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Abstract:

18-Hydroxycorticosterone exhibits a spontaneous interconversion between two forms separable by paper chromatography, a and b. Upon acetylation, both give rise to at least one compound having identical chromatographic properties irrespective of the basic form utilized. Both forms present different chromatographic patterns upon elution from Sephadex LH 20. The less polar on paper strips (a) also migrated closer to the solvent front after gel filtration. In repeated experiments, a proved to be a better precursor for aldosterone-like material than b. In at least one case, these results could be confirmed for purified aldosterone. Also, the uptake of a by adrenal tissue is higher than that of b. © 1975.

Registro:

Documento: Artículo
Título:The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?
Autor:Damasco, M.C.; Lantos, C.P.
Filiación:Laboratorio de Esteroides, Departamento de Quimica Biológica, Facultad de Ciencias Exaetas y Naturales, Buenos Aires, Argentina
Instituto Antártico Argentine, Buenos Aires, Argentina
Palabras clave:18 hydroxycorticosterone; aldosterone; hydroxycorticosteroid; radioisotope; steroid hormone; 18 hydroxyprogesterone; adrenal gland; aldosterone c 14; corticosterone h 3; drug absorption; drug metabolism; formyl synthetase; paper chromatography; pharmacokinetics; rat; theoretical study; 18-Hydroxycorticosterone; Acetylation; Adrenal Glands; Aldosterone; Animal; Carbon Radioisotopes; Chromatography, Gel; Chromatography, Paper; Corticosterone; Male; Rats; Solvents; Time Factors; Tritium
Año:1975
Volumen:6
Número:1
Página de inicio:69
Página de fin:74
DOI: http://dx.doi.org/10.1016/0022-4731(75)90031-X
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:18 hydroxycorticosterone, 561-65-9; aldosterone, 52-39-1, 6251-69-0; 18-Hydroxycorticosterone, 561-65-9; Aldosterone, 52-39-1; Carbon Radioisotopes; Corticosterone, 50-22-6; Solvents; Tritium, 10028-17-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v6_n1_p69_Damasco

Referencias:

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  • Pasqualini, (1964) Nature, 201, p. 501
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Citas:

---------- APA ----------
Damasco, M.C. & Lantos, C.P. (1975) . The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?. Journal of Steroid Biochemistry, 6(1), 69-74.
http://dx.doi.org/10.1016/0022-4731(75)90031-X
---------- CHICAGO ----------
Damasco, M.C., Lantos, C.P. "The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?" . Journal of Steroid Biochemistry 6, no. 1 (1975) : 69-74.
http://dx.doi.org/10.1016/0022-4731(75)90031-X
---------- MLA ----------
Damasco, M.C., Lantos, C.P. "The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?" . Journal of Steroid Biochemistry, vol. 6, no. 1, 1975, pp. 69-74.
http://dx.doi.org/10.1016/0022-4731(75)90031-X
---------- VANCOUVER ----------
Damasco, M.C., Lantos, C.P. The existence of two interconvertible forms of 18-hydroxycorticosterone: Is one of them an active pŕecursor of aldosterone?. J. Steroid Biochem. 1975;6(1):69-74.
http://dx.doi.org/10.1016/0022-4731(75)90031-X