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Abstract:

Cytosol binding of [3H]-corticosterone was studied in the anterior pituitary, hypothalamus, hippocampus and cerebral cortex from control and streptozotocin-diabetic male rats after adrenalectomy (ADX). Significant reductions in [3H]-corticosterone binding were observed in hypothalamus and hippocampus from ADX diabetics as compared to ADX controls, whereas no differences were obtained with anterior pituitary or cerebral cortex. In contrast to the behaviour of brain tissues, serum binding of [3H]-corticosterone was similar in both groups of ADX animals. Scatchard analysis indicated that the reduction in binding in hippocampus and hypothalamus was mostly due to changes in receptor concentration. Other parameters of metabolic function of the tissues, like glycine incorporation into proteins or orotic acid into RNA were similar in brain areas from control and diabetic rats. These findings are consistent with our earlier demonstration of a reduction of corticoid binding in whole brain from diabetic rats. The possibility is discussed that, although diabetes itself may be implicated in this reduction, it may also result from the action of high corticoid levels circulating in diabetics (Horm. Metab. Res. 9 (1977) 469-473), upon their own brain receptors. © 1981.

Registro:

Documento: Artículo
Título:Differences in corticosterone binding by regions of the central nervous system in normal and diabetic rats
Autor:Tornello, S.; Fridman, O.; Weisenberg, L.; Coirini, H.; De Nicola, A.F.
Filiación:Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:corticosterone h 3; radioisotope; streptozocin; unclassified drug; animal experiment; article; brain; central nervous system; corticosterone binding; diabetes mellitus; endocrine system; hormone receptor interaction; preliminary communication; rat; Scatchard plot; Adrenalectomy; Animals; Betaine; Brain; Cerebral Cortex; Corticosterone; Diabetes Mellitus, Experimental; Hippocampus; Hypothalamus; Male; Orotic Acid; Pituitary Gland, Anterior; Rats; Receptors, Steroid; RNA; Animalia
Año:1981
Volumen:14
Número:1
Página de inicio:77
Página de fin:81
DOI: http://dx.doi.org/10.1016/0022-4731(81)90195-3
Título revista:Journal of Steroid Biochemistry
Título revista abreviado:J. Steroid Biochem.
ISSN:00224731
CODEN:JSTBB
CAS:streptozocin, 18883-66-4; Betaine, 107-43-7; Corticosterone, 50-22-6; Orotic Acid, 65-86-1; RNA, 63231-63-0; Receptors, Steroid; corticosterone receptor
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v14_n1_p77_Tornello

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Citas:

---------- APA ----------
Tornello, S., Fridman, O., Weisenberg, L., Coirini, H. & De Nicola, A.F. (1981) . Differences in corticosterone binding by regions of the central nervous system in normal and diabetic rats. Journal of Steroid Biochemistry, 14(1), 77-81.
http://dx.doi.org/10.1016/0022-4731(81)90195-3
---------- CHICAGO ----------
Tornello, S., Fridman, O., Weisenberg, L., Coirini, H., De Nicola, A.F. "Differences in corticosterone binding by regions of the central nervous system in normal and diabetic rats" . Journal of Steroid Biochemistry 14, no. 1 (1981) : 77-81.
http://dx.doi.org/10.1016/0022-4731(81)90195-3
---------- MLA ----------
Tornello, S., Fridman, O., Weisenberg, L., Coirini, H., De Nicola, A.F. "Differences in corticosterone binding by regions of the central nervous system in normal and diabetic rats" . Journal of Steroid Biochemistry, vol. 14, no. 1, 1981, pp. 77-81.
http://dx.doi.org/10.1016/0022-4731(81)90195-3
---------- VANCOUVER ----------
Tornello, S., Fridman, O., Weisenberg, L., Coirini, H., De Nicola, A.F. Differences in corticosterone binding by regions of the central nervous system in normal and diabetic rats. J. Steroid Biochem. 1981;14(1):77-81.
http://dx.doi.org/10.1016/0022-4731(81)90195-3