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Abstract:

The metabolism of [3H]-testosterone in perfused dog adrenals and in adrenal minces of a normal dog has been studied. Three principal metabolites were studied and identified by isotope dilution and gas-liquid chromatography-mass speetrometry: androstenedione, 11β-hydroxyandrostenedione and 11 β-hydroxytestosterone. The last of these metabolites is obtained in high yield which is further increased after ACTH administration. © 1973.

Registro:

Documento: Artículo
Título:Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth
Autor:Wassermann, G.F.; Baldi, A.; del Castillo, E.; Charreau, E.
Filiación:Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Obligado 2490 Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:androstane derivative; androstenedione; corticosteroid; corticotropin; hydroxysteroid; oxosteroid; testosterone; tritium; adrenal gland; animal; article; biosynthesis; blood; crystallization; dog; drug effect; gas chromatography; hypophysectomy; hypophysis; in vitro study; male; mass spectrometry; metabolism; perfusion; physiology; thin layer chromatography; Adrenal Cortex Hormones; Adrenal Glands; Androstenedione; Androstenes; Animal; Chromatography, Gas; Chromatography, Thin Layer; Corticotropin; Crystallization; Dogs; Hydroxysteroids; Hypophysectomy; In Vitro; Ketosteroids; Male; Perfusion; Pituitary Gland; Spectrum Analysis, Mass; Testosterone; Tritium
Año:1973
Volumen:4
Número:2
Página de inicio:217
Página de fin:226
DOI: http://dx.doi.org/10.1016/0022-4731(73)90027-7
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:androstenedione, 26264-53-9, 63-05-8; corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; testosterone, 58-22-0; tritium, 10028-17-8; Adrenal Cortex Hormones; Androstenedione, 63-05-8; Androstenes; Corticotropin, 9002-60-2; Hydroxysteroids; Ketosteroids; Testosterone, 57-85-2; Tritium, 10028-17-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v4_n2_p217_Wassermann

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Citas:

---------- APA ----------
Wassermann, G.F., Baldi, A., del Castillo, E. & Charreau, E. (1973) . Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth. Journal of Steroid Biochemistry, 4(2), 217-226.
http://dx.doi.org/10.1016/0022-4731(73)90027-7
---------- CHICAGO ----------
Wassermann, G.F., Baldi, A., del Castillo, E., Charreau, E. "Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth" . Journal of Steroid Biochemistry 4, no. 2 (1973) : 217-226.
http://dx.doi.org/10.1016/0022-4731(73)90027-7
---------- MLA ----------
Wassermann, G.F., Baldi, A., del Castillo, E., Charreau, E. "Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth" . Journal of Steroid Biochemistry, vol. 4, no. 2, 1973, pp. 217-226.
http://dx.doi.org/10.1016/0022-4731(73)90027-7
---------- VANCOUVER ----------
Wassermann, G.F., Baldi, A., del Castillo, E., Charreau, E. Metabolism of [3H]-testosterone by the adranal of the dog: The action of acth. J. Steroid Biochem. 1973;4(2):217-226.
http://dx.doi.org/10.1016/0022-4731(73)90027-7