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Abstract:

3αOH-5α-Pregnan-20-one (allo-THP), a steroid with strong anaesthetic properties, was found to be secreted by the adrenal gland of the rat in quantities similar to those secreted by the rat ovary. From the hypnotic potencies established for this and other endogenous steroids there can be little doubt that the total amount of steroids with anaesthetic properties produced in a female rat are sufficient to exert a depressant action on certain cells of the brain. In rats with intact adrenal glands a positive correlation existed between the adrenal secretion of allo-THP and pregnenolone or progesterone, whereas that between allo-THP and DOC was negative. This could be the result of a competition between the enzymes responsible for the oxidation and reduction of progesterone, the common precursor of allo-THP and DOC. The possibility that allo-THP could have hypotensive actions was suggested. © 1985.

Registro:

Documento: Artículo
Título:In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat
Autor:Holzbauer, M.; Birmingham, M.K.; de Nicola, A.F.; Oliver, J.T.
Filiación:A.F.R.C. Institute of Animal Physiology, Babraham, Cambridge CB2 4AT, U.K., United Kingdom
Department of Psychiatry, McGill University, Montreal, H3A 1A1 Que., Canada
Instituto de Biologia y Medicina Experimental, Buenos Aires, 1428, Argentina
Boehringer-Ingelheim U.S.A., Ridgefield, CT, United States
Palabras clave:3alpha hydroxy 5alpha pregnan 20 one; pregnenolone; progesterone; adrenal gland; animal experiment; drug analysis; drug blood level; drug determination; drug metabolism; endocrine system; nonhuman; priority journal; rat; steroid anesthesia; Adrenal Glands; Animal; Comparative Study; Desoxycorticosterone; Female; Kinetics; Pregnanes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains
Año:1985
Volumen:22
Número:1
Página de inicio:97
Página de fin:102
DOI: http://dx.doi.org/10.1016/0022-4731(85)90147-5
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:3alpha hydroxy 5alpha pregnan 20 one, 516-54-1; pregnenolone, 145-13-1; progesterone, 57-83-0; Desoxycorticosterone, 64-85-7; Pregnanes; Pregnanolone, 128-20-1; Pregnenolone, 145-13-1; Progesterone, 57-83-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v22_n1_p97_Holzbauer

Referencias:

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Citas:

---------- APA ----------
Holzbauer, M., Birmingham, M.K., de Nicola, A.F. & Oliver, J.T. (1985) . In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat. Journal of Steroid Biochemistry, 22(1), 97-102.
http://dx.doi.org/10.1016/0022-4731(85)90147-5
---------- CHICAGO ----------
Holzbauer, M., Birmingham, M.K., de Nicola, A.F., Oliver, J.T. "In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat" . Journal of Steroid Biochemistry 22, no. 1 (1985) : 97-102.
http://dx.doi.org/10.1016/0022-4731(85)90147-5
---------- MLA ----------
Holzbauer, M., Birmingham, M.K., de Nicola, A.F., Oliver, J.T. "In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat" . Journal of Steroid Biochemistry, vol. 22, no. 1, 1985, pp. 97-102.
http://dx.doi.org/10.1016/0022-4731(85)90147-5
---------- VANCOUVER ----------
Holzbauer, M., Birmingham, M.K., de Nicola, A.F., Oliver, J.T. In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat. J. Steroid Biochem. 1985;22(1):97-102.
http://dx.doi.org/10.1016/0022-4731(85)90147-5