Abulafia, C.; Fiorentini, L.; Loewenstein, D.A.; Curiel-Cid, R.; Sevlever, G.; Nemeroff, C.B.; Villarreal, M.F.; Vigo, D.E.; Guinjoan, S.M. "Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients" (2019) Journal of Psychiatric Research. 112:23-29
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Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions subserving executive functions in asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD), suggesting that premature episodic memory deficits could be associated to executive dysfunction in this model. We hypothesized that O-LOAD would exhibit reduced executive performance evidenced by increased errors and decreased strategy use on an episodic memory task. We assessed 32 asymptomatic middle-aged O-LOAD and 28 age-equivalent control subjects (CS) with several tests that measure executive functions and the Rey Auditory Verbal Learning Test (RAVLT) to measure memory performance. All tests were scored using both traditional and process scores (quantification of errors and strategies underlying overall performance). T-tests were used to compare performance between both groups and Spearman correlations were implemented to measure associations between variables. O-LOAD participants exhibited decreased executive performance compared to CS as it relates to initiation time (Tower of London), mental switching (Trail Making Test B), and interference effects (Stroop Word-Color condition). Traditional RAVLT measures showed a poorer performance by O-LOAD and RAVLT process scores revealed increased interference effects on this group. Positive correlations (r s ) were found between the executive measures and several RAVLT measures for O-LOAD but not for CS. In conclusion, O-LOAD participants exhibited early subtle cognitive changes in executive processing. Observed memory difficulties may be associated in part to executive deficits suggesting an interplay between memory and executive functions. Process score impairments were observed earlier than clinical decline on neuropsychological scores in this at-risk cohort and might be useful cognitive markers of preclinical LOAD. © 2019 Elsevier Ltd


Documento: Artículo
Título:Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients
Autor:Abulafia, C.; Fiorentini, L.; Loewenstein, D.A.; Curiel-Cid, R.; Sevlever, G.; Nemeroff, C.B.; Villarreal, M.F.; Vigo, D.E.; Guinjoan, S.M.
Filiación:Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta. FLENI, Buenos Aires, Argentina
National Council for Scientific and Technological Research (CONICET), Argentina
Institute for Biomedical Research (BIOMED), School of Medical Sciences, Universidad Católica Argentina, Buenos Aires, Argentina
Servicio de Psiquiatría. FLENI, Buenos Aires, Argentina
Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, United States
Departamento de Neuropatología y Biología Molecular. FLENI, Buenos Aires, Argentina
Departamento de Docencia e Investigación. FLENI, Buenos Aires, Argentina
Institute of Early Life Adversity Research, Dell Medical School, The University of Texas, Austin, United States
Department of Physics (FCEyN), University of Buenos Aires, Argentina
School of Psychology and Educational Sciences, Katholieke Universiteit Leuven, Belgium
Departamento de Psiquiatría y Salud Mental, Unidad docente FLENI, Universidad de Buenos Aires, Facultad de Medicina, Argentina
Palabras clave:Executive functions; Preclinical late-onset Alzheimer's disease; Process scores; RAVLT; Subtle cognitive changes; adult; Alzheimer disease; Article; Beck Depression Inventory; controlled study; cross-sectional study; depression; educational status; episodic memory; executive function; family history; female; human; intelligence; major clinical study; male; middle aged; Mini Mental State Examination; neuropsychological test; priority journal; progeny; Rey auditory verbal learning test; Stroop test; tower of London test; trail making test
Página de inicio:23
Página de fin:29
Título revista:Journal of Psychiatric Research
Título revista abreviado:J. Psychiatr. Res.


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---------- APA ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., Villarreal, M.F.,..., Guinjoan, S.M. (2019) . Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients. Journal of Psychiatric Research, 112, 23-29.
---------- CHICAGO ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., et al. "Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients" . Journal of Psychiatric Research 112 (2019) : 23-29.
---------- MLA ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., et al. "Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients" . Journal of Psychiatric Research, vol. 112, 2019, pp. 23-29.
---------- VANCOUVER ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., et al. Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients. J. Psychiatr. Res. 2019;112:23-29.