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Abstract:

The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly derived from the cholesterol side chain without the compound's prior conversion into pregnenolone. The probable sequence in which the different bufadienolides are formed is discussed. © 1972.

Registro:

Documento: Artículo
Título:Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
Autor:Porto, A.M.; Baralle, F.E.; Gros, E.G.
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires. Pab. 2, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:bufadienolide derivative; carbon; cholesterol; mevalonic acid; pregnenolone; venom; animal; article; biosynthesis; gallbladder; metabolism; season; toad; Animal; Bufanolides; Bufonidae; Carbon Isotopes; Cholesterol; Gallbladder; Mevalonic Acid; Pregnenolone; Seasons; Venoms
Año:1972
Volumen:3
Número:1
Página de inicio:11
Página de fin:17
DOI: http://dx.doi.org/10.1016/0022-4731(72)90006-4
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:carbon, 7440-44-0; cholesterol, 57-88-5; mevalonic acid, 150-97-0; pregnenolone, 145-13-1; Bufanolides; Carbon Isotopes; Cholesterol, 57-88-5; Mevalonic Acid, 150-97-0; Pregnenolone, 145-13-1; Venoms
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v3_n1_p11_Porto

Referencias:

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Citas:

---------- APA ----------
Porto, A.M., Baralle, F.E. & Gros, E.G. (1972) . Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol. Journal of Steroid Biochemistry, 3(1), 11-17.
http://dx.doi.org/10.1016/0022-4731(72)90006-4
---------- CHICAGO ----------
Porto, A.M., Baralle, F.E., Gros, E.G. "Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol" . Journal of Steroid Biochemistry 3, no. 1 (1972) : 11-17.
http://dx.doi.org/10.1016/0022-4731(72)90006-4
---------- MLA ----------
Porto, A.M., Baralle, F.E., Gros, E.G. "Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol" . Journal of Steroid Biochemistry, vol. 3, no. 1, 1972, pp. 11-17.
http://dx.doi.org/10.1016/0022-4731(72)90006-4
---------- VANCOUVER ----------
Porto, A.M., Baralle, F.E., Gros, E.G. Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol. J. Steroid Biochem. 1972;3(1):11-17.
http://dx.doi.org/10.1016/0022-4731(72)90006-4