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Abstract:

Signal processing in neuritic trees is ruled by the concerted action of passive and active membrane properties that, together, determine the degree of electrical compartmentalization of these trees. We analyzed how active properties modulate spatial propagation of graded signals in a pair of nonspiking (NS) neurons of the leech. NS neurons present a very extensive neuritic tree that mediates the interaction with all the excitatory motoneurons in leech ganglia. NS cells express voltageactivated Ca 2+ conductances (VACCs) that, under certain experimental conditions, evoke low-threshold spikes. We studied the distribution of calcium transients in NS neurons loaded with fluorescent calcium probes in response to low-threshold spikes, electrical depolarizing pulses, and synaptic inputs. The three types of stimuli evoked calcium transients of similar characteristics in the four main branches of the neuron. The magnitude of the calcium transients evoked by electrical pulses was a graded function of the change in NS membrane potential and depended on the baseline potential level. The underlying VACCs were partially inactivated at rest and strongly inactivated at - 20 mV. Stimulation of mechanosensory pressure cells evoked calcium transients in NS neurons whose amplitude was a linear function of the amplitude of the postsynaptic response. The results evidenced that VACCs aid an efficient propagation of graded signals, turning the vast neuritic tree of NS cells into an electrically compact structure. © 2013 the American Physiological Society.

Registro:

Documento: Artículo
Título:Wide propagation of graded signals in nonspiking neurons
Autor:Yang, S.M.; Vilarchao, M.E.; Rela, L.; Szczupak, L.
Filiación:Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
Instituto de Fisiología, Biología Molecular y Neurociencias, UBA-Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Grupo de Neurociencia de Sistemas, Facultad de Medicina, UBA, Buenos Aires, Argentina
Palabras clave:Calcium transients; Low threshold spike; Signal propagation; fluorescent dye; magnesium; amplitude modulation; article; calcium conductance; calcium transport; controlled study; depolarization; evoked response; ganglion; leech; membrane potential; motoneuron; nerve cell; neurite; nonhuman; nonspiking neuron; priority journal; Action Potentials; Animals; Calcium; Calcium Channels; Ganglia, Invertebrate; Leeches; Mechanoreceptors; Mechanotransduction, Cellular; Motor Neurons; Synaptic Potentials
Año:2013
Volumen:109
Número:3
Página de inicio:711
Página de fin:720
DOI: http://dx.doi.org/10.1152/jn.00934.2012
Título revista:Journal of Neurophysiology
Título revista abreviado:J. Neurophysiol.
ISSN:00223077
CODEN:JONEA
CAS:magnesium, 7439-95-4; Calcium, SY7Q814VUP; Calcium Channels
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v109_n3_p711_Yang

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Citas:

---------- APA ----------
Yang, S.M., Vilarchao, M.E., Rela, L. & Szczupak, L. (2013) . Wide propagation of graded signals in nonspiking neurons. Journal of Neurophysiology, 109(3), 711-720.
http://dx.doi.org/10.1152/jn.00934.2012
---------- CHICAGO ----------
Yang, S.M., Vilarchao, M.E., Rela, L., Szczupak, L. "Wide propagation of graded signals in nonspiking neurons" . Journal of Neurophysiology 109, no. 3 (2013) : 711-720.
http://dx.doi.org/10.1152/jn.00934.2012
---------- MLA ----------
Yang, S.M., Vilarchao, M.E., Rela, L., Szczupak, L. "Wide propagation of graded signals in nonspiking neurons" . Journal of Neurophysiology, vol. 109, no. 3, 2013, pp. 711-720.
http://dx.doi.org/10.1152/jn.00934.2012
---------- VANCOUVER ----------
Yang, S.M., Vilarchao, M.E., Rela, L., Szczupak, L. Wide propagation of graded signals in nonspiking neurons. J. Neurophysiol. 2013;109(3):711-720.
http://dx.doi.org/10.1152/jn.00934.2012