Artículo

Serra, J.A.; Marschoff, E.R.; Domínguez, R.O.; Guareschi, E.M.; Famulari, A.L.; Pagano, M.A.; De Lustig, E.S.; Bartolomé, E.L.; González, S.; D'Abraccio, G.; Arata, M.; Oudkerk, L.; Garau, L.; Krinsky, F.; Labos, E.; Ruiz, C.; Frechtel, G.; Arana, A.; Lovecchio, S. "Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition" (2004) Journal of the Neurological Sciences. 218(1-2):17-24
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Abstract:

Oxidative stress is associated with Alzheimer's (DAT) and vascular (VD) dementias, as well as Type II diabetes mellitus (DIAB) and affected by hypoglycemic therapy. The population (n=122; males=60; mean age=72.57±7. 06) consisted of controls (CTR), DAT and VD patients, with (DAT+DIAB, VD+DIAB) and without concomitant DIAB, resulting in six groups where the antioxidant profile was determined: copper-zinc superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), and total antioxidant capacity (TRAP). The results were analyzed using a two-way ANOVA design and Bonferroni statistic. The ANOVAs yielded significant differences between groups for all components of the profile: SOD, p=0.00000006; TBARS, p=0.0000012; TRAP, p=0.0000003. The significance level for comparisons between groups was set at α=0.05. The comparisons DIAB vs. CTR, DAT+DIAB vs. DAT, and DIAB demented vs. DIAB non-demented resulted significant for all variables. VD+DIAB vs. VD resulted significant for all variables except TRAP. The antioxidant profiles of DIAB and CTR are different. The differences cannot be directly related with what is observed in dementias. The differences in profiles of demented and non-demented are somewhat hidden when demented patients are affected by a concomitant DIAB condition and/or hypoglycemic treatment, thus conditioning the diagnostic value for dementias of the profiles. © 2003 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition
Autor:Serra, J.A.; Marschoff, E.R.; Domínguez, R.O.; Guareschi, E.M.; Famulari, A.L.; Pagano, M.A.; De Lustig, E.S.; Bartolomé, E.L.; González, S.; D'Abraccio, G.; Arata, M.; Oudkerk, L.; Garau, L.; Krinsky, F.; Labos, E.; Ruiz, C.; Frechtel, G.; Arana, A.; Lovecchio, S.
Filiación:Consejo Nac. de Invest. Cie. y Tec., Argentina
Fac. de Ciencias Exactas y Naturales, UBA, Argentina
Hospital Sirio-Libanés, Facultad de Medicina, UBA, Buenos Aires, Argentina
Lab. Especializado para las Invest., Clínicas (LEPLIC), Buenos Aires, Argentina
Hospital Juan A. Fernández, Facultad de Medicina, UBA, Argentina
Inst. de Oncol. Angel H. Roffo, UBA, Argentina
Lab. Biomembranas y Canales Ionicos, Catedra Quim. Gen. e Inorg., Univ. de Buenos Aires, Junín 954, Buenos Aires (1113), Argentina
Diabetes Unit, Hosp. Gen. Agudos Juan A. Fernandez, Hospital Sirio-Libanés, Argentina
Cátedra Biometría, Depto. Ciencias Biológicas, Ciudad Universitaria, Avda. Intendente Guiraldes s/n, Buenos Aires (1428), Argentina
Hospital Sirio-Libanés, Cátedra de Neurología, Fund. Argentina Contra E., Campana 4658, Buenos Aires (1419), Argentina
Lab. Especializado Invest. C., Buenos Aires (1121), Argentina
Hospital Sirio-Libanés, Fund. Argentina Contra E., Campana 4658, Buenos Aires (1419), Argentina
Hosp. Gen. Agudos Juan A. Fernandez, Cátedra de Neurología, Fund. Argentina Contra E., Buenos Aires (1117), Argentina
Departamento Investigación, Inst. de Oncol. Angel H. Roffo, Univ. de Buenos Aires, Avda. San Martín 5481, Buenos Aires (1417), Argentina
Palabras clave:Antioxidant profiles; Non-insulin-dependent Type II diabetes mellitus; Oxidative stress; Probable dementia of the Alzheimer's type; Sulfonylureas; Vascular dementia; alpha glucosidase inhibitor; antidiabetic agent; antioxidant; biguanide; copper zinc superoxide dismutase; glibenclamide; gliclazide; glimepiride; sulfonylurea derivative; thiobarbituric acid reactive substance; adult; aged; Alzheimer disease; analysis of variance; antioxidant activity; article; comorbidity; controlled study; dementia; diagnostic value; female; human; major clinical study; male; multiinfarct dementia; non insulin dependent diabetes mellitus; oxidative stress; priority journal; quantitative analysis; statistical analysis
Año:2004
Volumen:218
Número:1-2
Página de inicio:17
Página de fin:24
DOI: http://dx.doi.org/10.1016/j.jns.2003.10.004
Título revista:Journal of the Neurological Sciences
Título revista abreviado:J. Neurol. Sci.
ISSN:0022510X
CODEN:JNSCA
CAS:biguanide, 56-03-1; copper zinc superoxide dismutase, 149394-67-2; glibenclamide, 10238-21-8; gliclazide, 21187-98-4; glimepiride, 93479-97-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022510X_v218_n1-2_p17_Serra

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Citas:

---------- APA ----------
Serra, J.A., Marschoff, E.R., Domínguez, R.O., Guareschi, E.M., Famulari, A.L., Pagano, M.A., De Lustig, E.S.,..., Lovecchio, S. (2004) . Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition. Journal of the Neurological Sciences, 218(1-2), 17-24.
http://dx.doi.org/10.1016/j.jns.2003.10.004
---------- CHICAGO ----------
Serra, J.A., Marschoff, E.R., Domínguez, R.O., Guareschi, E.M., Famulari, A.L., Pagano, M.A., et al. "Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition" . Journal of the Neurological Sciences 218, no. 1-2 (2004) : 17-24.
http://dx.doi.org/10.1016/j.jns.2003.10.004
---------- MLA ----------
Serra, J.A., Marschoff, E.R., Domínguez, R.O., Guareschi, E.M., Famulari, A.L., Pagano, M.A., et al. "Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition" . Journal of the Neurological Sciences, vol. 218, no. 1-2, 2004, pp. 17-24.
http://dx.doi.org/10.1016/j.jns.2003.10.004
---------- VANCOUVER ----------
Serra, J.A., Marschoff, E.R., Domínguez, R.O., Guareschi, E.M., Famulari, A.L., Pagano, M.A., et al. Oxidative stress in Alzheimer's and vascular dementias: Masking of the antioxidant profiles by a concomitant Type II diabetes mellitus condition. J. Neurol. Sci. 2004;218(1-2):17-24.
http://dx.doi.org/10.1016/j.jns.2003.10.004