Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of the diabetic animal. The results presented herein are in good agreement with the finding of a reduction in the number of androgen binding sites and also with a diminished activity of the 5α-reductase in the hypophysis from diabetic animals. The present results indicate an alteration in the hypophyseal gonadotropin production as well as in the overall process of hypophyseal response in experimental diabetes. © 1984.

Registro:

Documento: Artículo
Título:Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
Autor:Calvo, J.C.; Lino, J.; Barañao, S.; Tesone, M.; Charreau, E.H.
Filiación:Instituto de Biologia y Medicina Experimental, Buenos Aires (1428) and Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Obligado 2490, Argentina
Palabras clave:gonadorelin; isophane insulin; luteinizing hormone; radioisotope; streptozocin; 5alpha androstane 3alpha,17beta diol c 14; androstanolone c 14; animal experiment; animal model; diabetes mellitus; drug efficacy; endocrine system; hypothalamus hypophysis gonad system; nonhuman; rat; testosterone c 14; testosterone h 3; Animal; Castration; Diabetes Mellitus, Experimental; Gonadorelin; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Organ Weight; Rats; Rats, Inbred Strains; Receptors, Androgen; Support, Non-U.S. Gov't; Testis; Testosterone; Testosterone 5-alpha-Reductase
Año:1984
Volumen:20
Número:3
Página de inicio:769
Página de fin:772
DOI: http://dx.doi.org/10.1016/0022-4731(84)90083-9
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:gonadorelin, 33515-09-2, 9034-40-6; isophane insulin, 9004-17-5; luteinizing hormone, 39341-83-8, 9002-67-9; streptozocin, 18883-66-4; Gonadorelin, 33515-09-2; Luteinizing Hormone, 9002-67-9; Receptors, Androgen; Testosterone 5-alpha-Reductase, EC 1.3.99.5; Testosterone, 57-85-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v20_n3_p769_Calvo

Referencias:

  • Barañao, Legnani, Chiauzzi, Bertini, Suescun, Calvo, Charreau, Calandra, Effects of prolactin on androgen metabolism in androgen target tissues of immature rats (1981) Endocrinology, 109, pp. 2188-2195
  • Barley, Ginsburg, Greenstein, MacLusky, Thomas, An androgen receptor in rat brain and pituitary (1975) Brain Res., 100, pp. 383-393
  • Catt, Tsuruhara, Mendelson, Ketelslegers, Dufau, Gonadotropin binding and activation of the interstitial cells of the testis (1974) Hormone Binding and Target Cell Activation in the Testis, 1, pp. 1-30. , M.L. Dufau, A.R. Means, Plenum Press, New York
  • Charreau, Calvo, Tesone, Biella de Souza Valle, Barañao, Insulin regulation of Leydig cell LH receptors (1978) J. biol. Chem., 253, pp. 2504-2506
  • Christensen, Clemens, Intrahypothalamic implants of testosterone of estradiol and reumption of masculine sexual behavior in long-term castrated male rats (1974) Endocrinology, 95, pp. 984-990
  • Coirini, Weisenberg, Tornello, De Nicola, Effect of experimental diabetes on estradiol binding by the anterior pituitary and hypothalamus in ovariectomized rats (1980) Experientia, 36, pp. 683-685
  • Davidson, Sawyer, Evidence for an hypothalamic focus of inhibition of gonadotropin by androgen in the male (1961) Proc. Soc. exp. Biol. Med., 107, pp. 4-7
  • Denef, Magnus, McEwen, Sex differences and hormonal control of testosterone metabolism in rat pituitary and brain (1973) J. Endocr., 59, pp. 605-621
  • Foglia, Rosner, Cattáneo de Peralta Ramos, Lema, Sexual disturbances in the male diabetic rat (1969) Horm. Metab. Res., 1, pp. 72-77
  • Howland, Zebrowsky, Serum and pituitary gonadotropin levels in alloxan-diabetic rats (1974) Horm. Metab. Res., 6, pp. 121-124
  • Rowland, Zebrowsky, Some effects of experimentally-induced diabetes on pituitary-testicular relationships in rats (1976) Horm. Metab. Res., 8, pp. 465-469
  • Jouan, Samperez, Thieulant, Testosterone “receptors” in purified nuclei of rat anterior hypophysis (1973) Journal of Steroid Biochemistry, 4, pp. 65-74
  • Kalra, Kalra, Modulation of hypothalamic luteinizing hormone-releasing hormone levels by intracranial and subcutaneous implants of gonadal steroids in castrated rats: effects of androgen and estrogen antagonists (1980) Endocrinology, 106, pp. 390-397
  • Katzenellenbogen, Johnson, Carlson, Studies on the uterine, cytoplasmic estrogen binding protein. Thermal stability and ligand dissociation rate. An assay of empty and filled sites by exchange (1973) Biochemistry, 12, pp. 4092-4099
  • King, Mainwaring, (1974) Steroid-Cell Interactions, , University Park Press, Baltimore
  • Kingsly, Bogdanove, Direct feedback of androgens: localized effects of intrapituitary implants of androgens on gonadotropic cells and hormone stores (1973) Endocrinology, 93, pp. 1398-1409
  • Li, (1964) Introduction to Experimental Statistics, , McGraw-Hill, New York
  • Loras, Genot, Monbon, Buecher, Reboud, Bertrand, Binding and metabolism of testosterone in the rat brain during sexual maturation—II. Testosterone metabolism (1974) J. steroid Biochem., 5, pp. 425-431
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Monbon, Loras, Reboud, Bertrand, Binding and metabolism of testosterone in the rat brain during sexual maturation—I. Macromolecular binding of androgens (1974) J. steroid Biochem., 5, pp. 417-423
  • Naess, Attramadal, Aakvaag, Androgen binding proteins in the anterior pituitary, hypothalamus, preoptic area and brain cortex of the rat (1975) Endocrinology, 96, pp. 1-9
  • Naftolin, Ryan, Davies, Reddy, Flores, Kuhn, White, Wolin, The formation of estrogens by central neuroendocrine tissues (1975) Recent Prog. Horm. Res., 31, pp. 295-319
  • Smith, Davidson, Testicular maintenance and its inhibition in pituitary-transplanted rats (1967) Endocrinology, 80, pp. 725-734
  • Swerdloff, Walsh, Odell, Control of LH and FSH secretion in the male: evidence that aromatization of androgens to estradiol is not required for inhibition of gonadotropin secretion (1972) Steroids, 20, pp. 13-22
  • Tesone, Martins de Oliveira-Filho, Biella de Souza Valle, Calvo, Barañao, Charreau, Androgen receptors in the diabetic rat (1980) Diabetologia, 18, pp. 385-390
  • Tornello, Fridman, Weisenberg, Coirini, De Nicola, Differences in corticosterone binding by regions of the central nervous system in normal and diabetic rats (1981) J. steroid Biochem., 14, pp. 77-81

Citas:

---------- APA ----------
Calvo, J.C., Lino, J., Barañao, S., Tesone, M. & Charreau, E.H. (1984) . Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat. Journal of Steroid Biochemistry, 20(3), 769-772.
http://dx.doi.org/10.1016/0022-4731(84)90083-9
---------- CHICAGO ----------
Calvo, J.C., Lino, J., Barañao, S., Tesone, M., Charreau, E.H. "Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat" . Journal of Steroid Biochemistry 20, no. 3 (1984) : 769-772.
http://dx.doi.org/10.1016/0022-4731(84)90083-9
---------- MLA ----------
Calvo, J.C., Lino, J., Barañao, S., Tesone, M., Charreau, E.H. "Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat" . Journal of Steroid Biochemistry, vol. 20, no. 3, 1984, pp. 769-772.
http://dx.doi.org/10.1016/0022-4731(84)90083-9
---------- VANCOUVER ----------
Calvo, J.C., Lino, J., Barañao, S., Tesone, M., Charreau, E.H. Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat. J. Steroid Biochem. 1984;20(3):769-772.
http://dx.doi.org/10.1016/0022-4731(84)90083-9