Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

A chemical method for determining the amount of niacinamide in multicomponent preparations was developed. Neither niacin resulting from the degradation of niacinamide nor vitamin A, thiamine hydrochloride, riboflavin, ascorbic acid, ergocalciferol, or calcium panththenate interferes. The method is based on the reaction of niacinamide with 1‐chloro‐2,4‐dinitrobenzene, followed by the spectrophotometric measurement of the colored solution obtained after treatment with sodium hydroxide. The proposed method is at least as accurate as the methods currently in use. A structure is proposed for the colored product, and its route of formation is outlined. Copyright © 1976 Wiley‐Liss, Inc., A Wiley Company

Registro:

Documento: Artículo
Título:Specific colorimetric determination of niacinamide in dosage forms
Autor:Nudelman, N.S.; Nudelman, O.
Filiación:Instituto Nacional de Farmacologia y Bromatologia and Facultad de Ciencias Exactas (Depto. Quimica Orgánica), Universidad de Buenos Aires, Argentina
Palabras clave:Colorimetry—analysis, niacinamide in multicomponent vitamin preparations; Niacinamide—colorimetric analysis, multicomponent vitamin preparations; Vitamins—colorimetric analysis of niacinamide in multicomponent preparations; nicotinamide; nicotinic acid; colorimetry; drug determination; drug formulation; methodology; spectrophotometry; theoretical study; Colorimetry; Niacinamide; Temperature; Time Factors
Año:1976
Volumen:65
Número:1
Página de inicio:65
Página de fin:67
DOI: http://dx.doi.org/10.1002/jps.2600650112
Título revista:Journal of Pharmaceutical Sciences
Título revista abreviado:J. Pharm. Sci.
ISSN:00223549
CAS:nicotinamide, 11032-50-1, 98-92-0; nicotinic acid, 54-86-4, 59-67-6; Niacinamide, 98-92-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223549_v65_n1_p65_Nudelman

Referencias:

  • Jeffus, M.T., Kenner, C.T., (1969) J. Pharm. Sci., 58, p. 749
  • Brunink, H., Wessels, E.J., (1972) Analyst, 97, p. 258
  • Strohecker, R., Henning, H.M., (1965) Vitamin Assay Tested Methods, p. 189. , Verlag Chemie GmB. H., Weinheim, Bergstr., Germany
  • (1965) Official Methods of Analysis, p. 763. , 10th ed., Association of Official Agricultural Chemists, Washington, D. C
  • Barton‐Wright, S.C., The microbiological assay of nicotinic acid in cereals and other products (1944) Biochemical Journal, 38, p. 314
  • Johnson, B.C., (1945) J. Biol. Chem., 159, p. 227
  • Vogel, A., (1964) A Text‐book of Practical Organic Chemistry, p. 169. , 3rd ed., Longman, New York, N. Y
  • (1970) The National Formulary, p. 475. , 13th ed., Mack Publishing Co., Easton, Pa
  • Pollit, R.J., Saunders, B.C., J. Chem. Soc., 1965, p. 4615
  • Vompe, A.F., Turitsyna, N.F., (1957) Zh. Obsch. Khim., 27, p. 3282
  • Légradi, L., (1967) Acta Chim. Acad. Sci. Hung., 52, p. 7
  • Grigoreva, N.E., Pechka, A.A., (1958) Zh. Obsch. Khim., 28, p. 1677
  • Mosher, A., (1950) Heterocycl. Comp., 1, p. 425
  • Creyf, S., Roosens, L., (1957) Meded. Vlaam. Chem. Ver., 19, p. 1
  • (1957) Chem. Abstr., 51, p. 16303d. , through

Citas:

---------- APA ----------
Nudelman, N.S. & Nudelman, O. (1976) . Specific colorimetric determination of niacinamide in dosage forms. Journal of Pharmaceutical Sciences, 65(1), 65-67.
http://dx.doi.org/10.1002/jps.2600650112
---------- CHICAGO ----------
Nudelman, N.S., Nudelman, O. "Specific colorimetric determination of niacinamide in dosage forms" . Journal of Pharmaceutical Sciences 65, no. 1 (1976) : 65-67.
http://dx.doi.org/10.1002/jps.2600650112
---------- MLA ----------
Nudelman, N.S., Nudelman, O. "Specific colorimetric determination of niacinamide in dosage forms" . Journal of Pharmaceutical Sciences, vol. 65, no. 1, 1976, pp. 65-67.
http://dx.doi.org/10.1002/jps.2600650112
---------- VANCOUVER ----------
Nudelman, N.S., Nudelman, O. Specific colorimetric determination of niacinamide in dosage forms. J. Pharm. Sci. 1976;65(1):65-67.
http://dx.doi.org/10.1002/jps.2600650112