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Helguera, G.; Jemielity, S.; Abraham, J.; Cordo, S.M.; Martinez, M.G.; Rodríguez, J.A.; Bregni, C.; Wang, J.J.; Farzan, M.; Penichet, M.L.; Candurra, N.A.; Choe, H. "An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses" (2012) Journal of Virology. 86(7):4024-4028
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Abstract:

Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers. © 2012, American Society for Microbiology.

Registro:

Documento: Artículo
Título:An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
Autor:Helguera, G.; Jemielity, S.; Abraham, J.; Cordo, S.M.; Martinez, M.G.; Rodríguez, J.A.; Bregni, C.; Wang, J.J.; Farzan, M.; Penichet, M.L.; Candurra, N.A.; Choe, H.
Filiación:Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, MA, United States
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
The Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, United States
New England Primate Center, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, United States
Division of Surgical Oncology, Department of Surgery, Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States
Palabras clave:CD71 antigen; epitope; monoclonal antibody ch128.1; unclassified drug; virus glycoprotein; animal cell; Arenavirus; article; binding affinity; binding site; Chapare virus; controlled study; Guanarito virus; human; human cell; IC 50; Junin virus; Lassa virus; machupo arenavirus; nonhuman; nucleotide sequence; priority journal; Sabia virus; virus entry; virus replication; Amino Acid Sequence; Animals; Antibodies; Antigens, CD; Arenaviruses, New World; Cell Line; Down-Regulation; Hemorrhagic Fevers, Viral; Humans; Molecular Sequence Data; Protein Structure, Tertiary; Receptors, Transferrin; Receptors, Virus; Sequence Alignment; Virus Internalization; Arenavirus; Junin virus; New world arenaviruses
Año:2012
Volumen:86
Número:7
Página de inicio:4024
Página de fin:4028
DOI: http://dx.doi.org/10.1128/JVI.06397-11
Título revista:Journal of Virology
Título revista abreviado:J. Virol.
ISSN:0022538X
CODEN:JOVIA
CAS:Antibodies; Antigens, CD; CD71 antigen; Receptors, Transferrin; Receptors, Virus
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022538X_v86_n7_p4024_Helguera

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Citas:

---------- APA ----------
Helguera, G., Jemielity, S., Abraham, J., Cordo, S.M., Martinez, M.G., Rodríguez, J.A., Bregni, C.,..., Choe, H. (2012) . An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses. Journal of Virology, 86(7), 4024-4028.
http://dx.doi.org/10.1128/JVI.06397-11
---------- CHICAGO ----------
Helguera, G., Jemielity, S., Abraham, J., Cordo, S.M., Martinez, M.G., Rodríguez, J.A., et al. "An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses" . Journal of Virology 86, no. 7 (2012) : 4024-4028.
http://dx.doi.org/10.1128/JVI.06397-11
---------- MLA ----------
Helguera, G., Jemielity, S., Abraham, J., Cordo, S.M., Martinez, M.G., Rodríguez, J.A., et al. "An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses" . Journal of Virology, vol. 86, no. 7, 2012, pp. 4024-4028.
http://dx.doi.org/10.1128/JVI.06397-11
---------- VANCOUVER ----------
Helguera, G., Jemielity, S., Abraham, J., Cordo, S.M., Martinez, M.G., Rodríguez, J.A., et al. An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses. J. Virol. 2012;86(7):4024-4028.
http://dx.doi.org/10.1128/JVI.06397-11