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Abstract:

The spontaneous 3H-noradrenaline efflux from the isolated epididymal and prostatic portions of the rat vas deferens, was investigated. The spontaneous tritium efflux was higher in the epididymal portion than in the prostatic one from normal animals. Such differences were abolished after castration. On the other hand, acetylsalicylic acid enhanced the total tritium efflux only in the epididymal portion, whereas phentolamine and phenoxybenzamine increased the total tritium efflux from the two portions of the rat vas deferens in both experimental groups. The prostatic portion released a similar amount of 3H normetanephrine than the apididymal end, whereas other metabolic fractions (3,4-dihydroxyphenylglycol; 3,4-dihydroxymandelic acid and O-methylated deaminated metabolites) were smaller in the prostatic portion in comparison with the epididymal portion from control vas deferens. The results presented in the isolated rat vas deferens suggest the existence of a prostaglandin as well as an alpha adrenoceptive modulation of the spontaneous total tritium efflux. © 1981.

Registro:

Documento: Artículo
Título:3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens
Autor:Fernández Pardal, J.; Borda, E.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN) Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Rep, V. de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:acetylsalicylic acid; phenoxybenzamine; phentolamine; radioisotope; 3,4 dihydroxymandelic acid; 3,4 dihydroxyphenylethylene glycol; 3,4-dihydroxymandelic acid; 4 hydroxy 3 methoxyphenylethylene glycol; drug derivative; mandelic acid derivative; noradrenalin; animal experiment; drug metabolism; endocrine system; epididymis; male genital system; metabolism; noradrenalin h 3; prostate; rat; vas deferens; animal; article; castration; drug effect; epididymis; in vitro study; male; muscle contraction; prostate; rat strain; vas deferens; Animal; Castration; Epididymis; In Vitro; Male; Mandelic Acids; Methoxyhydroxyphenylglycol; Muscle Contraction; Norepinephrine; Prostate; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Vas Deferens
Año:1981
Volumen:29
Número:15
Página de inicio:1583
Página de fin:1589
DOI: http://dx.doi.org/10.1016/0024-3205(81)90260-5
Título revista:Life Sciences
Título revista abreviado:Life Sci.
ISSN:00243205
CODEN:LIFSA
CAS:acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; phenoxybenzamine, 59-96-1, 63-92-3; phentolamine, 50-60-2, 73-05-2; 3,4 dihydroxymandelic acid, 775-01-9; 3,4 dihydroxyphenylethylene glycol, 3343-19-9; 4 hydroxy 3 methoxyphenylethylene glycol, 534-82-7; noradrenalin, 1407-84-7, 51-41-2; 3,4-dihydroxymandelic acid, 775-01-9; dihydroxyphenylethylene glycol, 3343-19-9; Mandelic Acids; Methoxyhydroxyphenylglycol, 534-82-7; Norepinephrine, 51-41-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v29_n15_p1583_FernandezPardal

Referencias:

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Citas:

---------- APA ----------
Fernández Pardal, J., Borda, E., Gimeno, M.F. & Gimeno, A.L. (1981) . 3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens. Life Sciences, 29(15), 1583-1589.
http://dx.doi.org/10.1016/0024-3205(81)90260-5
---------- CHICAGO ----------
Fernández Pardal, J., Borda, E., Gimeno, M.F., Gimeno, A.L. "3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens" . Life Sciences 29, no. 15 (1981) : 1583-1589.
http://dx.doi.org/10.1016/0024-3205(81)90260-5
---------- MLA ----------
Fernández Pardal, J., Borda, E., Gimeno, M.F., Gimeno, A.L. "3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens" . Life Sciences, vol. 29, no. 15, 1981, pp. 1583-1589.
http://dx.doi.org/10.1016/0024-3205(81)90260-5
---------- VANCOUVER ----------
Fernández Pardal, J., Borda, E., Gimeno, M.F., Gimeno, A.L. 3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens. Life Sci. 1981;29(15):1583-1589.
http://dx.doi.org/10.1016/0024-3205(81)90260-5