Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Glucocorticoids (GC) have several known effects on the function of the nervous system, and GC receptors have been identified in regions responding to hormonal action. In the spinal cord, GC receptors have been characterized in vitro, which share several biochemical properties in common with receptors in better studied areas such as the hippocampus. Moreover, enzymes which are induced by GC in the hippocampus, such as glycerolphosphate dehydrogenase and ornithine decarboxylase, are also under specific GC control in the spinal cord. Yet GC receptors in the latter tissue divert from those in hippocampus during some in vivo as well as in vitro studies. In vivo, uptake of [3H]corticosterone by purified cell nuclei was 5-8-fold higher in the hippocampus as compared to the cord. In vitro, a higher percentage of GC receptors previously transformed by heating, showed affinity towards DNA-cellulose in the spinal cord than in the hippocampus. The enzyme RNAse A effectively increased receptor binding to DNA-cellulose in hippocampus, whereas the cord was insensitive to its action. These results suggest that there is a "receptor dysfunction" in the spinal cord, the significance of which is poorly understood in terms of the accepted model of steroid hormone action. © 1987.

Registro:

Documento: Artículo
Título:Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system
Autor:De Nicola, A.F.; Ortí, E.; Moses, D.F.; Magariños, A.M.; Coirini, H.
Filiación:Laboratorio de Esteroides, Instituto de Biologiá y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:corticosterone; dexamethasone; glucocorticoid receptor; glycerol 3 phosphate dehydrogenase; ornithine decarboxylase; radioisotope; rna; animal cell; animal experiment; central nervous system; hippocampus; methodology; nonhuman; rat; spinal cord; Aldosterone; Androstanols; Animal; Biological Transport; Cell Nucleus; Comparative Study; Corticosterone; Cytosol; Dexamethasone; DNA-Binding Proteins; Enzyme Induction; Hippocampus; Rats; Receptors, Glucocorticoid; Spinal Cord; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.
Año:1987
Volumen:27
Número:1-3
Página de inicio:599
Página de fin:607
DOI: http://dx.doi.org/10.1016/0022-4731(87)90359-1
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:corticosterone, 50-22-6; dexamethasone, 50-02-2; glycerol 3 phosphate dehydrogenase, 9001-49-4; ornithine decarboxylase, 9024-60-6; RNA, 63231-63-0; 11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one, 74915-64-3; Aldosterone, 52-39-1; Androstanols; Corticosterone, 50-22-6; Dexamethasone, 50-02-2; DNA-Binding Proteins; Receptors, Glucocorticoid
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v27_n1-3_p599_DeNicola

Referencias:

  • McEwen, Biegon, Davis, Krey, Luine, McGinnis, Paden, Rainbow, Steroid hormones: humoral signals which alter brain cell properties and functions (1982) Rec. Progr. Horm. Res., 38, pp. 41-92
  • Stumpf, Sar, Glucocorticosteroid and mineralocorticosteroid hormone target sites in the brain: autoradiographic studies with corticosterone, aldosterone and dexamethasone (1979) Interactions within the Brain-Pituitary-Adrenocortical System, pp. 137-147. , M.T. Jones, B. Gillham, M.F. Dallman, S. Chattopahyay, Academic Press, New York
  • Warembourgh, Steroid receptors in the brain: topography and some functional implications (1985) Neurochem. Int., 7, pp. 941-952
  • Coirini, Magariños, De Nicola, Rainbow, McEwen, Further studies of brain aldosterone binding sites employing new mineralo-corticoid and glucocorticoid receptor markers in vitro (1985) Brain Res., 361, pp. 212-216
  • Coirini, Marusic, De Nicola, Rainbow, McEwen, Identification of mineralocorticoid binding sites in rat brain by competition studies and density gradient centrifugation (1983) Neuroendocrinology, 37, pp. 354-360
  • Birmingham, Sar, Stumpf, Localization of aldosterone and corticosterone in the central nervous system, assessed by quantitative autoradiography (1984) Neurochem. Res., 9, pp. 333-350
  • Wrange, Yu, Mineralocorticoid receptor in rat kidney and hippocampus: characterization and quantitation by isoelectric focusing (1983) Endocrinology, 113, pp. 243-250
  • Luttge, Emadian, Densmore, Slatick, Efficacy of five methods for the bound-free separation of gluco- and mineralocorticoids form Type I, II and III receptors found in Hepes- and Tris-buffered mouse brain cytosol (1984) Steroids, 43, pp. 429-444
  • Marver, Aldosterone action in target epithelia (1980) Vitamins Horm., 38, pp. 57-117
  • Veldhuis, Van Kippen, Van Ittersum, De Kloett, Specificity of the adrenal steroid receptor system in rat hippocampus (1982) Endocrinology, 110, pp. 2044-2051
  • Fuxe, Wikstrom, Okret, Agnati, Harfstrand, Yu, Granholm, Gustafsson, Mapping of glucocorticoid receptor immunoreactive neurons in the rat tel- and diencephalon using a monoclonal antibody against rat liver glucocorticoid receptor (1985) Endocrinology, 117, pp. 1803-1812
  • Reul, De Kloet, Two receptor Systems for corticosterone in rat brain: microdistribution and differential occupation (1985) Endocrinology, 117, pp. 2502-2511
  • De Fiore, Turner, [3H]Corticosterone binding in the caudate-putamen (1983) Brain Res., 278, pp. 93-101
  • Meaney, Aitken, [3H]Dexamethasone binding in rat frontal cortex (1985) Brain Res., 328, pp. 176-182
  • McEwen, Lambdin, Rainbow, De Nicola, Aldosterone effects on salt appetite in adrenalectomized rats (1986) Newoendocrinology, 43, pp. 38-43
  • Meyer, Leveille, de Vellis, Gerlach, McEwen, Evidence for glucocorticoid target cells in the rat optic nerve. Hormone binding and glycerolphosphate dehydrogenase induction (1982) J. Neurochem., 39, pp. 423-434
  • Towle, Sze, [3H]Corticosterone binding in rat superior cervical ganglion (1982) Brain Res., 253, pp. 221-229
  • Duncan, Stumpf, A combined autoradiographic and immunocitochemical study of [3H]corticosterone target neurons and catecholamine neurons in rat and mouse lower brain stem (1985) Neuroendocrinology, 40, pp. 262-271
  • Clark, Maclusky, Naftolin, Glucocorticoid receptors in the spinal cord (1981) Brain Res., 217, pp. 412-415
  • Duncan, Stumpf, Target neurons for [3H]corticosterone in rat spinal cord (1984) Brain Res., 307, pp. 321-326
  • Ortí, Coirini, De Nicola, Properties and distribution of glucocorticoid-binding sites in cytosol of the spinal cord (1985) Neuroendocrinology, 40, pp. 225-231
  • Ortí, Tornello, De Nicola, Dynamic aspects of glucocorticoid receptors in the spinal cord of the rat (1985) J. Neurochem., 45, pp. 1699-1707
  • Ortí, Magarinos, De Nicola, Evidence of high affinity, stereoselective binding sites for [3H]aldosterone in the spinal cord (1986) Neuroendocrinology, 43, pp. 404-409
  • Hall, Glucocorticoid effects on central nervous excitability and synaptic transmission (1982) Int. Rev. Neurobiol., 23, pp. 165-195
  • Hall, Braughler, Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue (1981) Exp. Neurol., 73, pp. 321-324
  • Hall, McGinley, Effects of a single intravenous glucocorticoid dose on biogenic amine levels in cat lumbar spinal cord (1982) J. Neurochem., 39, pp. 1787-1790
  • Riker, Baker, Sastre, Electrophysiological and clinical aspects of glucocorticoids on certain neural systems (1982) Adrenal Actions on Brain, pp. 69-105. , D. Ganten, D. Pfaff, Springer-Verlag, Berlin
  • Stastny, Lisy, Sedlacek, Hajkova, The effect of cortisol on gamma-glutamyl transpeptidase activity in the glycogen body and lumbosacral segments of developing chick spinal cord (1985) Int. J. devl. Neurosci., 3, pp. 19-22
  • Beaumont, Fanestil, Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone (1983) Endocrinology, 113, pp. 2043-2051
  • Krozowski, Funder, Mineralocorticoid receptors in rat anterior pituitary: toward a redefinition of “mineralocorticoid hormone” (1981) Endocrinology, 109, pp. 1221-1224
  • Kornell, Kanamarlapudi, Travers, Taff, Tael, Chen, Baum, Raynor, Studies on high affinity binding of mineralo- and glucocorticoids in rabbit aorta cytosols (1982) J. steroid Biochem., 16, pp. 245-264
  • Palkovits, Isolated removal of hypothalamic or other brain nuclei of the rat (1973) Brain Res., 59, pp. 449-450
  • Munck, Wira, Young, Mosher, Hallahan, Bell, Glucocorticoid-receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells (1972) J. steroid Biochem., 3, pp. 567-578
  • Schmidt, Litwack, Activation of the glucocorticoid-receptor complex (1982) Physiol. Rev., 62, pp. 1131-1192
  • Sakahue, Thompson, Characterization of two forms of glucocorticoid hormone-receptor complex separated by DEAE cellulose column chromatography (1977) Biochem. biophys. Res. Commun., 77, pp. 533-541
  • Beato, Kalimi, Konstan, Feigelson, Interaction of glucocorticoids with rat liver nuclei. II. Studies on the nature of the cytosol transfer factor and the nuclear acceptor site (1973) Biochemistry, 12, pp. 3372-3379
  • Simons, Martínez, Garcea, Baxter, Tomkins, Interactions of glucocorticoid receptor-steroid complexes with acceptor sites (1976) J. biol. Chem., 251, pp. 334-343
  • Moses D. F., Ortí E., De Nicola A. F.: A comparison of the glucocorticoid receptor system in the spinal cord and hippocampus. Brain Res. (in press); McEwen, Glucocorticoid and hippocampus: receptors in search of a function (1982) Adrenal Action on Brain, pp. 1-22. , D. Gauten, D. Pfaff, Springer-Verlag, Berlin
  • Dahmer, Mousley, Pratt, Effects of molybdate and endogenous inhibitors on steroid-receptor inactivation, transformation and translocation (1984) Ann. Rev. Physiol., 46, pp. 67-81
  • Economidis, Rousseau, Association of the glucocorticoid hormone receptor with ribonucleic acid (1985) FEBS, 181, pp. 47-82
  • Feldman, Kallos, Hollander, RNA inhibits estrogen receptor binding to DNA (1981) J. biol. Chem., 256, pp. 1145-1148
  • Hutches, Markland, Hawkins, RNA induced reversal of glucocorticoid receptor activation (1982) Biochem. biophys. Res. Commun., 195, pp. 20-27
  • Chong, Lippman, Effects of RNA and ribonuclease on the binding of estrogen and glucocorticoid receptors from MCF-7 cells to DNA-cellulose (1982) J. biol. Chem., 257, pp. 2996-3002
  • Rossini, RNAse effects on sedimentation and DNA binding properties of dexamethasone-receptor complexes from HeLa-cell cytosol (1985) J. steroid Biochem., 22, pp. 47-56
  • Tymoczko, Phillips, The effects of ribonuclease on rat liver dexamethasone receptor: increased affinity for deoxyribonucleic acid and alternated sedimentation profile (1983) Endocrinology, 112, pp. 142-149
  • Kovacic-Milivojevic, La Pointe, Reker, Vedeckis, Ribonucleic acid is a component of the oligomeric, transformed mouse AtT-20 cell glucocorticoid receptor (1985) Biochemistry, 24, pp. 7357-7366
  • Ortí E., Moses D. F., Grillo C. and De Nicola A. F.: Glucocorticoid regulation of glycerolphosphate dehydrogenase and ornithine decarboxylase activities in the spinal cord of the rat. J. Neurochem. (in press); De Vellis, Inglish, Hormonal control of gylcerolphosphate dehydrogenase in the rat brain (1968) J. Neurochem., 15, pp. 1061-1070
  • Leveille, McGinnis, Maxwell, De, Immunochemical localization of glycerol-3-phosphate dehydrogenase in rat oligodendrocytes (1980) Brain Res., 196, pp. 287-305
  • Cousin, Lando, Moguilewsky, Ornithine decarboxylase induction by glucocorticoids in brain and liver of adrenalectomized rats (1982) J. Neurochem., 38, pp. 1296-1304
  • McGinnis, De Vellis, Glucocorticoid regulation in rat brain cell cultures: hydrocortisone increases the rate of synthesis of glycerol-phosphate dehydrogenase in CG glioma cells (1978) J. biol. Chem., 253, pp. 8483-8492
  • Russell, Snyder, Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo and various tumors (1968) Proc. natn. Acad. Sci. U.S.A., 60, pp. 1420-1427
  • Kumar, Weingarten, Callahan, Sachar, De Vellis, Regulation of m-RNAs for three enzymes in the glial cell model CG cell line (1984) J. Neurochem., 43, pp. 1455-1463
  • Tomkins, Martin, Hormones and gene expression (1970) Ann. Rev. Genet., 4, pp. 91-106
  • Endo, Induction of ornithine decarboxylase in mouse tissue following the injection of mitogenic substances. Enhancement by actynomycin D (1984) Biochem. Pharmac., 33, pp. 2123-2127
  • Sheridan, Androgen receptors in the brain: What are we measuring? (1983) Endocr. Rev., 4, pp. 171-178

Citas:

---------- APA ----------
De Nicola, A.F., Ortí, E., Moses, D.F., Magariños, A.M. & Coirini, H. (1987) . Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system. Journal of Steroid Biochemistry, 27(1-3), 599-607.
http://dx.doi.org/10.1016/0022-4731(87)90359-1
---------- CHICAGO ----------
De Nicola, A.F., Ortí, E., Moses, D.F., Magariños, A.M., Coirini, H. "Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system" . Journal of Steroid Biochemistry 27, no. 1-3 (1987) : 599-607.
http://dx.doi.org/10.1016/0022-4731(87)90359-1
---------- MLA ----------
De Nicola, A.F., Ortí, E., Moses, D.F., Magariños, A.M., Coirini, H. "Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system" . Journal of Steroid Biochemistry, vol. 27, no. 1-3, 1987, pp. 599-607.
http://dx.doi.org/10.1016/0022-4731(87)90359-1
---------- VANCOUVER ----------
De Nicola, A.F., Ortí, E., Moses, D.F., Magariños, A.M., Coirini, H. Functions and dysfunctions of receptors for adrenal corticoids in the central nervous system. J. Steroid Biochem. 1987;27(1-3):599-607.
http://dx.doi.org/10.1016/0022-4731(87)90359-1