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Abstract:

The ontogeny of diazepam's endocrine effects in male and female rats, and of 3H-diazepam binding in the hypothalami of both sexes was studied. Diazepam inhibited basal prolactin levels in 38 day-old male rats and, if prolactin levels were stimulated by Haloperidol the inhibition occurred in 28 day-old males, indicating that the hypoprolactinemic effect of the drug could be evidenced earlier if prolactin titers were high. The prolactin inhibition in females did not reach statistical significance at any studied age. Diazepam significantly released LH only in male rats at 12 days, showing thus, a period of special sensitivity of LH release to the drug. Benzodiazepine-hypothalamic binding sites increased in number from birth to puberty, reaching a plateau at 20 days of age. No sexual differences or changes in affinity were found throughout the studied period. These results suggest that the maturtion of diazepam's hypoprolactinemic effect could be partially related to the increase in hypothalamic binding sites, whereas the sexual differences observed in diazepam's endocrine actions could be due to sexual differentiation of endocrine control mechanisms. © 1989.

Registro:

Documento: Artículo
Título:Diazapam: Endocrine effects and hypothalamic binding sites in the developing male and female rat
Autor:Lacau de Mengido, I.M.; Diaz-Torga, G.S.; Libertun, C.
Filiación:Instituto de Biología y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:benzodiazepine receptor; diazepam; haloperidol; prolactin; radioisotope; 4 aminobutyric acid A receptor; diazepam; haloperidol; luteinizing hormone; prolactin; Receptors, GABA A; thyrotropin; adolescent; age; animal cell; animal experiment; controlled study; drug effect; female; hormone blood level; hypothalamus; intraperitoneal drug administration; luteinizing hormone release; male; newborn; nonhuman; ontogeny; priority journal; rat; sex difference; animal; article; binding site; biosynthesis; blood; hypothalamus; metabolism; rat strain; sexual development; sexual maturation; Animal; Binding Sites; Diazepam; Female; Haloperidol; Hypothalamus; Luteinizing Hormone; Male; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sex Characteristics; Sex Maturation; Thyrotropin
Año:1989
Volumen:45
Número:7
Página de inicio:567
Página de fin:575
DOI: http://dx.doi.org/10.1016/0024-3205(89)90041-6
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:diazepam, 439-14-5; haloperidol, 52-86-8; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; luteinizing hormone, 39341-83-8, 9002-67-9; thyrotropin, 9002-71-5; Diazepam, 439-14-5; Haloperidol, 52-86-8; Luteinizing Hormone, 9002-67-9; Prolactin, 9002-62-4; Receptors, GABA-A; Thyrotropin, 9002-71-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v45_n7_p567_LacaudeMengido

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Citas:

---------- APA ----------
Lacau de Mengido, I.M., Diaz-Torga, G.S. & Libertun, C. (1989) . Diazapam: Endocrine effects and hypothalamic binding sites in the developing male and female rat. Life Sciences, 45(7), 567-575.
http://dx.doi.org/10.1016/0024-3205(89)90041-6
---------- CHICAGO ----------
Lacau de Mengido, I.M., Diaz-Torga, G.S., Libertun, C. "Diazapam: Endocrine effects and hypothalamic binding sites in the developing male and female rat" . Life Sciences 45, no. 7 (1989) : 567-575.
http://dx.doi.org/10.1016/0024-3205(89)90041-6
---------- MLA ----------
Lacau de Mengido, I.M., Diaz-Torga, G.S., Libertun, C. "Diazapam: Endocrine effects and hypothalamic binding sites in the developing male and female rat" . Life Sciences, vol. 45, no. 7, 1989, pp. 567-575.
http://dx.doi.org/10.1016/0024-3205(89)90041-6
---------- VANCOUVER ----------
Lacau de Mengido, I.M., Diaz-Torga, G.S., Libertun, C. Diazapam: Endocrine effects and hypothalamic binding sites in the developing male and female rat. Life Sci. 1989;45(7):567-575.
http://dx.doi.org/10.1016/0024-3205(89)90041-6