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Abstract:

Previous results demonstrated that estradiol (E2) treatment of ovariectomized-adrenalectomized (OVX-ADX) rats increased glucocorticoid (GC) binding in brain regions. The experimental protocol was extended to the spinal cord, a GC target tissue in which ornithine decarboxylase (ODC) is markedly induced by GC treatment. First, we measured GC binding to type I and type II receptors in ventral horn, dorsal horn and lateral funiculus of OVX-ADX rats treated during 4 days with E2 or vehicle. In E2-treated rats, type II receptors increased solely in dorsal horn, whereas type I sites remained unchanged. Second, in a group of OVX-ADX rats receiving dexamethasone (DEX), pretreatment with E2 superinduced ODC in ventral horn and lateral funiculus, but not in dorsal horn. Third, we found that the dorsal horn was relatively enriched in E2 receptors compared to other areas. Therefore, E2 stimulation of GC binding to type II sites may be mediated through E2 receptors localized in the dorsal horn. We suggest that combined treatment with E2 and DEX employs a transsynaptic mechanism for ODC induction at the ventral horn and lateral funiculus, with hormonal interaction taking place at the dorsal horn level. © 1993.

Registro:

Documento: Artículo
Título:Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord
Autor:Ferrini, M.; González, S.; De Nicola, A.F.
Filiación:Laboratorio de Bioquímica Neuroendócrina, Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:dexamethasone; estradiol; estradiol receptor; glucocorticoid receptor; ornithine decarboxylase; radioligand; adrenalectomy; animal experiment; animal tissue; article; binding site; controlled study; enzyme induction; female; nonhuman; ovariectomy; priority journal; rat; spinal cord; spinal cord dorsal horn; spinal cord ventral horn; subcutaneous drug administration; Adrenalectomy; Analysis of Variance; Animal; Enzyme Induction; Estradiol; Female; Glucocorticoids; Ornithine Decarboxylase; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Spinal Cord; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Animalia
Año:1993
Volumen:52
Número:7
Página de inicio:677
Página de fin:685
DOI: http://dx.doi.org/10.1016/0024-3205(93)90460-K
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:Estradiol, 50-28-2; Glucocorticoids; Ornithine Decarboxylase, EC 4.1.1.17; Receptors, Glucocorticoid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v52_n7_p677_Ferrini

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Citas:

---------- APA ----------
Ferrini, M., González, S. & De Nicola, A.F. (1993) . Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord. Life Sciences, 52(7), 677-685.
http://dx.doi.org/10.1016/0024-3205(93)90460-K
---------- CHICAGO ----------
Ferrini, M., González, S., De Nicola, A.F. "Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord" . Life Sciences 52, no. 7 (1993) : 677-685.
http://dx.doi.org/10.1016/0024-3205(93)90460-K
---------- MLA ----------
Ferrini, M., González, S., De Nicola, A.F. "Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord" . Life Sciences, vol. 52, no. 7, 1993, pp. 677-685.
http://dx.doi.org/10.1016/0024-3205(93)90460-K
---------- VANCOUVER ----------
Ferrini, M., González, S., De Nicola, A.F. Estradiol increases glucocorticoid binding and glucocorticoid induction of ornithine decarboxylase in the rat spinal cord. Life Sci. 1993;52(7):677-685.
http://dx.doi.org/10.1016/0024-3205(93)90460-K