Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The formation of various compounds upon reaction of 18 hydroxycorticosterone with neutral and acid-added alcohols as well as with acidic aqueous solutions is described. The time course of their formation in such media has been studied. Some of these compounds have been isolated and tentatively identified by paper chromatography employing double isotope techniques and by mass spectrometry. The more polar form has a C-20 hemiketalic structure; the single less polar form obtained upon storage in neutral methanol would be the methylketal at C-20 but the less polar fraction having the same mobility in the Chromatographie system employed, obtained upon reaction with acidic aqueous solutions, seems to be formed by two different dehydration products. © 1978.

Registro:

Documento: Artículo
Título:Less polar forms and derivatives of 18 hydroxy-corticosterone
Autor:Aragones, A.; Gros, E.G.; Lantos, C.P.; Locascio, G.A.
Filiación:Laboratorio de Esteroides, Departamento de Química Biológica, Argentina
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon 2, Giudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:18 hydroxycorticosterone derivative; endocrine system; 18-Hydroxycorticosterone; Butanols; Chemistry; Corticosterone; Ethanol; Hydrochloric Acid; Methanol; Spectrum Analysis, Mass; Water
Año:1978
Volumen:9
Número:2
Página de inicio:175
Página de fin:180
DOI: http://dx.doi.org/10.1016/0022-4731(78)90081-X
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:18-Hydroxycorticosterone, 561-65-9; Butanols; Corticosterone, 50-22-6; Ethanol, 64-17-5; Hydrochloric Acid, 7647-01-0; Methanol, 67-56-1; Water, 7732-18-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v9_n2_p175_Aragones

Referencias:

  • Péron, (1960) Endocrinology, 66, pp. 458-474
  • Dominguez, (1965) Steroids Suppl., 2, pp. 29-49
  • Levy, Cargill, Cha, Hood, Carlo, (1965) Steroids, 5, pp. 131-146
  • Kirk, Rajagopalan, A synthesis of 11?,18,21-trihydroxypregn-4-ene-3,20-dione (?18-hydroxy-corticosterone?) (1976) Journal of the Chemical Society, Chemical Communications, pp. 77-78
  • Damasco, Lantos, (1975) J. steroid Biochem., 6, pp. 69-74
  • Sandor, Lanthier, (1963) Acta endocr., Copenh., 42, pp. 355-363
  • Raman, Ertel, Ungar, (1964) Endocrinology, 74, pp. 865-869
  • Roy, Ramirez, Ulick, (1976) J. steroid Biochem., 7, pp. 81-87
  • Génard, Palem-Vliers, Denoel, Van Cauwenberge, Eechauten, (1975) J. steroid Biochem., 6, pp. 201-210
  • Damasco, Diaz, Lantos, (1976) Gen. comp. Endocr., 29 (2). , Abstract 124
  • Bush, (1952) Biochem. J., 50, pp. 370-378
  • Aragonés A., Lantos C. P. and Locascio G. A.: Acta physiol. Latinoam. (in press); Kondo, Mitsugi, Tori, Microbiological Synthesis of Aldosterone from Corticosterone (1966) Journal of the American Chemical Society, 87, pp. 4655-4656
  • Schmidlin, Wettstein, Synthese Aldosteron-�hnlicher Corticosteroide.d,l-18-Hydroxycorticosteron undd,l-18-Desoxyaldosteron (1961) Helvetica Chimica Acta, 44, pp. 1596-1607
  • Schmidlin, Wettstein, �ber 11,18-dioxygenierte Progesterone. �ber Steroide, 161. Mitteilung (1959) Helvetica Chimica Acta, 42, pp. 2636-2645
  • Tori, Tomita, Itazaki, Narisada, Nagata, (1963) Chem. Pharm. Bull (Japan), 11, pp. 956-959

Citas:

---------- APA ----------
Aragones, A., Gros, E.G., Lantos, C.P. & Locascio, G.A. (1978) . Less polar forms and derivatives of 18 hydroxy-corticosterone. Journal of Steroid Biochemistry, 9(2), 175-180.
http://dx.doi.org/10.1016/0022-4731(78)90081-X
---------- CHICAGO ----------
Aragones, A., Gros, E.G., Lantos, C.P., Locascio, G.A. "Less polar forms and derivatives of 18 hydroxy-corticosterone" . Journal of Steroid Biochemistry 9, no. 2 (1978) : 175-180.
http://dx.doi.org/10.1016/0022-4731(78)90081-X
---------- MLA ----------
Aragones, A., Gros, E.G., Lantos, C.P., Locascio, G.A. "Less polar forms and derivatives of 18 hydroxy-corticosterone" . Journal of Steroid Biochemistry, vol. 9, no. 2, 1978, pp. 175-180.
http://dx.doi.org/10.1016/0022-4731(78)90081-X
---------- VANCOUVER ----------
Aragones, A., Gros, E.G., Lantos, C.P., Locascio, G.A. Less polar forms and derivatives of 18 hydroxy-corticosterone. J. Steroid Biochem. 1978;9(2):175-180.
http://dx.doi.org/10.1016/0022-4731(78)90081-X