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Abstract:

Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10-9 to 10-5 M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10-9 to 10-7 M) stimulated [3H]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production. © 1995.

Registro:

Documento: Artículo
Título:Sensitivity of human peripheral blood mononuclear leukocytes to visible light
Autor:Finocchiaro, L.M.E.; Polack, E.; Nahmod, V.E.; Glikin, G.C.
Filiación:Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones Médicas, Universidad de Buenos Aires, Donate Alvarez 3150, 1427 Buenos Aires, Argentina
Instituto de Investigaciones en Ingenieria Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, y Facultad de Ciencias Exactas y Naturales, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:melatonin; peripheral blood mononuclear leukocytes; serotonin; visible light; 5 hydroxyindoleacetic acid; melatonin; phytohemagglutinin; serotonin; thymidine; thymidine h 3; unclassified drug; article; controlled study; dna replication; dna synthesis; human; human cell; light; membrane binding; monocyte; Base Sequence; Cells, Cultured; DNA; DNA Primers; Gene Expression; Human; In Vitro; Indoles; Leukocytes, Mononuclear; Light; Melatonin; Molecular Sequence Data; Opsin; Serotonin; Support, Non-U.S. Gov't
Año:1995
Volumen:57
Número:11
Página de inicio:1097
Página de fin:1110
DOI: http://dx.doi.org/10.1016/0024-3205(95)02055-N
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:DNA Primers; DNA, 9007-49-2; Indoles; Melatonin, 73-31-4; Opsin; Serotonin, 50-67-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n11_p1097_Finocchiaro

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Citas:

---------- APA ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E. & Glikin, G.C. (1995) . Sensitivity of human peripheral blood mononuclear leukocytes to visible light. Life Sciences, 57(11), 1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N
---------- CHICAGO ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C. "Sensitivity of human peripheral blood mononuclear leukocytes to visible light" . Life Sciences 57, no. 11 (1995) : 1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N
---------- MLA ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C. "Sensitivity of human peripheral blood mononuclear leukocytes to visible light" . Life Sciences, vol. 57, no. 11, 1995, pp. 1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N
---------- VANCOUVER ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C. Sensitivity of human peripheral blood mononuclear leukocytes to visible light. Life Sci. 1995;57(11):1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N