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Abstract:

Premotor and motoneurons could play regulatory roles in motor control. We have investigated the role of a premotor nonspiking (NS) neuron of the leech nervous system in two locomotive patterns: swimming and crawling. The NS neuron is coupled through rectifying electrical junctions to all the excitatory motoneurons examined. In addition, activation of motoneurons evokes chemically mediated inhibitory responses in NS. During swimming and crawling, the NS membrane potential (Vm NS) oscillated phase locked to the motor output. Hyperpolarization or depolarization of NS had no effect on swimming, but hyperpolarization of NS slowed down the crawling activity and decreased the motoneuron firing frequency. Depolarization of NS increased the motoneuron activity, and, at stages where the crawling pattern was fading, depolarization of NS reinstated it. Future work should determine if NS is actually a member of the central pattern generator or a regulatory element. © 2012 the American Physiological Society.

Registro:

Documento: Artículo
Título:Effect of a nonspiking neuron on motor patterns of the leech
Autor:Rodriguez, M.J.; Alvarez, R.J.; Szczupak, L.
Filiación:Departamento de Fisiología, Biología Molecular y Celular, FCEN-UBA, IFIBYNE UBA-CONICET, Buenos Aires, Argentina
Palabras clave:Motoneurons; Premotor; inwardly rectifying potassium channel; animal cell; article; cell population; controlled study; depolarization; hyperpolarization; leech; locomotion; membrane potential; motoneuron; motor performance; nervous system; nonhuman; oscillation; priority journal; swimming; Action Potentials; Animals; Dopamine; Electric Stimulation; Electrophysiology; Leeches; Motor Neurons; Nervous System; Patch-Clamp Techniques; Swimming
Año:2012
Volumen:107
Número:7
Página de inicio:1917
Página de fin:1924
DOI: http://dx.doi.org/10.1152/jn.01070.2011
Título revista:Journal of Neurophysiology
Título revista abreviado:J. Neurophysiol.
ISSN:00223077
CODEN:JONEA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v107_n7_p1917_Rodriguez

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Citas:

---------- APA ----------
Rodriguez, M.J., Alvarez, R.J. & Szczupak, L. (2012) . Effect of a nonspiking neuron on motor patterns of the leech. Journal of Neurophysiology, 107(7), 1917-1924.
http://dx.doi.org/10.1152/jn.01070.2011
---------- CHICAGO ----------
Rodriguez, M.J., Alvarez, R.J., Szczupak, L. "Effect of a nonspiking neuron on motor patterns of the leech" . Journal of Neurophysiology 107, no. 7 (2012) : 1917-1924.
http://dx.doi.org/10.1152/jn.01070.2011
---------- MLA ----------
Rodriguez, M.J., Alvarez, R.J., Szczupak, L. "Effect of a nonspiking neuron on motor patterns of the leech" . Journal of Neurophysiology, vol. 107, no. 7, 2012, pp. 1917-1924.
http://dx.doi.org/10.1152/jn.01070.2011
---------- VANCOUVER ----------
Rodriguez, M.J., Alvarez, R.J., Szczupak, L. Effect of a nonspiking neuron on motor patterns of the leech. J. Neurophysiol. 2012;107(7):1917-1924.
http://dx.doi.org/10.1152/jn.01070.2011