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Abstract:

The binding of [1, 2, 6, 7-3H]-corticosterone was studied in brain cytosol from normal and streptozotocin-diabetic male rats. The experiments were performed under conditions of incubation time (4h), temperature (0-4°C), time after adrenalectomy (6 days) and corticosterone concentrations (1.2 × 10-8 and 1.15 × 10-9M) previously established for determining binding activity in the brain of normal rats. The binding of [3H]-corticosterone was found invariably lower in cytosol of the brain from diabetic rats, studied under three different conditions: in non-adrenalectomized animals, in adrenalectomized using a non-saturating corticosterone concentration, and in adrenalectomized plus a saturating steroid concentration. These results support previous contentions that the diminished sensitivity to the negative feedback for steroids which is present in diabetics, may be related to a reduction in binding capacity for corticoids in the central nervous system. © 1978.

Registro:

Documento: Artículo
Título:Reduction in [3H]-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats
Autor:Fridman, O.; Foglia, V.G.; De Nlcola, A.F.
Filiación:Laboratorio de Esteroides, Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:aldosterone; corticosterone; glucocorticoid receptor; steroid receptor; drug receptor; hormone receptor; radioisotope; streptozocin; adrenalectomy; animal; article; binding competition; brain; cytosol; experimental diabetes mellitus; kinetics; male; metabolism; rat; temperature; adrenalectomy; aldosterone h 3; animal experiment; brain; central nervous system; corticosterone h 3; cytoplasm; cytosol; diabetes mellitus; endocrine system; rat; Adrenalectomy; Aldosterone; Animal; Binding, Competitive; Brain; Corticosterone; Cytosol; Diabetes Mellitus, Experimental; Kinetics; Male; Rats; Receptors, Glucocorticoid; Receptors, Steroid; Temperature
Año:1978
Volumen:9
Número:7
Página de inicio:609
Página de fin:614
DOI: http://dx.doi.org/10.1016/0022-4731(78)90171-1
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:aldosterone, 52-39-1, 6251-69-0; corticosterone, 50-22-6; streptozocin, 18883-66-4; Aldosterone, 52-39-1; Corticosterone, 50-22-6; Receptors, Glucocorticoid; Receptors, Steroid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v9_n7_p609_Fridman

Referencias:

  • Domínguez, Chieri, Foglia, Acta physiol. latinoamer (1969) Adrenal corticosterone content and adrenal vein blood corticosterone level in experimental diabetes, 19, pp. 196-201
  • Devecerski, Frawley, Adrenal steroid production in rats with alloxan diabetes (1963) Endocrinology, 73, pp. 386-391
  • Naeser, Structure and function of the adrenal cortex in mice with the obese-hyperglycemic syndrome (1974) Acta Univ. Upsaliensis, 186, pp. 1-20
  • L'Age, Langholz, Fechner, Salszman, Disturbances of the hypothalamo-hypophysial-adrenocortical system in the alloxan diabetic rat (1974) Endocrinology, 95, pp. 760-765
  • De Nicola, Fridman, Del Castillo, Foglia, The influence of Streptozotocin diabetes on adrenal function in male rats (1976) Horm. Metab. Res., 8, pp. 388-392
  • De Nicola, Fridman, Del Castillo, Foglia, Abnormal regulation of adrenal function in rats with Streptozotocin diabetes (1977) Horm. Metab. Res., 9, pp. 469-473
  • McEwen, Wallach, Corticosterone binding to hippocampus: nuclear and cytosol binding in vitro (1973) Brain Res., 57, pp. 373-386
  • Grosser, Stevens, Reed, Properties of corticosterone binding macromolecules from rat brain cytosol (1973) Brain Res., 57, pp. 387-395
  • Cake, Litwack, The glucocorticoid receptor (1975) Biochemical Actions of Hormones, 3, pp. 317-390. , G. Litwack, Academic Press, New York
  • Junod, Lambert, Orci, Pictet, Gonet, Renold, Studies of the diabetogenic action of Streptozotocin (1967) Proc. Soc. expl. Biol. Med., 126, pp. 201-205
  • Somogyi, Notes on sugar determination (1952) J. biol. Chem., 195, pp. 19-23
  • Lassman, Mulrow, Deficiency of deoxycorticosterone-binding protein in the hypothalamus of rats resistant to deoxycorticosterone-induced hypertension (1974) Endocrinology, 94, pp. 1541-1546
  • Baxter, Tomkins, Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells (1971) Proc. natn. Acad. Sci. (Wash), 68, pp. 932-937
  • Lowry, Rosenbrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Koch, Lutz, Briand, Mialhe, Heterogeneity of pituitary glucocorticoid binding. Evidence for a transcortin-like compound (1976) Biochim. biophys. Acta, 444, pp. 497-507
  • Ballard, Baxter, Higgins, Rousseau, Tomkins, General presence of glucocorticoid receptors in mammalian tissues (1974) Endocrinology, 94, pp. 998-1002
  • Venning, Adenohypophysis and adrenal cortex (1965) Ann. Rev. Physiol., 27, pp. 107-132
  • McEwen, Interactions between hormones and nerve tissue (1976) Sci. Am., 235, pp. 48-58
  • Nelson, Regulation of glucocorticoid release (1972) Am. J. Med., 53, pp. 590-594
  • De Nicola, Oliver, Birmingham, Biotransformation of [1,2-3H]-deoxycorticosterone and [4-14C]-progesterone by rats with adrenal regeneration hypertension (1968) Endocrinology, 83, pp. 141-148
  • De Nicola, Dahl, Kaplan, Transformation of [14C]-pregnenolone and production of corticosteroids by adrenal glands from rats bearing a transplantable mammotropic pituitary tumor (1973) J. steroid Biochem., 4, pp. 205-215
  • Denari, Rosner, Sexual steroid uptake in the alloxanized diabetic rat (1972) Steroids Lipid Res., 3, pp. 151-155
  • Naess, Haug, Attramadal, Aakvaag, Hansson, French, Androgen receptors in the anterior pituitary and central nervous system of the androgen “insensitive” (Tfm) rat: correlation between receptor binding and effects of androgen on gonadotropin secretion (1976) Endocrinology, 99, pp. 1295-1303

Citas:

---------- APA ----------
Fridman, O., Foglia, V.G. & De Nlcola, A.F. (1978) . Reduction in [3H]-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats. Journal of Steroid Biochemistry, 9(7), 609-614.
http://dx.doi.org/10.1016/0022-4731(78)90171-1
---------- CHICAGO ----------
Fridman, O., Foglia, V.G., De Nlcola, A.F. "Reduction in [3H]-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats" . Journal of Steroid Biochemistry 9, no. 7 (1978) : 609-614.
http://dx.doi.org/10.1016/0022-4731(78)90171-1
---------- MLA ----------
Fridman, O., Foglia, V.G., De Nlcola, A.F. "Reduction in [3H]-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats" . Journal of Steroid Biochemistry, vol. 9, no. 7, 1978, pp. 609-614.
http://dx.doi.org/10.1016/0022-4731(78)90171-1
---------- VANCOUVER ----------
Fridman, O., Foglia, V.G., De Nlcola, A.F. Reduction in [3H]-corticosterone binding to cytoplasmic receptors in the brain of diabetic rats. J. Steroid Biochem. 1978;9(7):609-614.
http://dx.doi.org/10.1016/0022-4731(78)90171-1