Navegar

Colección

Datos Estadísticas

Artículo

Lantos, C.P.; Damasco, M.C.; Aragonés, A.; Ceballos, N.R.; Burton, G.; Cozza, E.N. "Versatile steroid molecules at the end of the aldosterone pathway" (1987) Journal of Steroid Biochemistry. 27(4-6):791-800
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

18-hydroxycorticosterone converts spontaneously and reversibly to a variety of less polar forms and derivatives, some of which are precursors to aldosterone. In particular, 21-hydroxy-11β,18-oxido-4-pregnene-3,20-dione (18-DAL) is hydroxylated to aldosterone with high yields in the presence of malate and NADP+ at pH 4.8.18-DAL also behaves as a metabolic intermediate between 18-OH-B and aldosterone accorcling to time-course and trapping experiments. Consequently, the final steps of the aldosterone pathway at pH 4.8 could be identified as 18-OH-B,18-DAL and aldosterone, in this sequence. The submitochondrial distribution of aldosterone biosynthesis is compatible with this postulate. The work also shows that some forms of 18-OH-B are promoters of hydrogen transport in renal tubuli and that this regulation may be independent of sodium reabsorption. These results suggest a regulatory model, new in steroid biology, accorcling to which steroid molecules bearing an oxidized angular C18-methyl may undergo structural changes between precursor ("P") and hormonal ("H") forms in response to homeostatic requirements. © 1987.

Registro:

Documento: Artículo
Título:Versatile steroid molecules at the end of the aldosterone pathway
Autor:Lantos, C.P.; Damasco, M.C.; Aragonés, A.; Ceballos, N.R.; Burton, G.; Cozza, E.N.
Filiación:Laboratorio de Esteroides, Departamento de Qui'mica Biológica, PRHOM-CONICET, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina
Departamento de Química Orgánica, UMYMFOR-CONICET, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon 2, 1428 Buenos Aires, Argentina
Palabras clave:aldosterone; hormone precursor; reduced nicotinamide adenine dinucleotide phosphate; cattle; metabolism; mitochondrion; nonhuman; short survey; 18-Hydroxycorticosterone; Acid-Base Equilibrium; Adrenal Cortex; Aldosterone; Animal; Chemistry; Homeostasis; Hydrogen-Ion Concentration; Protein Precursors; Steroids
Año:1987
Volumen:27
Número:4-6
Página de inicio:791
Página de fin:800
DOI: http://dx.doi.org/10.1016/0022-4731(87)90151-8
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:aldosterone, 52-39-1, 6251-69-0; reduced nicotinamide adenine dinucleotide phosphate, 53-57-6; 18-deoxyaldosterone, 2507-88-2; 18-Hydroxycorticosterone, 561-65-9; Aldosterone, 52-39-1; Protein Precursors; Steroids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v27_n4-6_p791_Lantos

Referencias:

  • Neher, Aldosterone chemical aspects and related enzymology (1979) J Endocrinol, 81, pp. 25P-35P
  • Müller, (1971) Regulation of Aldosterone Biosynthesis, , Springer, Heidelberg
  • Vinson, Whitehouse, The biosynthesis and secretion of aldosterone by the rat zona glomerulosa and the significance of the compartmental arrangement of steroids (1973) Acta endocr., Copenh., 72, pp. 52-76
  • Vecsei, Lommer, Wolff, The intermediate role of 18-hydroxycorticosteroids in aldosterone biosynthesis (1968) Experientia, 24, pp. 1199-1201
  • Kojima, Inano, Tamaoki, The final step of aldosterone biosynthesis is catalized by an NADPH-dependent and molecular oxygen-requiring enzyme (1982) Biochem. biophys. Res. Commun., 106, pp. 617-624
  • Raman, Sharma, Dorfman, Gabrilove, Biosynthesis of C-18-oxygenated steroids by an aldosterone-secreting human adrenal tumor. Metabolism of (4-14C) progesterone, (1,2-3H) 11-deoxycorticosterone and (4-14C) pregnenolone (1965) Biochemistry, 4, pp. 1376-1385
  • Dominguez, The presence of two interconvertible forms of 18-hydroxy-11-deoxycorticosterone (1965) Steroids, pp. 29-49
  • Genard, The proton magnetic resonance spectra of d-aldosterone and its acetylated derivatives (1971) Organic Magnetic Resonance, 3, pp. 759-766
  • Borruel, Borruel, Damasco, Lantos, The investigation of four radioactive steroids in the Antartic Seal (Leptonychotes weddellii) (1974) Gen. comp. Endocr., 22, pp. 1-12
  • Llaurado, Identification of two C18 oxygenated corticosteroids isolated from human urine (1962) J. biol. Chem., 237, pp. 3364-3374. , quoted by Ulick S. and Kusch-Vetter K.:
  • Damasco, Lantos, The existence of two interconvertible forms of 18-hydroxycorticosterone is one of them the active precursor of aldosterone? (1975) J. steroid Biochem., 6, pp. 69-74
  • Kondo, Mitsugi, Tori, Microbiological synthesis of aldosterone from corticosterone (1965) J. Am. chem. Soc., 87, pp. 4655-4656
  • Kirk, A synthesis of 111821-trihydroxypregn-4-ene-320-dione (“18-Hydroxy-corticosterone”) (1976) Journal of the Chemical Society, Chemical Communications, pp. 77-78
  • Aragonés, Gros, Lantos, Locascio, Less polar forms and derivatives of 18-hydroxycorticosterone (1978) J. steroid Biochem., 9, pp. 175-180
  • Cozza, Burton, Ceballos, Lantos, Harnik, Scott, Eighteen-deoxyaldosterone and other less polar forms of 18-hydroxycorticosterone as aldosterone precursors in rat adrenals (1985) J. steroid Biochem., 22, pp. 665-672
  • Ulick, Normal and alternate pathways in aldosterone biosynthesis (1973) Proc. Fourth Int. Congr. Endocr., pp. 761-767. , Robert O. Scow, American Elsevier, New York
  • Finkelstein, Shaeller, Inborn errors of steroid biosynthesis (1979) Physiol. Rev., 59, pp. 353-406
  • Muller, The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: evidence for an alternative biosynthetic pathway (1980) J. steroid Biochem., 13, pp. 245-251
  • Aragonés, Lantos, Locascio, Spontaneous conversions to aldosterone (1976) Acta Physiol Lat Am, 26, pp. 277-282
  • Marusic, White, Aedo, Oxidative reactions in the formation of an aldehyde group in the biosynthesis of aldosterone (1973) Archs biochem. Biophys., 157, pp. 320-321
  • Aupetit, Accarie, Emeric, Vonrax, Legrand, The final step of aldosterone biosynthesis requires reducing power, it is not a dehydrogenation (1983) Biochem. biophys. Acta, 752, pp. 73-78
  • Kojima, Inano, Tamaoki, The final step of aldosterone biosynthesis is catalized by an NADPH-dependent and molecular oxygen-requiring enzyme (1982) Biochem. biophys. Res. Commun., 106, pp. 617-624
  • Ulick, Gautier, Vetter, Markello, Yaffe, Lowe, An aldosterone biosynthesis defect in salt-losing disorder (1964) J. clin. Endocr. Metab., 24, pp. 669-672
  • Wade, Okanido, Yonaka, Yamano, Aldosterone biosynthesis by a reconstituted cytochrome P-450 system (1984) Biochemical and Biophysical Research Communications, 119, p. 365
  • Reijngoud, Tager, The permeability properties of the lysosomal membrane (1977) Biochem. biophys. Acta, 472, pp. 419-449
  • Xiao-Song, Stone, Racker, Determinants of clathrin-coated vesicle acidification (1983) J. biol. Chem., 258, pp. 14,834-14,838
  • Psychoyos, Tallan, Greengard, Aldosterone synthesis by adrenal mitochondria (1966) J. biol. Chem., 241, pp. 2949-2956
  • Mitchell, Moyle, Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria (1969) eur. J. Biochem., 7, pp. 471-484
  • Schnaitman, Greenwalt, Enzymatic properties of the inner and outer membranes of rat liver mitochondria (1968) J. cell. Biol., 38, pp. 158-175
  • Cozza, Ceballos, del Vila, Lantos, Submitocondrial distribution of aldosterone biosynthesis (1986) Abstr. 174, 25. , J. steroid Biochem., Suppl
  • Sandor, Lanthier, The biosynthesis in vitro of radioactive corticosteroids from (4-14C) progesterone by adrenal slices of the domestic duck (Anas platyrhynchos) (1983) Biochimica et Biophysica Acta, 74, pp. 756-762
  • Sandor, Lamoureux, Lanthier, Adrenal cortical functions in reptiles. The in vitro biosynthesis of adrenal cortical steroids by adrenal slices of two common North American turtles, the slider turtle (Psuedemys scripta elegans) and the painted turtle (Chrysemys picta picta) (1964) Steroids, 4, pp. 213-228
  • Ulick, Kusch, A new C-18 oxygenated corticosteroid from bullfrog adrenals (1960) Journal of the American Chemical Society, 82, pp. 6421-6422
  • Damasco, Ceñal, Diaz, Lantos, Acute effects of three natural corticosteroids on the acid-base and electrolyte composition of urine in adrenalectomized rats (1979) Acta physiol. lat., 29, pp. 305-314
  • Sartorius, Calhoon, Pitts, Studies on the relationship of the adrenal cortex and renal ammonium excretion in the rat (1953) Endocr., 52, pp. 256-265
  • Peters, Díe adrenale Säure und Ammonium Ionen Ausscheidung normaler und adrenalektomierter Ratten und ihre Beeinflussung durch Nebennierenrindenhormone (1959) Naunyn Schmiedeberg's Arch. exp. Path. Pharmak., 235, pp. 196-204
  • Barter, Delea, Kawasaki, Gill, The adrenal cortex and the kidney (1974) Kidney International, 6, pp. 272-280
  • Welbourne, Phenix, Thornley Brown, Welborne, Triamcinolone activation of renal ammonia production (1976) Proc. Soc. exp. Biol. Med., pp. 539-542
  • Lanthier, Sandor, The effects of 18-OH-B on the salt secreting gland of the duck (Anas platyrhyncos) (1973) Can. J. Physiol. Pharmac., 51, pp. 776-778
  • Damasco, Ceñal, Vallverdú, Otero de Bedners, Lantos, Effects of 18-hydroxycorticosterone and of aldosterone on acid-base parameter in the arterial blood of adrenalectomized rats (1983) Acta. Physiol. lat., 33, pp. 283-291
  • Marver, Aldosterone action in target epithelia (1980) Vitam. Horm., 38, pp. 55-116
  • Damasco, Malnic, Effect of corticosteroids on proximal tubular acidification in the rat (1987) Mineral Electrolyte Metab., 13, pp. 26-32
  • Amorena, Fernandez, Malnic, Factors affecting proximal tubular acidification of non-bicarbonate buffer in the rat (1984) J. Physiol. (Lond.), 352, pp. 31-48
  • Kinne-Saffran, Kinne, ATP dependent proton transport in the renal tubule: studies on isolated vesicles (1982) Biochemistry of Kidney Function, pp. 403-409. , F. Morel, INSERM Symposium No. 21, Elsevier Biomedical Press, Amsterdam
  • Lichtwald, Przybylsky, “Dimers” of aldosterone (1985) Angew. Chem. Int. Ed. Engl., 24, pp. 130-131
  • Ulick, Marver, Adam, Funder, The mineralocorticoid antagonist activity of an 11 18-oxidopregnane (1979) Endocrinology, 104, pp. 1352-1356
  • Cozza, Lantos, Burton, A highly lipophilic form of aldosterone isolation and characterization of an aldosterone dimer (1985) J. steroid Biochem., 23, pp. 511-516
  • Kinsella, Cujdik, Sacktor, Na-H exchange activity in renal brush border membrane vesicles in response to metabolic acidosis: the role of glucocorticoids (1984) Proc. natn. Acad. Sci. U.S.A., 81, pp. 630-634
  • Dubrovsky, Nair, Byers, Levine, Renal net acid excretion in adrenalectomized rats (1981) Kidney International, 19, pp. 516-528

Citas:

---------- APA ----------
Lantos, C.P., Damasco, M.C., Aragonés, A., Ceballos, N.R., Burton, G. & Cozza, E.N. (1987) . Versatile steroid molecules at the end of the aldosterone pathway. Journal of Steroid Biochemistry, 27(4-6), 791-800.
http://dx.doi.org/10.1016/0022-4731(87)90151-8
---------- CHICAGO ----------
Lantos, C.P., Damasco, M.C., Aragonés, A., Ceballos, N.R., Burton, G., Cozza, E.N. "Versatile steroid molecules at the end of the aldosterone pathway" . Journal of Steroid Biochemistry 27, no. 4-6 (1987) : 791-800.
http://dx.doi.org/10.1016/0022-4731(87)90151-8
---------- MLA ----------
Lantos, C.P., Damasco, M.C., Aragonés, A., Ceballos, N.R., Burton, G., Cozza, E.N. "Versatile steroid molecules at the end of the aldosterone pathway" . Journal of Steroid Biochemistry, vol. 27, no. 4-6, 1987, pp. 791-800.
http://dx.doi.org/10.1016/0022-4731(87)90151-8
---------- VANCOUVER ----------
Lantos, C.P., Damasco, M.C., Aragonés, A., Ceballos, N.R., Burton, G., Cozza, E.N. Versatile steroid molecules at the end of the aldosterone pathway. J. Steroid Biochem. 1987;27(4-6):791-800.
http://dx.doi.org/10.1016/0022-4731(87)90151-8