1995, pp. 2403-2412.
http://dx.doi.org/10.1016/0024-3205(95)02236-3
---------- VANCOUVER ----------
Ferrini, M., Lima, A., De Nicola, A.F. Estradiol abolishes autologous down regulation of glucocorticoid receptors in brain. Life Sci. 1995;57(26):2403-2412.
http://dx.doi.org/10.1016/0024-3205(95)02236-3