Artículo

Starkstein, S.E.; Sabe, L.; Chemerinski, E.; Jason, L.; Leiguarda, R. "Two domains of anosognosia in Alzheimer's disease" (1996) Journal of Neurology Neurosurgery and Psychiatry. 61(5):485-490
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Abstract:

Objective-To examine the presence of different dimensions of unawareness in patients with probable Alzheimer's disease. Methods-A consecutive series of 170 patients with probable Alzheimer's disease were assessed with the anosognosia questionnaire-dementia (AQ-D) which includes items related to cognitive deficits and behavioural problems. Results-A factor analysis of the AQ-D produced two factors: a 'cognitive unawareness' factor, which loaded on items of memory, spatial and temporal orientation, calculation, abstract reasoning, and praxis, and a 'behavioural unawareness' factor which loaded on items of irritability, selfishness, inappropriate emotional display, and instinctive disinhibition. A stepwise forward regression analysis showed significant correlations between the cognitive unawareness factor and more severe cognitive deficits, delusions, and apathy, but less depression. On the other hand, the behavioural unawareness factor correlated significantly with higher mania and pathological laughing scores. Whereas the cognitive unawareness factor showed a significant correlation with cognitive tests assessing verbal comprehension and long term memory, and was significantly associated with a longer duration of illness, no significant correlations were found between the behavioural unawareness factor and the neuropsychological tasks. Conclusion-Unawareness of cognitive deficits and unawareness of behavioural problems may constitute independent phenomena in Alzheimer's disease. Whereas unawareness of cognitive deficits is related to the severity of intellectual impairment and the presence of delusional apathetic mood, unawareness of behavioural problems may be part of a disinhibition syndrome.

Registro:

Documento: Artículo
Título:Two domains of anosognosia in Alzheimer's disease
Autor:Starkstein, S.E.; Sabe, L.; Chemerinski, E.; Jason, L.; Leiguarda, R.
Filiación:Department of Behavioral Neurology and Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina
Raúl Carrea Institute of Neurological Research, Montañeses 2325, 1428 Buenos Aires, Argentina
Palabras clave:Anosognosia; Behaviour; Dementia; aged; Alzheimer disease; anosognosia; article; cognitive defect; factorial analysis; female; human; long term memory; major clinical study; male; priority journal; regression analysis; time perception
Año:1996
Volumen:61
Número:5
Página de inicio:485
Página de fin:490
DOI: http://dx.doi.org/10.1136/jnnp.61.5.485
Título revista:Journal of Neurology Neurosurgery and Psychiatry
Título revista abreviado:J. NEUROL. NEUROSURG. PSYCHIATRY
ISSN:00223050
CODEN:JNNPA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223050_v61_n5_p485_Starkstein

Referencias:

  • Migliorelli, R., Teson, A., Sabe, L., Anosognosia in Alzheimer's disease: A study of associated factors (1995) J Neuropsychiatry Clin Neurosci, 7, pp. 338-344
  • Reisberg, B., Gordon, B., McCarthy, M., Insight and denial accompanying progressive cognitive decline in normal aging and Alzheimer's disease (1985) Geriatric Psychiatry: Ethical and Legal Issues, pp. 19-39. , Stanley B, ed. Washington, DC: American Psychiatric Press
  • Feher, E.P., Mahurin, R.K., Inbody, S.B., Crook, T.H., Pirozzolo, F.J., Anosognosia in Alzheimer's disease (1991) Neuropsychiatry, Neuropsychology and Behavioral Neurology, 4, pp. 136-146
  • Sevush, S., Leve, N., Denial of memory deficit in Alzheimer's disease (1993) Am J Psychiatry, 150, pp. 748-751
  • Reed, B.R., Jagust, W.J., Coulter, L., Anosognosia in Alzheimer's disease: Relationships to depression, cognitive function, and cerebral perfusion (1993) J Clin Exp Neuropsychol, 15, pp. 231-244
  • Vasterling, J.F., Seltzer, B., Foss, J.F., Vanderbrook, V., Unawareness of deficit in Alzheimer's disease: Domain-specific differences and disease correlates (1995) Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 8, pp. 26-32
  • López, O.L., Becker, J.T., Somsak, D., Dew, M.A., DeKosky, S.T., Awareness of cognitive deficits in probable Alzheimer's disease (1993) Eur Neurol, 34, pp. 277-282
  • Michon, A., Deweer, B., Pillon, B., Agid, Y., Dubois, B., Relation of anosognosia to frontal lobe dysfunction in Alzheimer's disease (1994) J Neurol Neurosurg Psychiatry, 57, pp. 805-809
  • McKhann, G., Drachman, D., Folstein, M.F., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease (1984) Neurology, 34, pp. 939-944
  • Hachinski, V.C., Iliff, L.D., Zilhka, L., Cerebral blood flow in dementia (1975) Arch Neurol, 40, pp. 97-103
  • Spitzer, R.L., Williams, J.B.W., Gibbon, M., First, M.B., The structured clinical interview for DSM-III-R SCID. I: History, rationale, and description (1992) Arch Gen Psychiatry, 49, pp. 624-629
  • (1987) Diagnostic and Statistical Manual of Mental Disorders. 3rd Ed, Revised, , Washington, DC: APA
  • Hamilton, M.A., A rating scale for depression (1960) J Neurol Neurosurg Psychiatry, 23, pp. 56-62
  • Hamilton, M.A., The assessment of anxiety states by rating (1959) Br J Med Psychol, 32, pp. 50-55
  • Bech, P., Kastrup, M., Rafaelsen, O.J., Mini-compendium of rating scales for states of anxiety, depression, mania, schizophrenia, with corresponding DSM-III syndromes (1986) Acta Psychiatr Scand, 73 (236 SUPPL.), pp. 29-31
  • Robinson, R.G., Parikh, R.M., Lipsey, J.R., Starkstein, S.E., Price, T.R., Pathological laughing and crying following stroke: Validation of measurement scale and double blind treatment study (1993) Am J Psychiatry, 150, pp. 286-293
  • Starkstein, S.E., Mayberg, H.S., Preziosi, T.J., Andrezejewski, M.A., Leiguarda, R., Robinson, R.G., Reliability, validity, and clinical correlates of apathy in Parkinson's disease (1992) J Neuropsychiatry Clin Neurosci, 4, pp. 134-139
  • Starkstein, S.E., Migliorelli, R., Manes, F., The prevalence and clinical correlates of apathy and irritability in Alzheimer's disease (1995) Journal of European Neurology, 2, pp. 540-546
  • Migliorelli, R., Petracca, G., Teson, A., Sabe, L., Leiguarda, R., Starkstein, S.E., Neuropsychiatric and neuropsychological correlates of delusions in Alzheimer's disease (1995) Psychol Med, 25, pp. 505-513
  • Granger, C.V., Hamilton, B.B., Kayton, R., (1986) Guide for Use of the Uniform Data Set for Medical Rehabilitation. Uniform Data System for Medical Rehabilitation, , Buffalo
  • Folstein, M.F., Folstein, S.E., McHugh, P.R., Mini-mental state: A practical method for grading the cognitive state of patients for the clinician (1975) J Psychiatr Res, 12, pp. 189-198
  • Raven, J.C., Court, J.H., Raven, J., (1986) Manual for Raven's Progressive Matrices and Vocabulary Scales, , London: HK Lewis
  • Nelson, H.E., A modified card sorting test sensitive to frontal lobe defects (1976) Cortex, 12, pp. 313-324
  • Benton, A.L., Differential behavioral effects in frontal lobe disease (1968) Neuropsychology, 6, pp. 53-60
  • Wechsler, D., (1955) Wechsler Adult Intelligence Scale Manual, , New York: Psychological Corporation
  • Buschke, H., Fuld, P.A., Evaluating storage, retention, and retrieval in disordered memory and learning (1974) Neurology, 24, pp. 1019-1025
  • De Renzi, E., Faglioni, P., Development of a shortened version of the token test (1978) Cortex, 14, pp. 41-49
  • Dalla Barba, G., Parlato, V., Iavarone, A., Boller, F., Anosognosia, intrusions and 'frontal' functions in Alzheimer's disease and depression (1995) Neuropsychology, 33, pp. 247-259
  • Marin, R.S., Apathy: A neuropsychiatric syndrome (1991) J Neuropsychiatry Clin Neurosci, 3, pp. 243-254
  • Starkstein, S.E., Vazquez, S., Petracca, G., Teson, A., Migliorelli, R., Leiguarda, R., A SPECT study of delusions in Alzheimer's disease (1994) Neurology, 44, pp. 2055-2059
  • Johnson, S., Orrell, M., Insight: A social perspective (1995) Psychol Med, 25, pp. 515-520
  • David, A., Buchanan, A., Ried, A., Almeida, O., The assessment of insight in psychosis (1992) Br J Psychiatry, 161, pp. 599-602

Citas:

---------- APA ----------
Starkstein, S.E., Sabe, L., Chemerinski, E., Jason, L. & Leiguarda, R. (1996) . Two domains of anosognosia in Alzheimer's disease. Journal of Neurology Neurosurgery and Psychiatry, 61(5), 485-490.
http://dx.doi.org/10.1136/jnnp.61.5.485
---------- CHICAGO ----------
Starkstein, S.E., Sabe, L., Chemerinski, E., Jason, L., Leiguarda, R. "Two domains of anosognosia in Alzheimer's disease" . Journal of Neurology Neurosurgery and Psychiatry 61, no. 5 (1996) : 485-490.
http://dx.doi.org/10.1136/jnnp.61.5.485
---------- MLA ----------
Starkstein, S.E., Sabe, L., Chemerinski, E., Jason, L., Leiguarda, R. "Two domains of anosognosia in Alzheimer's disease" . Journal of Neurology Neurosurgery and Psychiatry, vol. 61, no. 5, 1996, pp. 485-490.
http://dx.doi.org/10.1136/jnnp.61.5.485
---------- VANCOUVER ----------
Starkstein, S.E., Sabe, L., Chemerinski, E., Jason, L., Leiguarda, R. Two domains of anosognosia in Alzheimer's disease. J. NEUROL. NEUROSURG. PSYCHIATRY. 1996;61(5):485-490.
http://dx.doi.org/10.1136/jnnp.61.5.485