Abstract:
A chemical method for determining the amount of niacinamide in multicomponent preparations was developed. Neither niacin resulting from the degradation of niacinamide nor vitamin A, thiamine hydrochloride, riboflavin, ascorbic acid, ergocalciferol, or calcium panththenate interferes. The method is based on the reaction of niacinamide with 1‐chloro‐2,4‐dinitrobenzene, followed by the spectrophotometric measurement of the colored solution obtained after treatment with sodium hydroxide. The proposed method is at least as accurate as the methods currently in use. A structure is proposed for the colored product, and its route of formation is outlined. Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company
Registro:
Documento: |
Artículo
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Título: | Specific colorimetric determination of niacinamide in dosage forms |
Autor: | Nudelman, N.S.; Nudelman, O. |
Filiación: | Instituto Nacional de Farmacologia y Bromatologia and Facultad de Ciencias Exactas (Depto. Quimica Orgánica), Universidad de Buenos Aires, Argentina
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Palabras clave: | Colorimetry—analysis, niacinamide in multicomponent vitamin preparations; Niacinamide—colorimetric analysis, multicomponent vitamin preparations; Vitamins—colorimetric analysis of niacinamide in multicomponent preparations; nicotinamide; nicotinic acid; colorimetry; drug determination; drug formulation; methodology; spectrophotometry; theoretical study; Colorimetry; Niacinamide; Temperature; Time Factors |
Año: | 1976
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Volumen: | 65
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Número: | 1
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Página de inicio: | 65
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Página de fin: | 67
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DOI: |
http://dx.doi.org/10.1002/jps.2600650112 |
Título revista: | Journal of Pharmaceutical Sciences
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Título revista abreviado: | J. Pharm. Sci.
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ISSN: | 00223549
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CAS: | nicotinamide, 11032-50-1, 98-92-0; nicotinic acid, 54-86-4, 59-67-6; Niacinamide, 98-92-0
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223549_v65_n1_p65_Nudelman |
Referencias:
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Citas:
---------- APA ----------
Nudelman, N.S. & Nudelman, O.
(1976)
. Specific colorimetric determination of niacinamide in dosage forms. Journal of Pharmaceutical Sciences, 65(1), 65-67.
http://dx.doi.org/10.1002/jps.2600650112---------- CHICAGO ----------
Nudelman, N.S., Nudelman, O.
"Specific colorimetric determination of niacinamide in dosage forms"
. Journal of Pharmaceutical Sciences 65, no. 1
(1976) : 65-67.
http://dx.doi.org/10.1002/jps.2600650112---------- MLA ----------
Nudelman, N.S., Nudelman, O.
"Specific colorimetric determination of niacinamide in dosage forms"
. Journal of Pharmaceutical Sciences, vol. 65, no. 1, 1976, pp. 65-67.
http://dx.doi.org/10.1002/jps.2600650112---------- VANCOUVER ----------
Nudelman, N.S., Nudelman, O. Specific colorimetric determination of niacinamide in dosage forms. J. Pharm. Sci. 1976;65(1):65-67.
http://dx.doi.org/10.1002/jps.2600650112