Artículo
Fernández Pardal, J.; Gimeno, A.L.; Barrio, A. "Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons" (1980) Life Sciences. 26(21):1761-1764
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Abstract:
In the isolated rat tail artery preloaded with 3H-noradrenaline, neither acetylsalicyclic acid nor indomethacin modified the tritium release evoked by the Black Widow spider venom gland extract (BWGE), whereas clonidine diminished this effect of the venom. The data suggest that the BWGE process may operate in parallel with the prostaglandin mechanism and in series with the NA-mediated feed back pathway. It can not be excluded a prostaglandin interaction on the release process at a step prior to the point at which the venom acts. © 1980.
Registro:
| Documento: | Artículo |
| Título: | Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons |
| Autor: | Fernández Pardal, J.; Gimeno, A.L.; Barrio, A. |
| Filiación: | Centro Nacional de Investigaciones Iológicas (CENAI), Consejo Nacional de Investigaciones Cientificas y Tecnicas de La Republica Argentina (CONICET), Serrano 665, 1414 Buenos Aires, Argentina Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), CONICET, V. de Obligado 2490, 1428 Buenos Aires, Argentina |
| Palabras clave: | acetylsalicylic acid; clonidine; indometacin; noradrenalin; prostaglandin; radioisotope; spider venom; animal experiment; autonomic nervous system; drug release; in vitro study; noradrenalin h 3; peripheral vascular system; rat; sympathetic nerve; tail artery; Animal; Arthropod Venoms; Aspirin; Black Widow Spider; Catecholamines; Clonidine; In Vitro; Indomethacin; Male; Muscle, Smooth, Vascular; Neurons; Norepinephrine; Potassium; Prostaglandins; Rats; Spider Venoms; Sympathetic Nervous System |
| Año: | 1980 |
| Volumen: | 26 |
| Número: | 21 |
| Página de inicio: | 1761 |
| Página de fin: | 1764 |
| DOI: | http://dx.doi.org/10.1016/0024-3205(80)90575-5 |
| Título revista: | Life Sciences |
| Título revista abreviado: | Life Sci. |
| ISSN: | 00243205 |
| CODEN: | LIFSA |
| CAS: | acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; clonidine, 4205-90-7, 4205-91-8, 57066-25-8; indometacin, 53-86-1, 74252-25-8, 7681-54-1; noradrenalin, 1407-84-7, 51-41-2; Arthropod Venoms; Aspirin, 50-78-2; Catecholamines; Clonidine, 4205-90-7; Indomethacin, 53-86-1; Norepinephrine, 51-41-2; Potassium, 7440-09-7; Prostaglandins; Spider Venoms |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v26_n21_p1761_FernandezPardal |
Referencias:
- Fernandez Pardal, Granata, Barrio, (1979) Toxicon, 17, pp. 455-465
- Hedqvist, (1977) Ann. Rev. Pharmacol. Toxicol., 17, pp. 259-279
- Starke, (1977) Rev. Physiol. Biochem. Pharmacol., 77, pp. 1-124
- Snedecor, Cochran, (1967) Statistical methods, , 6th ed., The Iowa State University Press, Ames
- Starke, Altman, (1973) Neuropharmacology, 12, pp. 339-347
- Kirpekar, Puig, (1971) Br. J. Pharmac., 43, pp. 359-369
- Taube, Starke, Borowski, (1977) Naunyn-Schmiedebergers' Arch. Pharmac., 299, pp. 123-141
- Bergstrom, Farnebo, Fuxe, Effect of prostaglandin E2 on central and peripheral catecholamine neurons (1973) European Journal of Pharmacology, 21, pp. 362-368
- Stjarne, Kinetics of Secretion of Sympathetic Neurotransmitter as a Function of External Calcium: Mechanism of Inhibitory Effect of Prostaglandin E (1973) Acta Physiologica Scandinavica, 87, pp. 428-430
- Flower, (1974) Pharmacological Rev., 26, pp. 33-67
- Starke, Montel, (1973) J. Pharm. Pharmac., 25, pp. 758-759
Citas:
---------- APA ----------
Fernández Pardal, J., Gimeno, A.L. & Barrio, A. (1980) . Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons. Life Sciences, 26(21), 1761-1764.http://dx.doi.org/10.1016/0024-3205(80)90575-5
---------- CHICAGO ----------
Fernández Pardal, J., Gimeno, A.L., Barrio, A. "Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons" . Life Sciences 26, no. 21 (1980) : 1761-1764.http://dx.doi.org/10.1016/0024-3205(80)90575-5
---------- MLA ----------
Fernández Pardal, J., Gimeno, A.L., Barrio, A. "Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons" . Life Sciences, vol. 26, no. 21, 1980, pp. 1761-1764.http://dx.doi.org/10.1016/0024-3205(80)90575-5
---------- VANCOUVER ----------
Fernández Pardal, J., Gimeno, A.L., Barrio, A. Inhibitors of prostaglandins synthesis and the release of noradrenaline evoked by black widow spider venom gland extract in peripheral catecholamine neurons. Life Sci. 1980;26(21):1761-1764.http://dx.doi.org/10.1016/0024-3205(80)90575-5
