Artículo

Villarreal, M.F.; Drucaroff, L.J.; Goldschmidt, M.G.; de Achával, D.; Costanzo, E.Y.; Castro, M.N.; Ladrón-de-Guevara, M.S.; Busatto Filho, G.; Nemeroff, C.B.; Guinjoan, S.M. "Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia" (2014) Journal of Psychiatric Research. 56(1):120-129
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Abstract:

Measures of social competence are closely related to actual community functioning in patients with schizophrenia. However, the neurobiological mechanisms underlying competence in schizophrenia are not fully understood. We hypothesized that social deficits in schizophrenia are explained, at least in part, by abnormally lateralized patterns of brain activation in response to tasks engaging social cognition, as compared to healthy individuals. We predicted such patterns would be partly heritable, and therefore affected in patients' nonpsychotic siblings as well. We used a functional magnetic resonance image paradigm to characterize brain activation induced by theory of mind tasks, and two tests of social competence, the Test of Adaptive Behavior in Schizophrenia (TABS), and the Social Skills Performance Assessment (SSPA) in siblings discordant for schizophrenia and comparable healthy controls (n=14 per group). Healthy individuals showed the strongest correlation between social competence and activation of right hemisphere structures involved in social cognitive processing, whereas in patients, the correlation pattern was lateralized to left hemisphere areas. Unaffected siblings of patients exhibited a pattern intermediate between the other groups. These results support the hypothesis that schizophrenia may be characterized by an abnormal functioning of nondominant hemisphere structures involved in the processing of socially salient information. © 2014 Elsevier Ltd.

Registro:

Documento: Artículo
Título:Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia
Autor:Villarreal, M.F.; Drucaroff, L.J.; Goldschmidt, M.G.; de Achával, D.; Costanzo, E.Y.; Castro, M.N.; Ladrón-de-Guevara, M.S.; Busatto Filho, G.; Nemeroff, C.B.; Guinjoan, S.M.
Filiación:National Council of Scientific and Technological Research (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina
Department of Mental Health, FLENI Teaching Unit, School of Medicine, University of Buenos Aires, Montañeses 2325, 8th Floor, Buenos Aires C1428AQK, Argentina
Department of Neurophysiology, School of Psychology, University of Buenos Aires, Hipólito Yrigoyen 3242, Buenos Aires C1207ABQ, Argentina
Departament of Physics, School of Exact and Natural Sciences, University of Buenos Aires Ciudad Universitaria, Buenos Aires, Argentina
FLENI, Department of Neurology, Montañeses 2325, Buenos Aires C1428AQK, Argentina
FLENI, Department of Psychiatry, Montañeses 2325, Buenos Aires C1428AQK, Argentina
Nucleo de Apoio à Pesquisa em Neurociência Aplicada, Universidade de São Paulo (NAPNA-USP), Brazil
Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, 1120 Northwest 14 St., Suite 1455, Miami, FL 33136, United States
Palabras clave:FMRI; Hemispheric dominance; Lateralization; Schizophrenia; Siblings; Social skills; adaptive behavior; adult; article; case control study; comparative study; controlled study; female; functional magnetic resonance imaging; heritability; human; male; named inventories, questionnaires and rating scales; observational study; priority journal; randomized controlled trial; right hemisphere; schizophrenia; sibling; social cognition; social competence; Social Skills Performance Assessment; test of adaptive behavior in schizophrenia; brain; brain mapping; cognition; hemispheric dominance; neuropsychological test; nuclear magnetic resonance imaging; pathophysiology; physiology; psychology; schizophrenia; social adaptation; social behavior; theory of mind; Adult; Brain; Brain Mapping; Case-Control Studies; Cognition; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Schizophrenia; Schizophrenic Psychology; Siblings; Social Behavior; Social Skills; Theory of Mind
Año:2014
Volumen:56
Número:1
Página de inicio:120
Página de fin:129
DOI: http://dx.doi.org/10.1016/j.jpsychires.2014.05.011
Título revista:Journal of Psychiatric Research
Título revista abreviado:J. Psychiatr. Res.
ISSN:00223956
CODEN:JPYRA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223956_v56_n1_p120_Villarreal

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Citas:

---------- APA ----------
Villarreal, M.F., Drucaroff, L.J., Goldschmidt, M.G., de Achával, D., Costanzo, E.Y., Castro, M.N., Ladrón-de-Guevara, M.S.,..., Guinjoan, S.M. (2014) . Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia. Journal of Psychiatric Research, 56(1), 120-129.
http://dx.doi.org/10.1016/j.jpsychires.2014.05.011
---------- CHICAGO ----------
Villarreal, M.F., Drucaroff, L.J., Goldschmidt, M.G., de Achával, D., Costanzo, E.Y., Castro, M.N., et al. "Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia" . Journal of Psychiatric Research 56, no. 1 (2014) : 120-129.
http://dx.doi.org/10.1016/j.jpsychires.2014.05.011
---------- MLA ----------
Villarreal, M.F., Drucaroff, L.J., Goldschmidt, M.G., de Achával, D., Costanzo, E.Y., Castro, M.N., et al. "Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia" . Journal of Psychiatric Research, vol. 56, no. 1, 2014, pp. 120-129.
http://dx.doi.org/10.1016/j.jpsychires.2014.05.011
---------- VANCOUVER ----------
Villarreal, M.F., Drucaroff, L.J., Goldschmidt, M.G., de Achával, D., Costanzo, E.Y., Castro, M.N., et al. Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia. J. Psychiatr. Res. 2014;56(1):120-129.
http://dx.doi.org/10.1016/j.jpsychires.2014.05.011