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Abstract:

The effect of anti β adrenoceptor IgG from chagasic sera upon Ca2+-ATPase and Na++K+-ATPase of myocardial membrane was studied. Chagasic IgG stimulated Ca2+-ATPase and inhibited Na++K+-ATPase activities. Both enzymatic effects of the IgG could be prevented after β adrenoceptor blockade or after the absorption of chagasic IgG with turkey red blood cells. Isoproterenol acted similarly. These results provide information concerning to the biochemical mechanism, by which an antibody, known to activate adenylate cyclase system coupled to cardiac β adrenoceptor, produces stimulation of myocardial contractility. © 1987.

Registro:

Documento: Artículo
Título:Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism
Autor:Pascual, J.; Borda, E.; Sterin-Borda, L.
Filiación:Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN). Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Re, 1414 Buenos Aires, Argentina
Palabras clave:adenosine triphosphatase (calcium magnesium); adenosine triphosphatase (calcium); adenosine triphosphatase (potassium sodium); Adrenergic beta Agonists; beta adrenergic receptor; beta adrenergic receptor stimulating agent; Ca(2+) Mg(2+) ATPase; Ca(2+) Transporting ATPase; immunoglobulin G; isoprenaline; Na(+) K(+) Exchanging ATPase; propranolol; adult; animal; article; Chagas disease; enzymology; erythrocyte; guinea pig; human; immunology; male; metabolism; physiology; sarcolemma; turkey (bird); Adrenergic beta-Agonists; Adult; Animal; Ca(2+) Mg(2+)-ATPase; Ca(2+)-Transporting ATPase; Chagas Disease; Erythrocytes; Guinea Pigs; Human; Immunoglobulin G; Isoproterenol; Male; Na(+)-K(+)-Exchanging ATPase; Propranolol; Receptors, Adrenergic, beta; Sarcolemma; Support, Non-U.S. Gov't; Turkeys
Año:1987
Volumen:40
Número:4
Página de inicio:313
Página de fin:319
DOI: http://dx.doi.org/10.1016/0024-3205(87)90131-7
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:immunoglobulin G, 97794-27-9; isoprenaline, 299-95-6, 51-30-9, 6700-39-6, 7683-59-2; propranolol, 13013-17-7, 318-98-9, 3506-09-0, 4199-09-1, 525-66-6; Adrenergic beta-Agonists; Ca(2+) Mg(2+)-ATPase, EC 3.6.1.-; Ca(2+)-Transporting ATPase, EC 3.6.1.38; Immunoglobulin G; Isoproterenol, 7683-59-2; Na(+)-K(+)-Exchanging ATPase, EC 3.6.1.37; Propranolol, 525-66-6; Receptors, Adrenergic, beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v40_n4_p313_Pascual

Referencias:

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Citas:

---------- APA ----------
Pascual, J., Borda, E. & Sterin-Borda, L. (1987) . Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism. Life Sciences, 40(4), 313-319.
http://dx.doi.org/10.1016/0024-3205(87)90131-7
---------- CHICAGO ----------
Pascual, J., Borda, E., Sterin-Borda, L. "Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism" . Life Sciences 40, no. 4 (1987) : 313-319.
http://dx.doi.org/10.1016/0024-3205(87)90131-7
---------- MLA ----------
Pascual, J., Borda, E., Sterin-Borda, L. "Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism" . Life Sciences, vol. 40, no. 4, 1987, pp. 313-319.
http://dx.doi.org/10.1016/0024-3205(87)90131-7
---------- VANCOUVER ----------
Pascual, J., Borda, E., Sterin-Borda, L. Chagasic IgG modifies the activity of sarcolemmal ATPases through a β adrenergic mechanism. Life Sci. 1987;40(4):313-319.
http://dx.doi.org/10.1016/0024-3205(87)90131-7