Abstract:
Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10-9 to 10-5 M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10-9 to 10-7 M) stimulated [3H]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production. © 1995.
Registro:
Documento: |
Artículo
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Título: | Sensitivity of human peripheral blood mononuclear leukocytes to visible light |
Autor: | Finocchiaro, L.M.E.; Polack, E.; Nahmod, V.E.; Glikin, G.C. |
Filiación: | Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones Médicas, Universidad de Buenos Aires, Donate Alvarez 3150, 1427 Buenos Aires, Argentina Instituto de Investigaciones en Ingenieria Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, y Facultad de Ciencias Exactas y Naturales, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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Palabras clave: | melatonin; peripheral blood mononuclear leukocytes; serotonin; visible light; 5 hydroxyindoleacetic acid; melatonin; phytohemagglutinin; serotonin; thymidine; thymidine h 3; unclassified drug; article; controlled study; dna replication; dna synthesis; human; human cell; light; membrane binding; monocyte; Base Sequence; Cells, Cultured; DNA; DNA Primers; Gene Expression; Human; In Vitro; Indoles; Leukocytes, Mononuclear; Light; Melatonin; Molecular Sequence Data; Opsin; Serotonin; Support, Non-U.S. Gov't |
Año: | 1995
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Volumen: | 57
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Número: | 11
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Página de inicio: | 1097
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Página de fin: | 1110
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DOI: |
http://dx.doi.org/10.1016/0024-3205(95)02055-N |
Título revista: | Life Sciences
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Título revista abreviado: | Life Sci.
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ISSN: | 00243205
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CODEN: | LIFSA
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CAS: | DNA Primers; DNA, 9007-49-2; Indoles; Melatonin, 73-31-4; Opsin; Serotonin, 50-67-9
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n11_p1097_Finocchiaro |
Referencias:
- Maestroni, (1993) J. Pineal Res., 14, pp. 1-10
- Vaughan, Hubbard, Chamopney, Vaughan, Little, Reiter, (1987) Am.J. Anat., 179, pp. 131-136
- Preslock, (1984) Endocrin Revs., 5, pp. 282-308
- Reiter, (1993) Experientia, 49, pp. 654-664
- Binkley, (1993) Experientia, 49, pp. 648-653
- Poeggeler, (1993) Experientia, 49, pp. 611-613
- Cahill, Besharse, (1992) Vis. Neurosci., 8, pp. 487-490
- Menaker, Underwood, (1976) Photochem. Photobiol., 23, pp. 299-306
- Albrecht-Buehler, (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 8288-8292. , 2nd Ed
- Bradley, Sharkey, (1977) Nature, 266, pp. 724-726
- Parshad, Sanford, Jones, Price, Taylor, (1977) Exp. Cell Res., 104, pp. 199-205
- Binkley, Geller, (1975) Endocrinology, 96, pp. 848-853
- Pevet, Balemans, Legerstee, Vivien-Roels, (1980) J. Neur. Trans., 49, pp. 229-245
- Huether, (1993) Experientia, 49, pp. 665-670
- Cahill, Besharse, (1993) Neuron, 10, pp. 573-577
- Finocchiaro, Arzt, Fernandez-Castelo, Criscuolo, Finkielman, Nahmod, (1988) J. Interferon Res., 8, pp. 705-716
- Finocchiaro, Nahmod, Launay, (1991) Biochem. J., 280, pp. 727-731
- Lopez-Gonzalez, Calvo, Osuna, Guerrero, (1992) J. Pineal Res., 12, pp. 97-104
- Boyum, The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration (1968) Scandinavian Journal of Clinical & Laboratory Investigation, 21, pp. 77-81
- Arzt, Fernandez-Castelo, Finocchiaro, Criscuolo, Diaz, Finkielman, Nahmod, (1988) J. Clin. Immunol., 8, pp. 513-520
- Finocchiaro, Callebert, Launay, Jallon, (1988) J. Neurochem., 50, pp. 382-388
- Araki, Taketani, (1992) Dev. Brain Res., 69, pp. 149-152
- Nathans, Hogness, (1984) Proc. Natl. Acad. Sci. USA, 81, pp. 4851-4855. , 2nd Ed
- Lowry, Resebrough, Farr, Randall, (1951) J. Biol. Chem., 193, pp. 265-275
- Klein, Notides, (1969) Anal. Biochem., 31, pp. 480-483
- Withyachumnarnkul, Nonaka, Attia, Reiter, (1990) J. Pineal Res., 8, pp. 313-322
- Klein, Weller, (1972) Science, 177, pp. 532-533
- Cremer-Bartels, Ebels, (1980) Proc. Natl. Acad. Sci. USA, 77, pp. 2415-2418. , 2nd Ed
- Quay, (1968) Archs. Anat. Histol. et Embryol., 51, pp. 567-571
- Poon, Pang, (1992) Life Sci., 50, pp. 1719-1726
- Poon, Wang, Pang, (1993) J. Pineal Res., 14, pp. 169-177
- Yu, Yuan, Lu, Pang, (1991) Neurosci. Lett., 125, pp. 175-178
- Liu, Pang, Binding of [125I]-Labelled lodomelatonin in the Duck Thymus (1992) Neurosignals, 1, pp. 208-217
- Ferguson, Mahendra, Hooper, Kaplan, (1992) Invest. Ophthalmol. Vis. Sci., 33, pp. 1788-1795
- Poeggeler, Reiter, Tan, Chen, Manchester, (1993) J. Pineal Res., 14, pp. 151-168
- Morrey, McLachlan, Serkin, Bakouche, (1994) J. Immunol., 153, pp. 2671-2680
- Meyer, Schreck, Baeuerle, (1993) EMBO J., 12, pp. 2005-2015
- Galter, Mihm, Droge, (1994) Eur.J. Biochem., 221, pp. 639-648
- Hardeland, Reiter, Poeggeler, Tan, (1993) Neurosci. Biobehav. Rev., 17, pp. 347-357
- Bartness, Goldman, (1989) Experientia, 45, pp. 939-945
- Laitinen, Castre, Vakkuri, Saavedra, (1989) Endocrinology, 124, pp. 1585-1587
- Nathans, Thomas, Hogness, (1986) Science, 232, pp. 193-202
- Araki, Fukada, Shichida, Yoshizawa, Tokunaga, (1992) Dev. Brain Res., 65, pp. 85-92
- Reiter, Richardson, (1992) Chronobiol. Int., 9, pp. 314-321
- Finocchiaro, Polack, Nahmod, Glikin, (1995) accompanying paper
- Hardeland, (1993) Experientia, 49, pp. 614-622
Citas:
---------- APA ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E. & Glikin, G.C.
(1995)
. Sensitivity of human peripheral blood mononuclear leukocytes to visible light. Life Sciences, 57(11), 1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N---------- CHICAGO ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C.
"Sensitivity of human peripheral blood mononuclear leukocytes to visible light"
. Life Sciences 57, no. 11
(1995) : 1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N---------- MLA ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C.
"Sensitivity of human peripheral blood mononuclear leukocytes to visible light"
. Life Sciences, vol. 57, no. 11, 1995, pp. 1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N---------- VANCOUVER ----------
Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., Glikin, G.C. Sensitivity of human peripheral blood mononuclear leukocytes to visible light. Life Sci. 1995;57(11):1097-1110.
http://dx.doi.org/10.1016/0024-3205(95)02055-N