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Abstract:

We have evaluated the effect of R05-4864, a selective probe to label peripheral type benzodiazepine receptor, on "in vitro" testicular androgen production. Decapsulated testes from adult rats showed a significant increase in the basal and hCG-stimulated testosterone secretion into the medium in response to 10-5M, 10-6M, and 10-7M Ro5-4864. In addition, we have studied the changes in testicular GABA content at three different ages and we found its highest concentration at 31 days of age. When we evaluated the effect of GABA on "in vitro" androgen production at different stages of gonadal maturation we observed that the highest concentration of GABA (10-6M) was able to modify the basal and hCG-stimulated androgen production from adult (60 days) and pubertal (45 days) testes. In addition, when prepubertal testes (31 days) were incubated under basal conditions, 10-6M GABA induced a significant increment of androstanediol production, while the stimulatory effect of hCG was reduced in the presence of the same GABA concentration. The present results suggest that GABA plays a physiological role in the regulation of rat testicular androgen production depending on the stage of sexual maturation. © 1987.

Registro:

Documento: Artículo
Título:Effect of GABA and benzodiazepines on testicular androgen production
Autor:Ritta, M.N.; Campos, M.B.; Calandra, R.S.
Filiación:Instituto de Biología y Medicina Experimental (IBYME). Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:4 aminobutyric acid; 4' chlorodiazepam; androstanediol; benzodiazepine; chorionic gonadotropin; muscimol h 3; testosterone; unclassified drug; age; androgen metabolism; animal cell; animal experiment; dose response; drug accumulation; drug analysis; drug determination; drug interaction; drug mechanism; drug monitoring; drug response; drug tissue level; male genital system; nonhuman; pharmacokinetics; physiology; priority journal; rat; testis; Age Factors; Androgens; Animal; Benzodiazepinones; Chorionic Gonadotropin; gamma-Aminobutyric Acid; Male; Rats; Receptors, GABA-A; Sex Maturation; Support, Non-U.S. Gov't; Testis
Año:1987
Volumen:40
Número:8
Página de inicio:791
Página de fin:798
DOI: http://dx.doi.org/10.1016/0024-3205(87)90307-9
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:4 aminobutyric acid, 28805-76-7, 56-12-2; 4' chlorodiazepam, 14439-61-3; androstanediol, 1852-53-5, 25126-76-5, 67332-38-1; benzodiazepine, 12794-10-4; chorionic gonadotropin, 9002-61-3; testosterone, 58-22-0; 4'-chlorodiazepam, 14439-61-3; Androgens; Benzodiazepinones; Chorionic Gonadotropin; gamma-Aminobutyric Acid, 56-12-2; Receptors, GABA-A
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v40_n8_p791_Ritta

Referencias:

  • Braestrup, Squires, (1977) Proc. Nat. Acad. Sci. (USA), 74, pp. 3805-3809
  • Taniguchi, Wang, Spector, [3H]Diazepam binding sites on rat heart and kidney (1982) Biochemical Pharmacology, 31, pp. 589-590
  • Taniguchi, Wang, Spector, (1980) Life Sci., 27, pp. 171-178
  • Wang, Taniguchi, Spector, (1980) Life Sci., 17, pp. 1881-1888
  • H. BENAVIDEZ, C. MALGOURIS, F. IMBAULT, F. BEGASSAT, A. UZAN, C. RENAULT, M. DUBROEUCQ, C. GUEREMY and G. LE FUR, G. Arch. Int. Pharmacodyn., in press; Schoemaker, Bliss, Yamamura, (1981) Eur. J. Pharmacol., 71, pp. 173-175
  • Davies, Huston, (1982) Eur. J. Pharmacol., 73, pp. 209-211
  • de Souza, Arnholt, Murphy, Snyder, Kuhar, (1985) Endocrinology, 116, pp. 567-573
  • Wilkinson, Moger, Grovestine, (1980) Life Sci., 27, pp. 2285-2289
  • Muller, (1981) Pharmacology, 22, pp. 153-156
  • Haefely, Polc, Pieri, Schaffner, Laurent, (1983) The Benzodiazepines: From Biology to Clinical Practice, p. 21. , E. Costa, Raven Press, New York
  • Roberts, (1979) Advances in Pharmacology and Therapeutics, 2, p. 43. , P. Simon, Pergamon Press, New York
  • Erdo, Rosdy, Szporny, (1982) J. Neurochem., 38, pp. 1174-1176
  • Suescun, Gonzalez, Chiauzzi, Calandra, (1985) J. Androl., 6, pp. 77-82
  • Suescun, Campo, Rivarola, Gonzalez-Echeverria, Scorticati, Ghirlanda, Tezon, Calandra, (1981) Arch. Androl., 7, pp. 297-303
  • Bernasconi, Bittiger, Heid, Martin, (1980) J. Neurochem, 34, pp. 614-618
  • Graham, Aprison, (1966) Analyt. Biochem., 15, pp. 487-497
  • Li, (1964) Introduction to experimental statistics, , McGraw-Hill, New York
  • Cook, Notelovitz, Kalra, (1979) Arch. Androl., 3, pp. 31-34
  • Squires, (1984) Handbook of Neurochemistry, 6, p. 261. , A. Lajtha, Plenum Press, New York
  • del Rio, (1981) J. Biol. Chem., 256, pp. 9816-9819
  • Erdo, (1985) Trends Pharmacol. Sci., 6, pp. 205-208
  • Apud, Tappaz, Celotti, Negri-Cressi, Massotto, Racagni, (1984) J. Neurochem., 43, pp. 120-125
  • Fernandez, del Rio, Oresanz, (1985) Life Sci., 36, pp. 1733-1737
  • Vijayan, McCann, (1979) Brain Res., 155, pp. 35-39
  • Apud, Racagni, Iuliano, Cocchi, Casanueva, Muller, (1981) Endocrinology, 108, pp. 1505-1509
  • Grandison, Guidotti, (1979) Endocrinology, 105, pp. 754-759

Citas:

---------- APA ----------
Ritta, M.N., Campos, M.B. & Calandra, R.S. (1987) . Effect of GABA and benzodiazepines on testicular androgen production. Life Sciences, 40(8), 791-798.
http://dx.doi.org/10.1016/0024-3205(87)90307-9
---------- CHICAGO ----------
Ritta, M.N., Campos, M.B., Calandra, R.S. "Effect of GABA and benzodiazepines on testicular androgen production" . Life Sciences 40, no. 8 (1987) : 791-798.
http://dx.doi.org/10.1016/0024-3205(87)90307-9
---------- MLA ----------
Ritta, M.N., Campos, M.B., Calandra, R.S. "Effect of GABA and benzodiazepines on testicular androgen production" . Life Sciences, vol. 40, no. 8, 1987, pp. 791-798.
http://dx.doi.org/10.1016/0024-3205(87)90307-9
---------- VANCOUVER ----------
Ritta, M.N., Campos, M.B., Calandra, R.S. Effect of GABA and benzodiazepines on testicular androgen production. Life Sci. 1987;40(8):791-798.
http://dx.doi.org/10.1016/0024-3205(87)90307-9