Artículo
Cozza, E.N.; Ceballos, N.R.; Lantos, C.P. "Effects of ACTH on the last step of aldosterone biosynthesis" (1989) Journal of Steroid Biochemistry. 33(6):1253-1255
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Abstract:
The production of tritiated aldosterone and tritiated SM (a saponifiable 18-hydroxycorticosterone derivative) by rat adrenals were studied at various incubation times in absence or presence of two concentrations of ACTH. Tritiated 18-hydroxycorticosterone or 18-deoxyaldosterone served as precursors. The lower ACTH concentration (150 pM) increased the production of tritiated aldosterone. Whereas, the higher ACTH concentration (1.5 μM) stimulated tritiated aldosterone production at shorter incubation time (30 min), while after 60 min it inhibited. This time dependency would reflect variations in the levels of endogenous steroids. On the other hand, the effects of ACTH on tritiated SM production were opposite to those on tritiated aldosterone. In effect, while 150 pM ACTH inhibited SM production, 1.5 μM ACTH stimulated it. These results suggest that ACTH promotes opposite effects on the productions of aldosterone and SM and therefore both productions would be coordinated under the regulation of ACTH. © 1989.
Registro:
| Documento: | Artículo |
| Título: | Effects of ACTH on the last step of aldosterone biosynthesis |
| Autor: | Cozza, E.N.; Ceballos, N.R.; Lantos, C.P. |
| Filiación: | Laboratorio de Esteroides, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Programa de Regulatión Hormonal y Metabólica, CONICET, Buenos Aires, Argentina |
| Palabras clave: | 18 hydroxycorticosterone; aldosterone; corticotropin; radioisotope; adrenal gland; animal cell; article; nonhuman; priority journal; rat; Adrenal Glands; Aldosterone; Animal; Corticotropin; Male; Mitochondria; Rats; Support, Non-U.S. Gov't; Animalia |
| Año: | 1989 |
| Volumen: | 33 |
| Número: | 6 |
| Página de inicio: | 1253 |
| Página de fin: | 1255 |
| DOI: | http://dx.doi.org/10.1016/0022-4731(89)90438-X |
| Título revista: | Journal of Steroid Biochemistry |
| Título revista abreviado: | J. Steroid Biochem. |
| ISSN: | 00224731 |
| CODEN: | JSTBB |
| CAS: | 18-deoxyaldosterone, 2507-88-2; Aldosterone, 52-39-1; Corticotropin, 9002-60-2 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v33_n6_p1253_Cozza |
Referencias:
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- Ulick S.: Normal and alternative pathways in aldosterone biosynthesis. In Proceeding of the 4th Int. Congress of Endocrinology (Edited by R. O. Scow) Elsevier, New York p. 761; Della-Cioppa, Muffly, Yanagibashi, Hall, Preparation and characterization of submitochondrial fractions from adrenal cells (1986) Molec. Cell Endocr., 48, pp. 111-120
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Citas:
---------- APA ----------
Cozza, E.N., Ceballos, N.R. & Lantos, C.P. (1989) . Effects of ACTH on the last step of aldosterone biosynthesis. Journal of Steroid Biochemistry, 33(6), 1253-1255.http://dx.doi.org/10.1016/0022-4731(89)90438-X
---------- CHICAGO ----------
Cozza, E.N., Ceballos, N.R., Lantos, C.P. "Effects of ACTH on the last step of aldosterone biosynthesis" . Journal of Steroid Biochemistry 33, no. 6 (1989) : 1253-1255.http://dx.doi.org/10.1016/0022-4731(89)90438-X
---------- MLA ----------
Cozza, E.N., Ceballos, N.R., Lantos, C.P. "Effects of ACTH on the last step of aldosterone biosynthesis" . Journal of Steroid Biochemistry, vol. 33, no. 6, 1989, pp. 1253-1255.http://dx.doi.org/10.1016/0022-4731(89)90438-X
---------- VANCOUVER ----------
Cozza, E.N., Ceballos, N.R., Lantos, C.P. Effects of ACTH on the last step of aldosterone biosynthesis. J. Steroid Biochem. 1989;33(6):1253-1255.http://dx.doi.org/10.1016/0022-4731(89)90438-X
